A5076798733- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Obesity and Health Practices
- Bariatric Surgery and Outcomes
- Obesity, Physical Activity, Diet
- Behavioral Health and Interventions
- Diabetes Management and Education
- Health Systems, Economic Evaluations, Quality of Life
- Health Promotion and Cardiovascular Prevention
- Palliative Care and End-of-Life Issues
- Smoking Behavior and Cessation
- Nutritional Studies and Diet
- Lung Cancer Diagnosis and Treatment
- Retinal and Optic Conditions
- Chronic Disease Management Strategies
- Lung Cancer Treatments and Mutations
- Blood Pressure and Hypertension Studies
- BRCA gene mutations in cancer
- Rheumatoid Arthritis Research and Therapies
- Glaucoma and retinal disorders
- Physical Activity and Health
- Diabetes Treatment and Management
- Colorectal Cancer Screening and Detection
- Diet and metabolism studies
- Diabetes Management and Research
Cicely Saunders International
2021-2025
King's College London
2014-2025
Guy's and St Thomas' NHS Foundation Trust
2014-2023
Creative Commons
2023
Imperial College London
2016-2023
Imperial College Healthcare NHS Trust
2023
University College London
2009-2023
University College Hospital
2023
St Thomas' Hospital
2019-2023
Vienna General Hospital
2023
To prospectively evaluate the incidence, spectrum of disease and relation to general health shoulder disorders in primary care.Patients presenting with pain two large practices Cambridge area over a 1-month period were invited participate. After consulting their practitioner, patients administered demographic information questionnaire, disability index (SPADI) short form 36 (SF-36) survey. Subsequent review clinic held by rheumatology registrar every 2 weeks was undertaken.The sex-...
We examined the probability of an obese person attaining normal body weight.We drew a sample individuals aged 20 years and older from United Kingdom's Clinical Practice Research Datalink 2004 to 2014. analyzed data for 76,704 men 99,791 women. excluded participants who received bariatric surgery. estimated weight or 5% reduction in weight.During maximum 9 years' follow-up, 1283 2245 women attained weight. In simple obesity (body mass index = 30.0-34.9 kg/m(2)), annual was 1 210 124 women,...
Screening for prostate cancer using prostate-specific antigen (PSA) testing can lead to problems of underdiagnosis and overdiagnosis. Short, noncontrast magnetic resonance imaging (MRI) or transrectal ultrasonography might overcome these limitations.To compare the performance PSA testing, MRI, as screening tests cancer.This prospective, population-based, blinded cohort study was conducted at 7 primary care practices 2 centers in United Kingdom. Men 50 69 years age were invited from October...
BackgroundIndividuals with serum antibodies to citrullinated protein antigens (ACPA), rheumatoid factor, and symptoms, such as inflammatory joint pain, are at high risk of developing arthritis. In the arthritis prevention in pre-clinical phase abatacept (APIPPRA) trial, we aimed evaluate feasibility, efficacy, acceptability treating individuals T-cell co-stimulation modulator abatacept.MethodsThe APIPPRA study was a randomised, double-blind, multicentre, parallel, placebo-controlled, 2b...
Dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) are adrenal precursors of steroid biosynthesis centrally acting neurosteroids. Glucocorticoid mineralocorticoid deficiencies in Addison’s disease require life-long hormone replacement, but the associated failure synthesis is not corrected. We conducted a randomized, double blind study which 39 patients with received either 50 mg oral daily for 12 weeks, followed by 4-week washout period, then weeks placebo, or vice versa. After...
Previous epidemiological studies have demonstrated relationships between individual nutrients and glucose intolerance type 2 diabetes, but the association with overall pattern of dietary intake has not previously been described. In order to characterize this association, 802 subjects aged 40–65 years were randomly selected from a population-based sampling frame underwent 75 g oral glucose-tolerance test. Principal component analysis was used identify four patterns explaining 31·7 % variation...
<b>Objectives</b> To describe independent predictors for the development of microalbuminuria and progression to macroalbuminuria in those with childhood onset type 1 diabetes. <b>Design</b> Prospective observational study follow-up 9.8 (SD 3.8) years. <b>Setting</b> Oxford regional prospective study. <b>Participants</b> 527 participants a diagnosis diabetes at mean age 8.8 4.0) <b>Main outcome measures</b> Annual measurement glycated haemoglobin (HbA<sub>1c</sub>) assessment urinary...
Assessing fidelity of behavioural interventions is important, but demanding and rarely done. This study assessed adherence to behaviour change techniques used in an intervention increase physical activity among sedentary adults ( ProActive ; N = 365). Transcripts 108 sessions with a sub-sample 27 participants were assessed. An independent assessor coded four 'facilitators' who delivered the 208 protocol-specified facilitator behaviours (e.g. 'elicit perceived advantages becoming more...
Breathlessness is common in advanced cancer. The Intervention Service (BIS) a multi-disciplinary complex intervention theoretically underpinned by palliative care approach, utilising evidence-based non-pharmacological and pharmacological interventions to support patients with disease. We sought establish whether BIS was more effective, cost-effective, for cancer their carers than standard care. A single-centre Phase III fast-track single-blind mixed-method randomised controlled trial (RCT)...
Background.Multimorbidity is the co-occurrence of long-term conditions. Obesity associated with an increased risk conditions including type 2 diabetes and depression.
Journal Article Randomized Controlled Trial Evaluation of a Tailored Leaflet and SMS Text Message Self-help Intervention for Pregnant Smokers (MiQuit) Get access Felix Naughton, Ph.D., Ph.D. 1General Practice Primary Care Research Unit, Institute Public Health, University Cambridge, United Kingdom Search other works by this author on: Oxford Academic PubMed Google Scholar A. Toby Prevost, Kingdom2Department Health Sciences, King’s College London, Hazel Gilbert, 3Department Population Royal...
Objective To determine whether the incidence of pneumonia, peritonsillar abscess, mastoiditis, empyema, meningitis, intracranial and Lemierre’s syndrome is higher in general practices that prescribe fewer antibiotics for self limiting respiratory tract infections (RTIs). Design Cohort study. Setting 610 UK from Clinical Practice Research Datalink. Participants Registered patients with 45.5 million person years follow-up 2005 to 2014. Exposures Standardised proportion RTI consultations...
BackgroundMeta-analyses have identified promising behavior change techniques (BCTs) in changing obesity-related behaviors from intervention descriptions. However, it is unclear whether these BCTs are used by participants and related to outcomes.
Breathlessness is the most common and intrusive symptom of advanced non-malignant respiratory cardiac conditions. The Intervention Service (BIS) a multi-disciplinary complex intervention, theoretically underpinned by palliative care approach, utilising evidence-based non-pharmacological pharmacological interventions to support patients with disease in managing their breathlessness. Having published effectiveness cost BIS for cancer carers, we sought establish its effectiveness,
Objectives To investigate access to weight management interventions for overweight and obese patients in primary care. Setting UK care electronic health records. Participants A cohort of 91 413 aged 30–100 years was sampled from the Clinical Practice Research Datalink (CPRD). Patients with body mass index (BMI) values ≥25 kg/m 2 recorded between 2005 2012 were included. BMI categorised using WHO criteria. Interventions management, including advice, referrals prescription antiobesity drugs,...