G. A. Hitman
A5064649684- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolism, Diabetes, and Cancer
- Diabetes Management and Research
- Lipoproteins and Cardiovascular Health
- Genetic Associations and Epidemiology
- Diabetes Treatment and Management
- Gestational Diabetes Research and Management
- Birth, Development, and Health
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Vitamin D Research Studies
- Inflammasome and immune disorders
- Diet, Metabolism, and Disease
- Peroxisome Proliferator-Activated Receptors
- Diet and metabolism studies
- Epigenetics and DNA Methylation
- Pregnancy and preeclampsia studies
- Celiac Disease Research and Management
- Cancer, Lipids, and Metabolism
- Health Systems, Economic Evaluations, Quality of Life
- Bariatric Surgery and Outcomes
- Diabetes Management and Education
- Liver Disease Diagnosis and Treatment
Queen Mary University of London
2016-2025
Nuffield Health
2024
National Health and Medical Research Council
2024
Genomics (United Kingdom)
2020
Royal London Hospital
1995-2019
Barts Health NHS Trust
2008-2019
Diabetes UK
2010-2015
St Bartholomew's Hospital
1983-2015
Rosalind Franklin University of Medicine and Science
2013
Academic Medical Center
2013
Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for type 2 diabetesâsusceptibility genes identified variant in FTO (fat mass and associated) gene predisposes diabetes through an effect on body index (BMI). An additive association with BMI was replicated 13 cohorts 38,759 participants. 16% adults who homozygous allele weighed about 3 kilograms more...
The molecular mechanisms involved in the development of type 2 diabetes are poorly understood. Starting from genome-wide genotype data for 1924 diabetic cases and 2938 population controls generated by Wellcome Trust Case Control Consortium, we set out to detect replicated association signals through analysis 3757 additional 5346 integration our findings with equivalent other international consortia. We detected susceptibility loci around genes CDKAL1, CDKN2A/CDKN2B, IGF2BP2 confirmed...
The genes ABCC8 and KCNJ11, which encode the subunits sulfonylurea receptor 1 (SUR1) inwardly rectifying potassium channel (Kir6.2) of β-cell ATP-sensitive (KATP) channel, control insulin secretion. Common polymorphisms in these (ABCC8 exon 16–3t/c, 18 T/C, KCNJ11 E23K) have been variably associated with type 2 diabetes, but no large (∼2,000 subjects) case-control studies performed. We evaluated role three variants by studying 2,486 U.K. subjects: 854 1,182 population subjects, 150...
Exposure of a developing foetus to maternal gestational diabetes (GDM) has been shown programme future risk and obesity. Epigenetic variation in foetal tissue may have mechanistic role metabolic disease programming through interaction the pregnancy environment with gene function. We aimed identify genome-wide DNA methylation cord blood placenta from offspring born mothers without GDM. Pregnant women South Asian origin were studied tissues sampled at term delivery. The Illumina...
Bayesian networks (BNs) have received increasing research attention that is not matched by adoption in practice and yet potential to significantly benefit healthcare. Hitherto, works investigated the types of medical conditions being modelled with BNs, nor whether there are any differences how why they applied different conditions. This seeks identify quantify range for which healthcare-related BN models been proposed, approach between most common applied. We found almost two-thirds all...
Previous meta-analyses of summary data from randomised controlled trials have shown that statin therapy increases the risk diabetes, but less is known about size or timing this effect, who at greatest risk. We aimed to address these gaps in knowledge through analysis individual participant large, long-term, randomised, double-blind therapy.
Abstract Objective Familial cold urticaria (FCU) and Muckle‐Wells syndrome (MWS) are dominantly inherited autoinflammatory disorders that cause rashes, fever, arthralgia, in some subjects, AA amyloidosis, have been mapped to chromosome 1q44. Sensorineural deafness MWS, provocation of symptoms by FCU, distinctive features. This study was undertaken characterize the genetic basis an overlapping disorder French Canadian, British, Indian families, respectively. Methods Mutations candidate gene...
Associations have been reported between vitamin D receptor (VDR) gene polymorphisms, type 1 diabetes, insulin secretion, and the resistance syndrome. As VDR polymorphisms no known functional significance, these findings may implicate a variant of or locus in linkage disequilibrium with VDR. We examined mRNA protein levels relation to (41 Bangladeshi subjects) analyzed secretory capacity (143 subjects), allowing for other determinants. Peripheral blood mononuclear cells (PBMCs) from subjects...
A limited number of studies have assessed the risk common diseases when combining information from several predisposing polymorphisms. In most cases, individual polymorphisms only moderately increase (approximately 20%), and they are thought to be unhelpful in assessing individuals' clinically. The value analyzing multiple alleles simultaneously is not well studied. This often because, for any given disease, very few been confirmed.
Recent data suggest that common variation in the transcription factor 7-like 2 (TCF7L2) gene is associated with type diabetes. Evaluation of such associations independent samples provides necessary replication and a robust assessment effect size. Using four TCF7L2 single nucleotide polymorphisms (SNPs; including two most previous study), we conducted case-control study 2,158 diabetic subjects 2,574 control family-based association analysis 388 parent-offspring trios all from U.K. All SNPs...