Coziana Ciurtin
A5083838326- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Spondyloarthritis Studies and Treatments
- Salivary Gland Disorders and Functions
- Atherosclerosis and Cardiovascular Diseases
- Systemic Sclerosis and Related Diseases
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Adolescent and Pediatric Healthcare
- Diabetes and associated disorders
- Inflammasome and immune disorders
- Bone and Joint Diseases
- Psoriasis: Treatment and Pathogenesis
- Orthopedic Surgery and Rehabilitation
- Fibromyalgia and Chronic Fatigue Syndrome Research
- COVID-19 Clinical Research Studies
- Lipid metabolism and disorders
- Liver Disease Diagnosis and Treatment
- Musculoskeletal synovial abnormalities and treatments
- Renal Diseases and Glomerulopathies
- Liver Diseases and Immunity
- Salivary Gland Tumors Diagnosis and Treatment
- Inflammatory Myopathies and Dermatomyositis
Versus Arthritis
2019-2025
University College London
2016-2025
Great Ormond Street Hospital
2019-2025
University College Hospital
2016-2025
University College London Hospitals NHS Foundation Trust
2016-2025
Center for Rheumatology
2021-2025
Royal London Hospital
2018-2024
Ross School
2024
University of London
2021-2024
Science Health Allied Research Education
2023
Zoonotic introduction of novel coronaviruses may encounter preexisting immunity in humans. Using diverse assays for antibodies recognizing SARS-CoV-2 proteins, we detected humoral immunity. spike glycoprotein (S)-reactive were detectable using a flow cytometry-based method SARS-CoV-2-uninfected individuals and particularly prevalent children adolescents. They predominantly the immunoglobulin G (IgG) class targeted S2 subunit. By contrast, infection induced higher titers S-reactive IgG...
BackgroundIndividuals with serum antibodies to citrullinated protein antigens (ACPA), rheumatoid factor, and symptoms, such as inflammatory joint pain, are at high risk of developing arthritis. In the arthritis prevention in pre-clinical phase abatacept (APIPPRA) trial, we aimed evaluate feasibility, efficacy, acceptability treating individuals T-cell co-stimulation modulator abatacept.MethodsThe APIPPRA study was a randomised, double-blind, multicentre, parallel, placebo-controlled, 2b...
Type 1 interferons (IFN) are an antiviral cytokine family, important in juvenile onset systemic lupus erythematosus (jSLE) which is more common females, around puberty. We report that plasmacytoid dendritic cells (pDC) from healthy females produced type IFN after toll like receptor (TLR) 7 signaling than males, even before puberty, but puberty itself associated with increased production of IFN. A unique human model allows us to show this was related X chromosome number, and serum...
Background Systemic lupus erythematous (SLE) is a systemic autoimmune/inflammatory condition. Approximately 15–20% of patients develop symptoms before their 18th birthday and are diagnosed with juvenile-onset SLE (JSLE). Gender distribution, clinical presentation, disease courses outcomes vary significantly between JSLE individuals adult-onset SLE. This study aimed to identify age-specific and/or serological patterns in enrolled the UK Cohort Study. Methods Patient records were accessed...
We present a study protocol for multi-centre, randomised, double-blind, parallel-group, placebo-controlled trial that seeks to test the feasibility, acceptability and effectiveness of 52-week period treatment with first-in-class co-stimulatory blocker abatacept preventing or delaying onset inflammatory arthritis. The aimed recruit 206 male female subjects from secondary care hospital setting across UK Netherlands. Participants who were at least 18 years old, reported sounding joint pain...
Abstract Several related human coronaviruses (HCoVs) are endemic in the population, causing mild respiratory infections 1 . Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), etiologic agent of disease 2019 (COVID-19), is a recent zoonotic infection that has quickly reached pandemic proportions 2,3 Zoonotic introduction novel thought to occur absence pre-existing immunity target population. Using diverse assays for detection antibodies reactive with SARS-CoV-2 spike (S)...
BackgroundSexual dimorphisms, which vary depending on age group and pubertal status, have been described across both the innate adaptive immune system. We explored influence of sex hormones phenotype in context adolescent health autoimmunity.MethodsIn this cross-sectional study, healthy, post-pubertal cisgender individuals (aged 16–25 years); pre-pubertal 6–11 transgender 18–19 years) undergoing gender-affirming treatment (testosterone assigned female at birth oestradiol male birth); 14–25...
Musculoskeletal diseases affect up to 20% of adults worldwide. The gut microbiome has been implicated in inflammatory conditions, but large-scale metagenomic evaluations have not yet traced the routes by which immunity affects arthritis. To characterize community structure and associated functional processes driving microbial involvement arthritis, Inflammatory Arthritis Microbiome Consortium investigated 440 stool shotgun metagenomes comprising 221 diagnosed with rheumatoid ankylosing...
Abstract Sjögren disease (SD) is a chronic, autoimmune of unknown aetiology with significant impact on quality life. Although dryness (sicca) the eyes and mouth are classically described features, other mucosal surfaces systemic manifestations common. The key management aim should be to empower individual manage their condition—conserving, replacing stimulating secretions; preventing damage suppressing activity. This guideline builds widens recommendations developed for first published in...
Systemic lupus erythematosus (SLE) is a systemic autoimmune/inflammatory disease. Patients diagnosed with juvenile-onset SLE (jSLE), when compared to individuals adult-onset SLE, develop more severe organ involvement, increased disease activity and greater tissue damage. In clinical characteristics, pathomechanisms, progression outcomes do not only vary between age groups, but also ethnicities. However, in children young people, the influence of ethnicity on onset, phenotype outcome has been...