A5001643442- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Prenatal Screening and Diagnostics
- Neonatal Respiratory Health Research
- Maternal and Perinatal Health Interventions
- Maternal and fetal healthcare
- Assisted Reproductive Technology and Twin Pregnancy
- Pregnancy and Medication Impact
- Reproductive System and Pregnancy
- Child Nutrition and Water Access
- Obesity, Physical Activity, Diet
- Global Maternal and Child Health
- Cardiovascular Issues in Pregnancy
- Neuroscience of respiration and sleep
- Obstructive Sleep Apnea Research
- Fetal and Pediatric Neurological Disorders
- Neonatal and fetal brain pathology
- COVID-19 Impact on Reproduction
- Infant Development and Preterm Care
- Maternal Mental Health During Pregnancy and Postpartum
- Preterm Birth and Chorioamnionitis
- Cytomegalovirus and herpesvirus research
- Blood Coagulation and Thrombosis Mechanisms
- Congenital Diaphragmatic Hernia Studies
The University of Melbourne
2016-2025
Mercy Hospital for Women
2016-2025
Holistic Management International
2024
Tygerberg Hospital
2022-2024
The University of Sydney
2018-2024
Stellenbosch University
2022-2024
Mercy Health
2021-2024
Peninsula Health
2024
Monash Health
2004-2024
Royal Children's Hospital
2010-2024
OBJECTIVE—We sought to determine the long-term risk of type 2 diabetes following a pregnancy complicated by gestational mellitus (GDM) and assess what maternal antepartum, postpartum, neonatal factors are predictive later development diabetes. RESEARCH DESIGN AND METHODS—This was retrospective cohort study using survival analysis on 5,470 GDM patients 783 control subjects who presented for postnatal follow-up at Mercy Hospital Women between 1971 2003. RESULTS—Risk developing increased with...
The preferred timing of umbilical-cord clamping in preterm infants is unclear.We randomly assigned fetuses from women who were expected to deliver before 30 weeks gestation either immediate the umbilical cord (≤10 seconds after delivery) or delayed (≥60 delivery). primary composite outcome was death major morbidity (defined as severe brain injury on postnatal ultrasonography, retinopathy prematurity, necrotizing enterocolitis, late-onset sepsis) by 36 postmenstrual age. Analyses performed an...
Abstract Copy number variations (CNVs) are implicated across many neurodevelopmental disorders (NDDs) and contribute to their shared genetic etiology. Multiple studies have attempted identify etiology among NDDs, but this is the first genome-wide CNV analysis autism spectrum disorder (ASD), attention deficit hyperactivity (ADHD), schizophrenia (SCZ), obsessive-compulsive (OCD) at once. Using microarray (Affymetrix CytoScan HD), we genotyped 2,691 subjects diagnosed with an NDD (204 SCZ,...
Human cytomegalovirus (HCMV) can establish both nonproductive (latent) and productive (lytic) infections. Many of the proteins expressed during these phases infection could be expected to targets immune response; however, much our understanding CD8(+)-T-cell response HCMV is mainly based on pp65 antigen. Very little known about T-cell control over other antigens different stages virus infection; this imbalance in undermines importance several aspects disease pathogenesis. In present study,...
Evidence for an association between general obesity and risk of stroke is weak. However, abdominal may be more closely related to risk. The body mass index (waist/hip ratio) with incidence was examined in 28,643 US male health professionals, aged 40–75 years 1986, who had no history cardiovascular disease or stroke. In 5 follow-up, there were 118 cases stroke, which 80 ischemic. Compared men the lowest quintile index, highest age-adjusted relative 1.29 (95% confidence interval 0.73–2.27)...
Abstract— Preeclampsia is a major pregnancy complication where excess placental release of soluble fms-like tyrosine kinase-1 (sFlt-1) and endoglin causes maternal endothelial multisystem organ injury. Clinical trials have commenced examining whether pravastatin can be used to treat preeclampsia. However, the preclinical evidence supporting as treatment limited animal models, with almost no studies in human tissues. Therefore, we examined reduced sFlt-1 secretion decreased dysfunction...
Rare copy number variants (CNVs) disrupting ASTN2 or both and TRIM32 have been reported at 9q33.1 by genome-wide studies in a few individuals with neurodevelopmental disorders (NDDs). The vertebrate-specific astrotactins, its paralog ASTN1, key roles glial-guided neuronal migration during brain development. To determine the prevalence of astrotactin mutations delineate their associated phenotypic spectrum, we screened ASTN2/TRIM32 ASTN1 (1q25.2) for exonic CNVs clinical microarray data from...
Abstract: We have developed a novel diagnostic technology to monitor the human cytomegalovirus (HCMV)‐specific CD8+ T‐cell responses that is based on detection of secreted interferon‐gamma (IFN‐γ) in whole blood (referred as QuantiFERON ® ‐CMV). Evaluation ‐CMV healthy individuals revealed this was at least sensitive and with some HCMV epitopes more than ELISPOT for detecting ex vivo IFN‐γ. Results from assays showed 97% (36/37 individuals) agreement anti‐HCMV serology test individuals....
Pregnant women have been identified as a group at risk of increased morbidity and mortality associated with the pandemic H1N1 influenza A 2009 (H1N1/09) outbreak.Six hospitals in state Victoria, Australia, contributed retrospective prospective demographic clinical data, reason for admission maternal fetal outcome data laboratory-confirmed H1N1/09 admitted to hospital from 20 May through 31 July 2009.Forty-three cases were reported during study period, including 8 intensive care unit...
Objective The objective of this study is to determine whether obstructive sleep apnea (OSA) associated with reduced fetal growth, and nocturnal oxygen desaturation precipitates acute heart rate changes. Study Design We performed a prospective observational study, screening 371 women in the second trimester for OSA symptoms. 41 subsequently underwent overnight studies diagnose OSA. Third growth was assessed using ultrasound. Fetal monitoring accompanied study. Cord blood taken at delivery,...
Abstract Background and objective Poorly controlled asthma during pregnancy is hazardous for both mother foetus. Better control may be achieved if patients are involved in regular self‐monitoring of symptoms self‐management according to a written action plan. Telehealth applications optimize management outcomes pregnant women have not yet been evaluated. This study evaluated the efficacy telehealth programme supported by handheld respiratory device improving pregnancy. Methods Pregnant with...
131 million women give birth annually. This population is particularly vulnerable to emerging infectious pathogens due alterations in immune, respiratory, and cardiovascular physiology that occur during pregnancy. Recent outbreaks of severe acute respiratory syndrome, Middle East influenza H1N1, Ebola virus disease, Zika disease exposed high rates maternal morbidity mortality, fetal loss, harm. Early data regarding pregnancy outcomes COVID-19 are reassuring: similar non-pregnant adults,...
To assess the effect of maternal sildenafil therapy on fetal growth in pregnancies with early-onset restriction.A randomised placebo-controlled trial.Thirteen maternal-fetal medicine units across New Zealand and Australia.Women singleton affected by restriction at 22+0 to 29+6 weeks.Women were oral administration 25 mg citrate or visually matching placebo three times daily until 32+0 weeks, birth death (whichever occurred first).The primary outcome was proportion an increase velocity....
Abstract Objective To evaluate whether extended release metformin could be used to prolong gestation in women being expectantly managed for preterm pre-eclampsia. Design Randomised, double blind, placebo controlled trial. Setting Referral hospital Cape Town, South Africa. Participants 180 with pre-eclampsia between 26+0 31+6 weeks’ undergoing expectant management: 90 were randomised and placebo. Intervention 3 g of oral or daily, divided doses, until delivery. Main outcome measure The...
BackgroundGenomic sequencing technology allows for identification of reproductive couples with an increased chance, as compared that in the general population, having a child autosomal recessive or X-linked genetic condition.MethodsWe investigated feasibility, acceptability, and outcomes nationwide, couple-based carrier screening program Australia part Mackenzie's Mission project. Health care providers offered to persons before pregnancy early pregnancy. The results obtained from testing at...