A5009603528- Hormonal Regulation and Hypertension
- Regulation of Appetite and Obesity
- Adrenal and Paraganglionic Tumors
- Cancer, Hypoxia, and Metabolism
- Adipose Tissue and Metabolism
- Growth Hormone and Insulin-like Growth Factors
- Medical Imaging and Pathology Studies
- Pituitary Gland Disorders and Treatments
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Adrenal Hormones and Disorders
- Cancer, Lipids, and Metabolism
- Diabetes Treatment and Management
- Sulfur Compounds in Biology
- Pancreatic function and diabetes
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- MRI in cancer diagnosis
- Eicosanoids and Hypertension Pharmacology
- Adipokines, Inflammation, and Metabolic Diseases
- Biochemical Analysis and Sensing Techniques
- Apelin-related biomedical research
- High Altitude and Hypoxia
- Renal cell carcinoma treatment
Diabetes Australia
2020
University of Turin
2006-2019
University of Padua
2013-2016
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2013-2016
Aarhus University
2013
University of Pisa
2013
University of Regensburg
2013
Aldosterone-producing adenomas (APAs) cause a sporadic form of primary aldosteronism and somatic mutations in the KCNJ5 gene, which encodes G-protein–activated inward rectifier K + channel 4, GIRK4, account for ≈40% APAs. Additional APA were identified recently 2 other genes, ATP1A1 ATP2B3 , encoding Na /K -ATPase 1 Ca 2+ 3, respectively, at combined prevalence 6.8%. We have screened 112 APAs known hotspots genetic alterations associated with aldosteronism. Somatic present 6.3%, 0.9%, 39.3%...
Context Chronic hypoxia induces complex metabolic and endocrine adaptations. High-altitude (HA) exposure is a physiological model of hypoxia. Objective To further investigate the responses to extreme HA. Methods We studied nine male elite climbers at sea level 5200 m after climbing Mt. Everest. Results After 7 weeks HA, body weight was reduced ( P <0.05); regarding variables we observed: a) an increase 2-h mean GH concentration <0.05) as well total IGF-I IGF binding protein-3 levels...
Objectives: To assess the prevalence of primary aldosteronism and its association with cardiometabolic complications in patients resistant refractory hypertension. Methods: One hundred ten consecutive true hypertension [insufficient blood pressure control despite appropriate lifestyle measures treatment at least three classes antihypertensive medication, including a diuretic] without previous cardiovascular events were screened for secondary Refractory was diagnosed case uncontrolled use...
Adrenal vein sampling (AVS) is the only reliable means to distinguish between aldosterone-producing adenoma and bilateral adrenal hyperplasia, two most common subtypes of primary aldosteronism (PA). AVS protocols are not standardized vary widely centers.The objective study was retrospectively investigate whether presence contralateral (CL) suppression aldosterone secretion associated with improved postoperative outcomes in patients who underwent unilateral adrenalectomy for PA.The carried...
Von Hippel-Lindau disease (VHLD) is a rare inherited neoplastic syndrome. Among all the VHLD-associated tumors, clear cell renal carcinoma (ccRCC) major cause of death.The aim this paper discovery new non-invasive biomarker for monitoring VHLD patients.We compared urinary proteome patients, ccRCC patients and healthy volunteers.Among differentially expressed proteins, alpha-1-antitrypsin (A1AT) APOH (beta-2-glycoprotein-1) are strongly over-abundant only in urine with history ccRCC.A1AT...
In most cases of primary aldosteronism (PA), An adrenal aldosterone-secreting tumor cannot be reasonably proven, so these patients undergo medical treatment. Controversial data exist about the evolution PA after therapy: long-term treatment with mineralocorticoid antagonists has been reported to normalize aldosterone levels but other authors failed find remission hypersecretion. Thus, we planned retest secretion in medically treated diagnosed at least 3 years before.Retrospective,...
Acylated ghrelin (AG) is a physiological GH secretion amplifier, in part stimulating GHRH neurones and antagonizing somatostatin activity. In humans, AG one of the most potent pharmacological stimuli and, unlike GHRH, refractory to inhibitory effect glucose, free fatty acids (FFA) somatostatin. Somatotroph also profoundly modulated by adrenergic system. Indeed, beta-adrenergic agonists abolish spontaneous GHRH-stimulated secretion. Based on these data, aim present study was investigate...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Sommario La sindrome di von Hippel-Lindau è una patologia ereditaria multisistemica che predispone allo sviluppo neoplasie frequentemente natura endocrina. I tumori neuroendocrini pancreatici, i feocromocitomi e paragangliomi rappresentano le principali manifestazioni endocrine della sindrome. Tali presentano caratteristiche peculiari, seppur non patognomoniche, possono essere utili nell’orientamento diagnostico. L’endocrinologo rappresenta quindi figura fondamentale del gruppo...
Objective: Pheochromocytomas and paragangliomas (PPGLs) are rare neoplasms often releasing cathecolamines, mainly originating from adrenals but occasionally observed in sympathetic parasympathetic ganglia, with a genetic base up to 25% of the cases. After radical surgery these tumors, disease recurrence was believed be under 10% recent studies reported higher rate even after many years. Apart familiar forms, little evidence exist about predictors relapse, so we aimed research retrospective...
Objective: Idiopatic hyperaldosteronism (IHA) due to bilateral production of aldosterone (bilateral PA) is the most common subtype primary aldosteronism (PA). Adrenal CT scanning in PA patients can show normal diffuse enlargement or nodular glands. Natural course adrenal mass lesions IHA has not yet been fully clarified. The aim our study was assess over time evolution CT-detectable nodule(s) with IHA. Design and method: Thirty-two diagnosed as during last 6 years were recruited on basis...