A5019339083- Systemic Lupus Erythematosus Research
- Monoclonal and Polyclonal Antibodies Research
- Platelet Disorders and Treatments
- Rheumatoid Arthritis Research and Therapies
- Renal Diseases and Glomerulopathies
- Blood disorders and treatments
- Autoimmune and Inflammatory Disorders Research
- Biosimilars and Bioanalytical Methods
- Diabetes and associated disorders
- Cell Adhesion Molecules Research
- Peripheral Neuropathies and Disorders
- Chronic Lymphocytic Leukemia Research
- COVID-19 Clinical Research Studies
- Pregnancy and Medication Impact
- Lymphoma Diagnosis and Treatment
- Vasculitis and related conditions
- SARS-CoV-2 and COVID-19 Research
- Amyotrophic Lateral Sclerosis Research
- Liver Diseases and Immunity
- Heparin-Induced Thrombocytopenia and Thrombosis
- Immunodeficiency and Autoimmune Disorders
- Chemotherapy-induced cardiotoxicity and mitigation
- Osteoarthritis Treatment and Mechanisms
- Cytokine Signaling Pathways and Interactions
- Acute Lymphoblastic Leukemia research
Lombardia Informatica (Italy)
2025
Regione Lombardia
2025
University of Milan
2007-2023
IRCCS Istituto Auxologico Italiano
2013-2022
Istituti di Ricovero e Cura a Carattere Scientifico
2013-2022
Center for Environmental Health
2021
Critically ill patients with coronavirus disease 2019 (COVID-19) have a profound hypercoagulable state and often develop coagulopathy which leads to organ failure death. Because of prolonged activated partial-thromboplastin time (aPTT), relationship anti-phospholipid antibodies (aPLs) has been proposed, but results are controversial. Functional assays for aPL (i.e., lupus anticoagulant) can be influenced by concomitant anticoagulation and/or high levels C reactive protein. The presence...
Objective It has been suggested that only antibodies against domain 1 (D1) of β 2 ‐glycoprotein I (β GPI) are pathogenic and diagnostic. The role other GPI domains is still debated. This study was undertaken to evaluate the clinical relevance specificity profiling anti‐β IgG in antiphospholipid syndrome (APS) patients control groups with systemic autoimmune rheumatic diseases asymptomatic antibody (aPL) carriers. Methods We evaluated 159 subjects persistently positive, medium or high‐titer...
To evaluate the 12-year survival of first tumor necrosis factor inhibitor (TNFi) treatment in a cohort rheumatoid arthritis (RA) patients, comparing between-groups discontinuation rates for infliximab, etanercept, and adalimumab.RA patients treated with their TNFi were investigated from local registry. Before after adjusting propensity scores, overall by individual drug retention was evaluated. Drug calculated using Kaplan-Meier method compared Cox extended model. Subanalyses performed...
Objective Isolated hypogonadotropic hypogonadism (IHH) is a rare disorder with pubertal delay, normal (normoosmic-IHH, nIHH) or defective sense of smell (Kallmann syndrome, KS). Other reproductive and non-reproductive anomalies might be present although information on their frequency are scanty, particularly according to the age presentation. Design Observational cohort study carried out between January 2008 June 2016 within national network academic general hospitals. Methods We performed...
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal neurodegenerative diseases characterized by the presence of neuropathological aggregates phosphorylated TDP-43 (P-TDP-43) protein. The RNA-binding protein participates also to cell stress response forming granules (SG) in cytoplasm temporarily arrest translation. hypothesis that pathology directly arises from SG has been proposed but is still under debate because only sub-lethal conditions have tested...
Introduction Currently available clinical assays to detect antiphospholipid antibodies (aPL) test for IgG and IgM cardiolipin (aCL) β2-glycoprotein I (aβ2GPI). It has been suggested that testing IgA aPL Domain (DI), which carries the key antigenic epitopes of β2GPI, could add value these current tests. We performed an observational, multicenter cohort study evaluate utility IgG, each CL, β2GPI DI in APS. Methods Serum from 230 patients with APS (n = 111), SLE but not 119), 200 healthy...
Abstract Objectives aPL, the serum biomarkers of APS, are most common acquired causes pregnancy morbidity (PM). This study investigates impact aPL positivity fulfilling classification criteria (‘criteria aPL’) and at titres lower than thresholds considered by (‘low-titre on PM assesses effectiveness low-dose aspirin (LDASA), low molecular weight heparin (LMWH) HCQ in reducing probability (PPM). Methods Longitudinal data 847 pregnancies 155 women with persistent any titre 226 autoimmune...
Objectives To define the correlation between joint ultrasonography and clinical examination in patients with juvenile idiopathic arthritis (JIA) to assess whether synovitis detected by clinically inactive predicts flares. Methods 88 consecutive JIA—46 (52%) persistent oligoarthritis, 15 (17%) extended rheumatoid factor-negative polyarthritis 12 (14%) other forms of JIA, all for a minimum 3 months—underwent ultrasound (US) assessment 44 joints. Joints were scanned at study entry synovial...
Clinical studies have reported different diagnostic/predictive values of antibodies to domain 1 or 4/5 β2glycoproteinI in terms risk thrombosis and pregnancy complications patients with antiphospholipid syndrome. To obtain direct evidence for the pathogenic role anti-domain antibodies, we analyzed vivo pro-coagulant effect two groups 5 sera IgG each reacting selectively lipopolysaccharide (LPS)-treated rats. Antibody-induced thrombus formation mesenteric vessels was followed by intravital...
Antiphospholipid syndrome (APS) is a chronic and disabling condition characterized by recurrent thrombosis miscarriages mediated antibodies against phospholipid-binding proteins (aPL), such as beta2glycoprotein I (β2GPI). Complement involved in APS animal models complement deposits have been documented placenta thrombotic vessels despite normal serum levels. Analysis of circulating blood cells coated with C4d displays higher sensitivity than the conventional assays that measure soluble...
Juvenile-onset systemic lupus erythematosus (JSLE) is a rare autoimmune/inflammatory disease with significant morbidity and mortality. Neuropsychiatric (NP) involvement severe complication, encompassing heterogeneous range of neurological psychiatric manifestations.
The present study was undertaken to longitudinally evaluate titers of antibodies against β2 -glycoprotein I (anti-β2 GPI) and domain 1 (anti-D1), identify predictors variations in anti-β2 GPI anti-D1 titers, clarify whether antibody titer fluctuations predict thrombosis a large international cohort patients who were persistently positive for antiphospholipid (aPL) the APS ACTION Registry.Patients with available blood samples from at least 4 time points (at baseline [year 1] years 2-4...
Wastewater-based epidemiology has emerged as a complementary tool for the monitoring of COVID-19 pandemic waves and circulation viral variants. The selection, standardization, dynamics different SARS-CoV-2 RNA targets in wastewater requires further investigation. In present study, 106 samples were collected over 24-month period from treatment plant Sondrio, north Italy, analyzed presence through quantification ORF1b, N1, N3 gene via one-step real-time qPCR. general, three demonstrated...
Abstract Introduction Indirect immunofluorescence (IIF) employing ethanol-fixed neutrophils (ethN) is still the method of choice for assessing antineutrophil cytoplasmic antibodies (ANCA) in ANCA-associated vasculitides (AAV). However, conventional fluorescence microscopy subjective and prone to high variability. The objective this study was evaluate novel pattern recognition algorithms standardized automated interpretation ANCA patterns. Methods Seventy ANCA-positive samples (20...