A5040961140- Antimicrobial Resistance in Staphylococcus
- Complement system in diseases
- Atrial Fibrillation Management and Outcomes
- African history and culture studies
- Cardiac electrophysiology and arrhythmias
- Infective Endocarditis Diagnosis and Management
- Bacterial Identification and Susceptibility Testing
- Cardiac Arrhythmias and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Streptococcal Infections and Treatments
- Political Economy and Marxism
- Pelvic floor disorders treatments
- Respiratory viral infections research
- Astronomical Observations and Instrumentation
- Global Maritime and Colonial Histories
- Clostridium difficile and Clostridium perfringens research
- Blood Coagulation and Thrombosis Mechanisms
- Gut microbiota and health
- Pneumonia and Respiratory Infections
- Acute Ischemic Stroke Management
- Bacterial Infections and Vaccines
- Lipoproteins and Cardiovascular Health
- African history and culture analysis
- Antifungal resistance and susceptibility
- Economic Theory and Policy
Flinders Medical Centre
2015-2024
South Australia Pathology
2015-2024
Flinders University
2013-2024
University of Oklahoma Health Sciences Center
2014-2024
SA Health
2020-2024
Western Health
2024
San Francisco General Hospital
2024
Nuffield Health
2024
Bristol-Myers Squibb (United States)
2001-2024
National Health and Medical Research Council
2024
The etiology of ischemic stroke affects prognosis, outcome, and management. Trials therapies for patients with acute should include measurements responses as influenced by subtype stroke. A system categorization subtypes mainly based on has been developed the Trial Org 10172 in Acute Stroke Treatment (TOAST). classification was prepared using clinical features results ancillary diagnostic studies. "Possible" "probable" diagnoses can be made physician's certainty diagnosis. usefulness...
Preface 1. The historical transformation of labor: an overview 2. Long swings and stages capitalism 3. Initial proletarianization: 1820s to 1890s 4. the homogenization 1870s World War II 5. segmentation 1920s present 6. A recapitulation Notes Bibliography Index.
The durability of infection-induced SARS-CoV-2 immunity has major implications for reinfection and vaccine development. Here, we show a comprehensive profile antibody, B cell T dynamics over time in cohort patients who have recovered from mild-moderate COVID-19. Binding neutralising antibody responses, together with individual serum clonotypes, decay the first 4 months post-infection. A similar decline Spike-specific CD4+ circulating follicular helper frequencies occurs. By contrast,...
To assess the efficacy and safety of subcutaneous (SC) belimumab in patients with systemic lupus erythematosus (SLE).Patients moderate-to-severe SLE (score ≥8 on Safety Estrogens Lupus Erythematosus National Assessment [SELENA] version Disease Activity Index [SLEDAI]) were randomized 2:1 to receive weekly SC 200 mg or placebo by prefilled syringe addition standard therapy for 52 weeks. The primary end point was Responder (SRI4) at week 52. Secondary points reduction corticosteroid dosage...
Intravenous belimumab plus standard of care (SoC) is approved in the USA and Europe for treatment active, autoantibody-positive systemic lupus erythematosus (SLE).This phase III, multicentre, randomised, double-blind, placebo-controlled study (BEL113750; NCT01345253) was conducted 49 centres across China, Japan South Korea (May 2011-September 2015). Patients with SLE were randomised 2:1 to intravenous 10 mg/kg or placebo, SoC, every 4 weeks until Week 48. The primary endpoint Responder Index...
Host factors and complications have been associated with higher mortality in infective endocarditis (IE). We sought to develop validate a model of clinical characteristics predict 6-month IE.Using large multinational prospective registry definite IE (International Collaboration on Endocarditis [ICE]-Prospective Cohort Study [PCS], 2000-2006, n=4049), survival was developed by Cox proportional hazards modeling inverse probability weighting for surgery treatment internally validated the...
Previous meta-analyses of summary data from randomised controlled trials have shown that statin therapy increases the risk diabetes, but less is known about size or timing this effect, who at greatest risk. We aimed to address these gaps in knowledge through analysis individual participant large, long-term, randomised, double-blind therapy.
Abstract Factor H, a regulator of complement activation, contains 20 short consensus repeat (SCR) domains common among the family C3b/C4b-binding proteins. Chinese hamster ovary cells transfected with cDNA corresponding to N-terminal tryptic fragment factor H (containing SCR 1-5 and part 6) secreted protein cofactor activity for I-dependent cleavage C3b. A series deletion mutants, each lacking one first five SCR, were constructed, supernatants tested activity. Supernatants 1, 4, 5 mutants...
Abstract Complement factor H (fH) regulates activation of the alternative pathway C, reducing amount C3b deposited on sialic acid-rich surfaces. Heparin binding has been used as a model for examining acid-binding characteristics fH. We have previously shown that 20 short consensus repeat (SCR) modules fH, SCR 7 contains an important heparin site, but other SCRs also play role in binding. To localize sites, we prepared recombinant truncated and deletion mutants fH tested them by...
This paper seeks to explain trends in United States corporate profitability since World War II through an analysis of the rise and subsequent demise a postwar social structure accumulation (SSA). Building from formal model determinants profitability, we provide econometric support for hypothesis that variations can be explained large extent by quantitative indicators capitalist power SSA.
Abstract Surface polyanions such as sialic acid and heparin are thought to enhance the binding of complement factor H (fH) C3b deposited on particles cell surfaces, thereby reducing activation. fH contains 20 short consensus repeat (SCR) domains, it has been proposed that SCR 13 a site. We used recombinant proteins determine site fH. Full-length (H20) truncated deletion mutant were cloned expressed in Chinese hamster ovary cells. Supernatants applied heparin-agarose affinity columns their...
Coagulase-negative staphylococci (CoNS) are an infrequent cause of native valve endocarditis (NVE), and our understanding NVE caused by CoNS is incomplete.The International Collaboration on Endocarditis-Prospective Cohort Study includes patients with from 61 centers in 28 countries. Patients definite cases who were enrolled during the period June 2000-August 2006 compared Staphylococcus aureus viridans group streptococci. Multivariable logistic regression was used to determine factors...