Eslam Al‐Abadi
A5091100617- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Kawasaki Disease and Coronary Complications
- COVID-19 Clinical Research Studies
- Inflammasome and immune disorders
- Immunodeficiency and Autoimmune Disorders
- Renal Diseases and Glomerulopathies
- Adolescent and Pediatric Healthcare
- Systemic Sclerosis and Related Diseases
- COVID-19 Impact on Reproduction
- Atherosclerosis and Cardiovascular Diseases
- Vasculitis and related conditions
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Acute Lymphoblastic Leukemia research
- Otitis Media and Relapsing Polychondritis
- Rheumatoid Arthritis Research and Therapies
- Coronary Artery Anomalies
- Intensive Care Unit Cognitive Disorders
- Mechanical Circulatory Support Devices
- Ocular Diseases and Behçet’s Syndrome
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- interferon and immune responses
- Dermatological and Skeletal Disorders
Birmingham Children's Hospital
2017-2025
Birmingham Women’s and Children’s NHS Foundation Trust
2019-2024
University of Birmingham
2020-2023
Cancer Research UK Clinical Trials Unit
2020-2021
Boston Children's Hospital
2013
Children were relatively spared during COVID-19 pandemic. However, the recently reported hyperinflammatory syndrome with overlapping features of Kawasaki disease and toxic shock syndrome-"Paediatric Inflammatory Multisystem Syndrome-temporally associated SARS-CoV-2" (PIMS-TS) has caused concern. We describe cardiac findings short-term outcomes in children PIMS-TS at a tertiary children's hospital. Single-center observational study from 10th April to 9th May 2020. Data on ECG echocardiogram...
Background Systemic lupus erythematous (SLE) is a systemic autoimmune/inflammatory condition. Approximately 15–20% of patients develop symptoms before their 18th birthday and are diagnosed with juvenile-onset SLE (JSLE). Gender distribution, clinical presentation, disease courses outcomes vary significantly between JSLE individuals adult-onset SLE. This study aimed to identify age-specific and/or serological patterns in enrolled the UK Cohort Study. Methods Patient records were accessed...
Multisystem inflammatory syndrome in children (MIS-C) is a life-threatening disease occurring several weeks after severe acute respiratory coronavirus 2 (SARS-CoV-2) infection. Deep immune profiling showed MIS-C patients had highly activated neutrophils, classical monocytes and memory CD8+ T-cells, with increased frequencies of B-cell plasmablasts double-negative B-cells. Post treatment samples from the same patients, taken during symptom resolution, identified recovery-associated features...
Systemic lupus erythematosus (SLE) is a systemic autoimmune/inflammatory disease. Patients diagnosed with juvenile-onset SLE (jSLE), when compared to individuals adult-onset SLE, develop more severe organ involvement, increased disease activity and greater tissue damage. In clinical characteristics, pathomechanisms, progression outcomes do not only vary between age groups, but also ethnicities. However, in children young people, the influence of ethnicity on onset, phenotype outcome has been...
We report the safety, tolerability and efficacy of tofacitinib in patients with juvenile idiopathic arthritis (JIA) an ongoing long-term extension (LTE) study.
To evaluate the impact of anti-Tumour Necrosis Factor-α (anti-TNF) treatment on occurrence vasculitic ischaemic events in patients with deficiency adenosine deaminase 2 (DADA2).A retrospective analysis DADA2 referred from six centres to Great Ormond Street Hospital for Children was conducted. Ischaemic events, disease activity, biochemical, immunological, and radiological features were compared, before after anti-TNF treatment.A total 31 genetically confirmed included study. The median...
Background During the COVID-19 outbreak, reports have surfaced of children who present with features a multisystem inflammatory syndrome overlapping Kawasaki disease and toxic shock – Paediatric Inflammatory Multisystem Syndrome-temporally associated SARS-CoV-2 pandemic (PIMS-TS). Initial find that many are PCR-negative for SARS-CoV-2, so it is difficult to confirm whether this late complication viral infection in an age group largely spared worst consequences infection, or if reflects...
Juvenile-onset systemic lupus erythematosus (JSLE) is more severe than adult-onset disease, including nephritis (LN). Despite differences in phenotype/pathogenesis, treatment based upon adult trials. This study aimed to compare response, damage accrual, time inactive LN and subsequent flare, JSLE patients treated with mycophenolate mofetil (MMF) versus intravenous cyclophosphamide (IVCYC).UK Cohort Study participants, ≤16 years at diagnosis, ≥4 American College of Rheumatology criteria for...
Abstract Objectives Juvenile-onset systemic lupus erythematosus (jSLE) affects 15–20% of patients. Clinical heterogeneity between racial groups, age groups and individual patients suggests variable pathophysiology. This study aimed to identify highly penetrant damaging mutations in genes associated with SLE/SLE-like disease a large national cohort (UK JSLE Cohort Study) compare demographic, clinical laboratory features patient sub-cohorts ‘genetic’ SLE vs remaining Methods Based on...
To validate novel childhood-onset systemic lupus erythematosus (cSLE) T2T targets including Childhood Lupus Low Disease Activity State (cLLDAS), cSLE Clinical Remission on steroids (cCR), and off (cCR-0), as compared with adult-onset SLE (aSLE) targets. Attainment of the aforementioned cSLE-specific aSLE-specific (LLDAS, DORIS 2021 Remission) was assessed at each visit, in UK JSLE Cohort Study patients. Univariable multivariable Prentice-Williams-Peterson (PWP) gap-time models investigated...
Juvenile-onset systemic lupus erythematosus (JSLE) is a rare autoimmune/inflammatory disease with significant morbidity and mortality. Neuropsychiatric (NP) involvement severe complication, encompassing heterogeneous range of neurological psychiatric manifestations.
To assess the achievability and effect of attaining low disease activity (LDA) or remission in childhood-onset SLE (cSLE).
This study aimed to test the performance of new ACR and EULAR criteria, that include ANA positivity as entry criterion, in JSLE.
Abstract Coronavirus disease 2019 (COVID-19) has caused mild illness in children, until the emergence of novel hyperinflammatory condition paediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory coronavirus 2 (SARS-CoV-2) (PIMS-TS). PIMS-TS is thought to be a post-SARS-CoV-2 immune dysregulation excessive cytokine release. We studied 25 hydroxyvitamin D (25OHD) concentrations children PIMS-TS, admitted tertiary hospital UK, due its postulated role...
Objectives The Systemic Lupus International Collaborating Clinics (SLICC) group proposed revised classification criteria for systemic lupus erythematosus (SLICC-2012 criteria). This study aimed to compare these with the well-established American College of Rheumatology (ACR-1997 criteria) in a national cohort juvenile-onset (JSLE) patients and evaluate how patients’ evolved over time. Methods Data from UK JSLE Cohort Study senior clinician diagnosis probable evolving, or definite JSLE, were...
In the absence of clinical trials evidence, Juvenile-onset Systemic Lupus Erythematosus (JSLE) treatment plans vary.
Abstract Objective We sought to explore patient and parental views on treatment targets, outcome measures study designs being considered for a future JSLE treat-to-target (T2T) study. Methods conducted topic-guided, semistructured interviews with patients parents analysed the audio recorded using thematic approaches. Results Patients differed regarding symptoms they felt would be tolerable, representing ‘low disease activity’. often classed that had previously experienced, were ‘invisible’...
To derive childhood-onset SLE (cSLE) specific remission definitions for future treat-to-target (T2T) trials, observational studies, and clinical practice.
Cellular phenotype and function are altered in different microenvironments. For targeted therapies it is important to understand site-specific cellular adaptations. Juvenile idiopathic arthritis (JIA) characterized by autoimmune joint inflammation, with frequent inadequate treatment responses. To comprehensively assess the inflammatory immune landscape, we designed a 37-parameter spectral flow cytometry panel delineating mononuclear cells from JIA synovial fluid (SF) of inflamed joints,...
Abstract Objective Several monogenic autoinflammatory disorders and primary immunodeficiencies can present early in life with features that may be mistaken for Behçet’s disease (BD). We aimed to develop a genetic analysis workflow identify rare BD-like diseases establish the contribution of HLA haplotype cohort patients from UK. Methods Patients clinically suspected BD were recruited four specialist care centres All participants underwent whole-exome sequencing (WES), thereafter by (i)...