A5014214162- Influenza Virus Research Studies
- Respiratory viral infections research
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Pneumonia and Respiratory Infections
- Antibiotics Pharmacokinetics and Efficacy
- Streptococcal Infections and Treatments
- Infective Endocarditis Diagnosis and Management
- Sepsis Diagnosis and Treatment
- Emergency and Acute Care Studies
- Parasites and Host Interactions
- Nosocomial Infections in ICU
- Smoking Behavior and Cessation
- Cardiovascular Effects of Exercise
- Adolescent Sexual and Reproductive Health
- Parasitic infections in humans and animals
- Vaccine Coverage and Hesitancy
- Chemical Looping and Thermochemical Processes
- Surgical site infection prevention
- Muscle and Compartmental Disorders
- Inflammatory Myopathies and Dermatomyositis
- Vector-Borne Animal Diseases
- Viral Infections and Vectors
- HIV/AIDS Impact and Responses
- Infectious Aortic and Vascular Conditions
Northern Health
2022-2025
Alice Springs Hospital
2011-2021
Northern Hospital
2016-2021
Menzies School of Health Research
2015
Royal Adelaide Hospital
2015
Royal Darwin Hospital
2015
South Australia Pathology
2015
Imperial College London
2015
The Alfred Hospital
2012
Monash Medical Centre
2009-2010
Pregnant women have been identified as a group at risk of increased morbidity and mortality associated with the pandemic H1N1 influenza A 2009 (H1N1/09) outbreak.Six hospitals in state Victoria, Australia, contributed retrospective prospective demographic clinical data, reason for admission maternal fetal outcome data laboratory-confirmed H1N1/09 admitted to hospital from 20 May through 31 July 2009.Forty-three cases were reported during study period, including 8 intensive care unit...
Objective: To describe the case characteristics and outcomes of patients hospitalised with pandemic (H1N1) 2009 influenza infection during first 2 months epidemic. Design, participants setting: Prospective series 112 admitted to seven hospitals in Melbourne laboratory-confirmed between 1 May 17 July 2009. Main outcome measures: Details characteristics, risk factors for severe disease, treatment clinical course. Results: Of patients, most presented cough (88%) and/or fever (82%), but several...
We examined the effect of transition to electronic medical records on antimicrobial stewardship service (AMS) in our healthcare service, finding significant increases (P < 0.001) number and type prescribed restricted antimicrobials identified for review, patients seen, AMS intervention significance post transition.
Annual influenza vaccine is recommended for those at greatest risk of severe infection. Recent reports a negative impact serial vaccination on effectiveness (VE) raises concerns about the recommendation annual vaccines, particularly in persons risk. The Influenza Complications Alert Network (FluCAN) an Australian hospital-based sentinel surveillance program. In this observational study, cases were defined as subjects aged >9 years admitted with confirmed by polymerase chain reaction....
The Influenza Complications Alert Network (FluCAN) is a sentinel hospital-based surveillance programme operating in all states and territories Australia. We summarise the epidemiology of children hospitalised with laboratory-confirmed influenza 2014 reports on effectiveness inactivated trivalent vaccine (TIV) children. In this observational study, cases were defined as admitted acute respiratory illness (ARI) confirmed by PCR. Controls ARI testing negative for influenza. Vaccine (VE) was...
SUMMARY This study aimed to examine the epidemiology and treatment outcomes of community-onset purulent staphylococcal skin soft tissue infections (SSTI) in Central Australia. We performed a prospective observational patients hospitalised with SSTI ( n = 160). Indigenous accounted for 78% cases. Patients were predominantly young adults; however, there high rates co-morbid disease. Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) was dominant phenotype, accounting...
After heavy rains and flooding during early 2011 in the normally arid interior of Australia, melioidosis was diagnosed 6 persons over a 4-month period. Although precise global distribution causal bacterium Burkholderia pseudomallei remains to be determined, this organism can clearly survive harsh even desert environments outside wet tropics.
Superficial skin and soft tissue infections (SSTIs) are common among the Indigenous population of desert regions Central Australia. However, overall burden disease molecular epidemiology Staphylococcus aureus complicated SSTIs has yet to be described in this unique population.Alice Springs Hospital (ASH) admission data was interrogated establish incidence SSTIs. A prospective observational study conducted on a subset S. (carbuncles furuncles requiring surgical intervention) presenting during...
We report the first case of myositis and rhabdomyolysis after infection with novel influenza A (H1N1/09) virus. The demonstrates virus' capacity for causing significant disease. Myositis possibility should be considered in any individual presenting influenza-like symptoms which severe myalgia or muscle weakness is apparent. It likely that we will see clinical manifestations this virus coming respiratory season.
Infectious diseases remain the leading cause of death at Alice Springs Hospital (ASH) and Staphylococcus aureus bacteraemia (SAB) is second most common bloodstream infection. Non-multidrug-resistant, methicillin-resistant S. (nmMRSA) endemic to region.To determine whether differences exist between racial groups resistance phenotypes in clinical manifestations outcomes SAB ASH.A retrospective review medical pathology records for inpatients with 1 January 2003 31 December 2006.A total 125...
The Central Australian Indigenous population has a high incidence of Staphylococcus aureus bacteremia (SAB) but little is known about the local molecular epidemiology. Prospective observational study bacteremic and nasal colonizing S.aureus isolates between June 2006 to 2010. All underwent single nucleotide polymorphism (SNP) genotyping testing for presence Panton-Valentine Leucocidin (pvl) gene. Invasive (n = 97) were predominantly ST93 (26.6 %) pvl positive (54.3 %), which was associated...
There are no available pharmacokinetic data to guide piperacillin dosing in critically ill Australian Indigenous patients despite numerous reported physiological differences. This study aimed describe the population pharmacokinetics of with severe sepsis. A sepsis was conducted a remote hospital intensive care unit. Plasma samples were collected over two intervals and assayed by validated chromatography. Population modeling using Pmetrics. Nine recruited, two-compartment model adequately...
Vancomycin is a commonly used antibiotic due to the high burden of methicillin-resistant Staphylococcus aureus infections. This study aimed describe pharmacokinetics (PK) vancomycin in Australian Indigenous patients with severe sepsis, and advise an optimal dosing strategy. A population PK was conducted remote intensive care unit (ICU). Serial plasma samples were collected over one two intervals assayed by validated chromatography. Concentration–time data analysed using Pmetrics® software....
We retrospectively audited hospital occupational exposure events over a 10-year period, in human T-cell lymphotropic virus type 1 (HTLV-1)-endemic area of Central Australia, and report on 53 individuals exposed to HTLV-1 with no transmissions documented (95% confidence interval, 0%-1.5%). This has important implications for the management exposures including role postexposure prophylaxis.
Severe community-acquired pneumonia (SCAP) has high mortality and morbidity.To describe the epidemiology microbiology of SCAP in Central Australia.A retrospective epidemiological study describing characteristics, incidence rates (IR) microbiological aetiology Australia. Adult patients admitted to Alice Springs Hospital Intensive Care Unit (ICU) between 2011 2014 that fitted Infectious Diseases Society America American Thoracic definition were included. Medical records reviewed compared...
To determine the utility of exercise electrocardiography testing (EET) in evaluating suspected coronary artery disease a remote Australian setting where significant proportion patients are Indigenous Australians. Retrospective cohort study with grouping based on EET results. 268 who underwent at Alice Springs Hospital--a specialist teaching hospital Central Australia no resident cardiology service--in period 1 June 2009 to 31 May 2010. Diagnosis disease, angiography and/or admission acute...
Severe community-acquired pneumonia (SCAP) is highly prevalent in the Aboriginal population. Few severity scores are validated this population.To assess prediction accuracy of patients with SCAP and to identify risk factors for poor prognosis.Retrospective cohort study examining admitted intensive care unit confirmed between January 2011 December 2014. Severity were calculated SMARTCOP (systolic blood pressure, multi-lobar, albumin, respiratory rate, tachycardia, confusion, oxygenation...