A5013200200- Regulation of Appetite and Obesity
- Growth Hormone and Insulin-like Growth Factors
- Hormonal and reproductive studies
- Adipose Tissue and Metabolism
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Diet and metabolism studies
- Sexual Differentiation and Disorders
- Sperm and Testicular Function
- Muscle metabolism and nutrition
- Pituitary Gland Disorders and Treatments
- Stress Responses and Cortisol
- Hypothalamic control of reproductive hormones
- Exercise and Physiological Responses
- Obstructive Sleep Apnea Research
- Hormonal Regulation and Hypertension
- Biochemical Analysis and Sensing Techniques
- Ovarian function and disorders
- Eating Disorders and Behaviors
- Muscle activation and electromyography studies
- Adrenal Hormones and Disorders
- Estrogen and related hormone effects
- Sports Performance and Training
- Ovarian cancer diagnosis and treatment
- Neuroscience of respiration and sleep
- LGBTQ Health, Identity, and Policy
University of Turin
2015-2024
Ospedale Humanitas Gradenigo
2021-2024
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2020
IRCCS Istituto Auxologico Italiano
2017
Istituti di Ricovero e Cura a Carattere Scientifico
2017
University of Portsmouth
2016
University of Zadar
2016
CHA Bundang Medical Center
2016
Seoul St. Mary's Hospital
2016
Hospital Central de la Cruz Roja San José y Santa Adela
2013
Summary objective Adiponectin is an adipocyte‐specific secretory protein which exhibits antiatherogenic, anti‐inflammatory and antidiabetic properties. We hypothesized that testosterone plays important role in the regulation of its secretion humans, as adiponectin concentrations are higher women than men administration accompanied by a reduction serum animals reduced cultured adipocytes. This study aimed to evaluate levels hypogonadal prior during replacement therapy. subjects methods In...
Objective Isolated hypogonadotropic hypogonadism (IHH) is a rare disorder with pubertal delay, normal (normoosmic-IHH, nIHH) or defective sense of smell (Kallmann syndrome, KS). Other reproductive and non-reproductive anomalies might be present although information on their frequency are scanty, particularly according to the age presentation. Design Observational cohort study carried out between January 2008 June 2016 within national network academic general hospitals. Methods We performed...
Context Chronic hypoxia induces complex metabolic and endocrine adaptations. High-altitude (HA) exposure is a physiological model of hypoxia. Objective To further investigate the responses to extreme HA. Methods We studied nine male elite climbers at sea level 5200 m after climbing Mt. Everest. Results After 7 weeks HA, body weight was reduced ( P <0.05); regarding variables we observed: a) an increase 2-h mean GH concentration <0.05) as well total IGF-I IGF binding protein-3 levels...
Summary objective Ghrelin, a gastric‐derived natural ligand of the GH secretagogue (GHS)‐receptor (GHS‐R), strongly stimulates secretion but also possesses other neuroendocrine actions, food intake and modulates endocrine pancreas energy homeostasis. Ghrelin is negatively modulated by intake. Similarly, glucose insulin probably exert an inhibitory effect on ghrelin secretion. Fasting levels are reduced in obesity, elevated anorexia nervosa restored weight recovery. The chronic elevation...
To determine the frequency of mutations gonadotropin-releasing hormone receptor (GnRHR) and G protein-coupled 54 (GPR54) genes in normosmic idiopathic hypogonadotropic hypogonadism (IHH).In a retrospective study we analyzed GnRHR GPR54 45 IHH patients 50 controls. Genomic DNA was amplified by PCR to obtain partially overlapping amplicons encompassing exon-intron boundaries single-stranded conformation polymorphism gel electrophoresis and/or sequencing.One heterozygous R262Q mutation gene...
Recent evidence suggests that ghrelin exerts a negative modulation on the gonadal axis. Ghrelin was reported to suppress LH secretion in both animal and human models. Moreover, acylated (AG) also decreases responsiveness GnRH vitro.The objective of study evaluate effects AG infusion spontaneous stimulated gonadotropin secretion.In seven young healthy male volunteers (age mean +/- sem 26.4 2.6 yr), we evaluated FSH levels every 15 min during: 1) iv isotonic saline infusion; 2) followed by AG;...
Abstract The short ACTH test is widely used in clinical practice for the diagnosis of adrenal insufficiency. It classically performed administering 250.0 μg ACTH(1–24) although 1.0 dose has been reported having maximal stimulatory effect on cortisol levels normal subjects. We aimed to define and minimal cortisol, aldosterone, dehydroepiandrosterone (DHEA) humans. To this goal, 12 volunteers (6 males 6 females; age, 22–34 yr; body mass index 20–25 kg/m2; surface 1.6–1.9 m2), we studied...
Summary objectives Obstructive sleep apnoea syndrome (OSAS) is strongly associated with obesity and characterized by endocrine metabolic changes including impairment of insulin sensitivity. The aim this study was to further clarify the dynamics glucose metabolism in condition. design, patients measurements We studied 30 obese OSAS [OSA, 21 males, 9 females; age, mean ± SEM: 53·1 1·7 years; body mass index (BMI): 38·6 1·1 kg/m 2 ; waist‐to‐hip ratio (WHR): 0·99 0·07; Apnoea/Hypopnoea Index...
Obstructive sleep apnea syndrome (OSAS) is a serious, prevalent condition that has significant morbidity and mortality when untreated. It strongly associated with obesity characterized by changes in the serum levels or secretory patterns of several hormones. Obese patients OSAS show reduction both spontaneous stimulated growth hormone (GH) secretion coupled to reduced insulin-like factor-I (IGF-I) concentrations impaired peripheral sensitivity GH. Hypoxemia chronic fragmentation could affect...
Turner's syndrome (TS) is a rare genetic disorder caused by complete or partial X chromosome monosomy in phenotypic female, and it associated with increased morbidity mortality for cardiovascular diseases, impaired glucose tolerance, dyslipidemia.In 30 adult TS patients under chronic hormonal replacement therapy (HRT), 17β-estradiol (E(2)), body mass index (BMI), waist circumference, fasting insulin, homeostatic model assessment (HOMA) index, serum lipids, oral tolerance test (OGTT), 24 h...
Abstract Background Risk factors established during adolescence affect health outcomes in adulthood, although little is known about how adolescent risk behaviours ( HRB s) testicular development and reproductive health. Objectives To assess prevalence of s among last year high school students; to describe the most prevalent andrological disorders this cohort; explore associated with investigate possibly impaired puberty. Materials methods The Amico‐Andrologo Survey a permanent nationwide...
To clarify the impairment of GH/IGF-I axis in obstructive sleep apnea syndrome (OSAS), 13 adult male patients with OSAS (OSA) as well 15 weight-matched simple obesity (OB) and 10 normal lean subjects (NS), we studied: 1) GH response to GHRH (1 μg/kg iv) plus arginine (30 g iv); 2) IGF-I IGF binding protein-3 responses a very low dose recombinant human (rh)GH treatment (5.0 sc per day for 4 d). The OSA was lower than OB (P < 0.05), which turn NS 0.001). Basal levels were 0.03). As opposed NS,...
From preliminary observations, GH-IGF-I seems to be compromised in men with aromatase deficiency. The GH deficiency (GHD) coexists paradoxically tall stature, raising the question whether or not a true GHD is part of this rare syndrome.To evaluate secretion aromatase-deficient men, their response GHRH plus arginine (GHRH-ARG) test was compared that normal subjects. effect estrogen replacement treatment on axis evaluated before and during therapy.A case-control study conducted.Four adult were...