A5010892844- Growth Hormone and Insulin-like Growth Factors
- Pituitary Gland Disorders and Treatments
- Coenzyme Q10 studies and effects
- Sperm and Testicular Function
- Hormonal and reproductive studies
- Adipose Tissue and Metabolism
- Hypothalamic control of reproductive hormones
- Ovarian function and disorders
- Thyroid Disorders and Treatments
- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Hormonal Regulation and Hypertension
- Heart Failure Treatment and Management
- Reproductive Biology and Fertility
- Birth, Development, and Health
- Liver Disease Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Sexual Differentiation and Disorders
- Lipid metabolism and disorders
- Muscle metabolism and nutrition
- Cancer, Hypoxia, and Metabolism
- Reproductive Health and Technologies
- Vitamin C and Antioxidants Research
- Diabetes and associated disorders
- Antioxidant Activity and Oxidative Stress
Università Cattolica del Sacro Cuore
2015-2024
Agostino Gemelli University Polyclinic
1985-2024
University of Bari Aldo Moro
2022-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2011-2023
IRCCS Ospedale San Raffaele
2022
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2022
University of the Sacred Heart
2016-2022
Fatebenefratelli Hospital
2001-2021
University of Naples Federico II
2020
San Salvatore Hospital
2017
Objective Isolated hypogonadotropic hypogonadism (IHH) is a rare disorder with pubertal delay, normal (normoosmic-IHH, nIHH) or defective sense of smell (Kallmann syndrome, KS). Other reproductive and non-reproductive anomalies might be present although information on their frequency are scanty, particularly according to the age presentation. Design Observational cohort study carried out between January 2008 June 2016 within national network academic general hospitals. Methods We performed...
Recently a bio-artificial liver (BAL) system has been developed at the Academic Medical Center (AMC) of Amsterdam to bridge patients with acute failure (ALF) orthotopic transplantation (OLT). After successful testing AMC-BAL in rodents and pigs ALF, phase I study ALF waiting for (OLT) was started Italy. We present safety outcome first 7 aged 21–56 years coma grade III or IV. The total treatment time ranged from 8 35 hours. Three received 2 treatments two different BAL's within three days....
Recent evidence supports the occurrence of multiple hormonal and metabolic deficiency syndrome (MHDS) in chronic heart failure (CHF). However, no large observational study has unequivocally demonstrated its impact on CHF progression outcome. The T.O.S.CA. (Trattamento Ormonale nello Scompenso CArdiaco; Hormone Treatment Heart Failure) Registry been specifically designed to test hypothesis that MHDS affects morbidity mortality patients.The is a prospective, multicentre, involving 19 Italian...
ABSTRACT Ischemia‐reperfusion injury, a clinical problem during cardiac surgery, involves worsened adenosine trisphosphate (ATP) generation and damage to the heart. We studied carbon monoxide (CO) pretreatment, proven valuable in rodents but not previously tested large animals, for its effects on pig hearts subjected cardiopulmonary bypass with cardioplegic arrest. Hearts of CO‐treated pigs showed significantly higher ATP phosphocreatine levels, less interstitial edema, apoptosis...
Abstract In 187 node‐negative breast cancers, the expression of laminin receptors and collagenase IV was directly related in 52% cases, independently pathological (tumor size histology) biological (estrogen proliferative activity) features. Moreover, presence did not appear to influence tumor activity, evaluated as 3 H‐thymidine labelling index. this case series, relapse‐free survival overall at 6 years were significantly affected by size, hormone receptor status activity. Conversely, high...
Eleven cases of primary pancreatic adenocarcinomas have been investigated histochemically, immunohistochemically and with electron‐microscopy. Endocrine‐paracrine (EP) cells were present in six these tumours. In one case numerous 5HT‐enterochromaffin (EC) the intestinal type a few somatostatin immunoreactive D found. Two contained insulin‐immunoreactive another displayed glucagon‐IR elements. remaining two argyrophilic present. These findings demonstrate that polypeptide hormone or amine...
The effect of acute and chronic administration sulpiride sulphate on serum prolactin levels in humans was studied. Six normal women four men received an i.m. injection 100 mg at 0800 h. A control group saline solution 0.9%. Blood samples were taken before 30, 60 120 minutes after the injection. Serum determined by a double antibody radioimmunoassay technique. Sulpiride induced all subjects quick marked increment with peak values 30 minutes. At remained high. In another experiment six post...
Oxidative stress is involved both in metabolic syndrome and male infertility. Hypogonadism also associated with increased risk for cardiovascular disease. To investigate the role of gonadal steroids systemic antioxidant regulation, we determined plasma CoenzymeQ(10) (CoQ(10)) total capacity (TAC) postsurgical hypopituitaric patients. Twenty-six patients aged 28-55 years were studied 6-12 months after surgery. CoQ(10) levels measured by high-performance liquid chromatography TAC spectroscopy...
Aim of the study was to evaluate treatment efficacy and safety a scaled-up version our porcine hepatocytes based BAL system in pigs with complete liver ischemia (LIS). Thirty-one underwent total devascularization (LIS) by termino-lateral porta-caval shunts sutures around bile duct, common hepatic gastroduodenal arteries their accessory branches. The hepato-duodenal ligament completely transected. Four experimental groups were studied: first control group (LIS Control, n = 10) received...
Neurothekeoma (NTK) and plexiform fibrohistiocytic tumor (PFHT) are dermal neoplasms that share many clinical histologic features whose histogenesis is equally disputed. We analyzed the morphologic immunohistochemical of 43 NTK 18 PFHT to evaluate a possible relationship between these tumors. On basis amount myxoid stroma, we divided into neurothekeoma (MyNTK) (8 cases), mixed (MiNTK) (15 cellular (CNTK) (20 cases). MyNTK MiNTK were well circumscribed lesions composed spindle cells. CNTK had...
Di Nicuolo G, D’Alessandro A, Andria B, Scuderi V, Scognamiglio M, Tammaro Mancini Cozzolino S, Florio E, Bracco Calise F, Chamuleau RAFM. Long-term absence of porcine endogenous retrovirus infection in chronically immunosuppressed patients after treatment with the cell–based Academic Medical Center bioartificial liver. Xenotransplantation 2010; 17: 431–439. © 2010 John Wiley & Sons A/S. Abstract: Background: Clinical use liver (BAL) support acute failure as bridging therapy for...
Many conditions associated with male infertility are inducers of oxidative stress, including varicocele. Antioxidants, such as coenzyme Q10, may be useful in this case. To evaluate the antioxidant capacity seminal plasma infertile men varicocele before and after an oral supplementation Q10 , 38 patients were recruited from a pilot clinical trial. A standard semen analysis was also performed at baseline 3 months exogenous 100 mg per die. Seminal measured using spectroscopic method. Coenzyme...
Irisin, a recently discovered myokine, has been considered prognostic factor in several cardiovascular diseases. Nevertheless, no data are available on the role of irisin patients with heart failure (HF), both preserved (HFpEF) or reduced (HFrEF) ejection fraction. We have therefore evaluated circulating levels HFpEF and HFrEF patients, correlating them metabolic parameters total antioxidant capacity (TAC), as index oxidative stress. Irisin was significantly higher than (7.72 ± 0.76 vs 2.77...