A5103181674- Rheumatoid Arthritis Research and Therapies
- Bone health and osteoporosis research
- Systemic Lupus Erythematosus Research
- Vitamin D Research Studies
- Nutritional Studies and Diet
- Bone health and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Autoimmune and Inflammatory Disorders Research
- Diet and metabolism studies
- Bone Metabolism and Diseases
- Vasculitis and related conditions
- Otitis Media and Relapsing Polychondritis
- Obesity, Physical Activity, Diet
- Chronic Lymphocytic Leukemia Research
- Cancer Treatment and Pharmacology
- Biosimilars and Bioanalytical Methods
- Nutrition and Health in Aging
- Systemic Sclerosis and Related Diseases
- HER2/EGFR in Cancer Research
- Diabetes Treatment and Management
- Hip and Femur Fractures
- Blood groups and transfusion
- Platelet Disorders and Treatments
- Inflammatory mediators and NSAID effects
- Musculoskeletal synovial abnormalities and treatments
MRC Epidemiology Unit
2019-2025
University of Cambridge
2019-2025
Johns Hopkins University
2005-2024
Johns Hopkins Medicine
2005-2024
National Health Service
2023
Technical Design (United States)
2021
PeaceHealth St. John Medical Center
2021
Great Western Hospital
2008-2020
MRC Human Nutrition Research
2018-2020
Medical Research Council
2019
BackgroundIndividuals with serum antibodies to citrullinated protein antigens (ACPA), rheumatoid factor, and symptoms, such as inflammatory joint pain, are at high risk of developing arthritis. In the arthritis prevention in pre-clinical phase abatacept (APIPPRA) trial, we aimed evaluate feasibility, efficacy, acceptability treating individuals T-cell co-stimulation modulator abatacept.MethodsThe APIPPRA study was a randomised, double-blind, multicentre, parallel, placebo-controlled, 2b...
OBJECTIVE: The Diabetes Prevention Program (DPP) is a 27-center randomized clinical trial designed to evaluate the safety and efficacy of interventions that may delay or prevent development diabetes in people at increased risk for type 2 diabetes. RESEARCH DESIGN AND METHODS: Eligibility requirements were age > = 25 years, BMI 24 kg/m2 (> 22 Asian-Americans), impaired glucose tolerance plus fasting plasma 5.3-6.9 mmol/l (or < 6.9 mmol American Indians). Randomization...
Monitoring dietary intake of sugars in the population's diet has great importance evaluating efficiency national sugar reduction programmes. The study objective was to provide a comprehensive assessment sources added and free assess adherence public health recommendations UK population consider impact different definitions on monitoring. terms "added sugar" "free are which include components may result intakes depending definition. Dietary sugars, seven individual (sugar from table sugar;...
Prostaglandins (PG) act as direct inhibitors of mature osteoclasts, but although resorption-inhibition is also observed initially PG increase bone resorption in organ culture. This suggests that influence culture through actions on cell types other than osteoclasts. We have therefore tested the effects E1, E2, and F2 alpha differentiation osteoclastic phenotype mouse marrow cultures using calcitonin receptors (CTR) markers differentiation. found PGE2 (10(-6)-10(-9) M) PGE1 (10(-6)-10(-7)...
GPR119 receptor agonists improve glucose metabolism and alter gut hormone profiles in animal models healthy subjects. We therefore investigated the pharmacology of GSK1292263 (GSK263), a selective agonist, two randomized, placebo-controlled studies that enrolled subjects with type 2 diabetes. Study 1 had drug-naive or who stopped their diabetic medications, taking metformin. GSK263 was administered as single (25–800 mg; n = 45) multiple doses (100–600 mg/day for 14 days; 96). Placebo...
Access to rheumatology services in Canada is becoming increasingly challenging due the rising burden of rheumatic and musculoskeletal diseases (RMDs) a rapidly growing population, workforce supply deficit that projected worsen coming years. Specialist physician remuneration has been demonstrated influence practices, thereby affecting access health quality care. Hence, we sought compare fee-for-service structures across provinces Canada. We performed an environmental scan publicly-funded...
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ABSTRACT Since 1970 Mycoplasma fermentans has been suspected of being associated with rheumatoid arthritis. However, this association difficult to prove, and our goal. The distribution M. was studied in the synovial fluid patients suffering from different arthritides. Samples were taken well-defined disease a clear diagnosis. After removal inflammatory cells hyaluran, they treated proteinase K tested by single or fully nested PCR primers directed against part two 16S rRNA genes . product...
Abstract Osteoclastic differentiation is induced from hematopoietic cells in the presence of 1,25-(OH)2D3 by stromal that are present bone but not spleen. Recent evidence suggests prostaglandins (PGs) essential for this process. In communication we describe experiments which have examined further role PGE2 osteoclast formation. We found a marked reduction basal, 1,25-(OH)2D3, and IL-3-induced production calcitonin receptor (CTR)-positive resorption cyclooxygenase inhibitors, was restored...
1. This work investigated the drug interaction potential of GSK1292263, a novel GPR119 agonist, with HMG-coA reductase inhibitors simvastatin and rosuvastatin.2. In vitro experiments assessed inhibition transporters CYP enzymes by clinical study effect GSK1292263 (300 mg BID) on pharmacokinetic profile (40 single dose) rosuvastatin (10 dose).3. vitro, demonstrated little/weak (IC50 values >30 μM) towards CYPs (CYP1A2, 2C9, 2C19, 2D6, 3A4), Pgp, OATP1B3, or OCT2. However, inhibited BCRP...
Little is known about population levels of energy expenditure, as national surveillance systems typically employ only crude measures. The National Diet and Nutrition Survey (NDNS) in the UK measured expenditure a 10% subsample by gold-standard doubly labelled water (DLW).DLW-subsample participants from NDNS (383 males, 387 females) aged 4-91 years were recruited between 2008 2015 (rolling programme). Height weight body-fat percentage estimated deuterium dilution.Absolute total (TEE)...
Summary A new switching criterion for adaptive-implicit reservoir simulation, based on the numerical stability of local amplification matrix, is discussed. Adaptive-implicit methods can be used to achieve substantial savings in computing time and storage. The success their application, however, depends critically an appropriate criterion. standard discussed literature application threshold changes primary variables, which are usually determined by some preliminary testing chosen...
The effect of fluoroquinolone use on the susceptibility Pseudomonas aeruginosa to fluoroquinolones in U.S. hospitals was studied. Benchmarking surveys were sent annually pharmacists practicing from 1993 1999. Data collected included hospital characteristics, antimicrobial expenditures and use, stewardship activities, bacterial susceptibilities. Antimicrobial normalized for number occupied beds (OBs) per year. General linear modeling repeated-measures mixed-effects used determine factors...
Abstract The osteoclast is known to be derived from the hematopoietic stem cell, but its lineage remains controversial. There evidence that osteoclastic differentiation induced through a contact-dependent interaction between bone marrow stromal cells and precursors. To analyze lineage, colonies were generated in semisolid medium mouse spleen presence of Wehi-conditioned medium, interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor (GM-CSF), or macrophage (M-CSF) with without...
By use of a very sensitive nested PCR method targeting part the strongly conserved mycoplasmal 16S RNA genes, Mycoplasma pneumoniae was found in synovial fluid 19/24 (79%) rheumatoid arthritis patients, 6/6 (100%) patients with nonrheumatoid inflammatory arthritis, and 8/10 (80%) osteoarthritis attending rheumatology clinic for drainage joint effusions. It not exudates 13 people orthopedic traumatic knee injuries or undergoing surgery replacement. However, M. detected 2/4 biopsy specimens...