A5013814011- COVID-19 Clinical Research Studies
- Cancer, Hypoxia, and Metabolism
- COVID-19 Impact on Reproduction
- Vitamin D Research Studies
- Diet and metabolism studies
- Metabolism and Genetic Disorders
- Urticaria and Related Conditions
- Inflammatory Myopathies and Dermatomyositis
- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Drug-Induced Adverse Reactions
- Congenital Heart Disease Studies
- Pulmonary Hypertension Research and Treatments
- Family and Disability Support Research
- Congenital Diaphragmatic Hernia Studies
- Congenital Anomalies and Fetal Surgery
- Pediatric Hepatobiliary Diseases and Treatments
King's College Hospital
2023
Birmingham Women’s and Children’s NHS Foundation Trust
2021
Calvary Riverina Hospital
2021
Sandwell & West Birmingham Hospitals NHS Trust
2019
Brain Tumour Research
2016-2017
University of Nottingham
2016-2017
Abstract Coronavirus disease 2019 (COVID-19) has caused mild illness in children, until the emergence of novel hyperinflammatory condition paediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory coronavirus 2 (SARS-CoV-2) (PIMS-TS). PIMS-TS is thought to be a post-SARS-CoV-2 immune dysregulation excessive cytokine release. We studied 25 hydroxyvitamin D (25OHD) concentrations children PIMS-TS, admitted tertiary hospital UK, due its postulated role...
Introduction Pulmonary hypertension in infants is characterized by elevated pulmonary vascular resistance which leads to right-to-left shunting of deoxygenated blood across the ductus arteriosus and foramen ovale into systemic circulation leading hypoxemia. It associated with significant morbidity mortality rate has been reported be between 7 15%, increased particularly congenital diaphragmatic hernia (CDH) or bronchopulmonary dysplasia (BPD).
<h3>Background</h3> Coronavirus disease 2019 (COVID-19), has caused mild illness in children, until the emergence of novel hyperinflammatory condition PIMS-TS: Paediatric Inflammatory Multisystem Syndrome Temporally associated with Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). PIMS-TS is thought to be a post- SARS-CoV-2 immune dysregulation excessive inflammatory cytokine release. <h3>Objectives</h3> There been long-standing interest role 25 hydroxyvitamin D (25OHD)...
Abstract Introduction Myositis is a broad diagnosis with number of potential causes. There are numerous drugs that can lead to myotoxicity. We discuss case patient known rheumatoid arthritis who developed myositis no evidence an additional autoimmune condition and where the most likely cause seems be leflunomide. Case description A 46-year-old Asian lady background seropositive overactive bladder increasing muscle weakness. Disease activity was well-controlled on leflunomide which had been...
EPN-09. KETOLYTIC AND GLYCOLYTIC ENZYMATIC EXPRESSION IN PAEDIATRIC EPENDYMOMAS: IMPLICATION FOR KETOGENIC DIET THERAPY Lisa C.D. Storer1, Angeline Darren1, Simon M.L. Paine2, Jen Kearns3, Robert Layfield4, David A. Walker1, and Richard G. Grundy1; Children’s Brain Tumour Research Centre, School of Medicine, University Nottingham, UK; Department Neuropathology, Nottingham Hospitals NHS Trust, Division Nutritional Sciences, Life UK Ependymoma is the second most common paediatric malignant...
<h3></h3> Children with liver disease, and those who undergo transplantation, are at significant risk of developmental deficits across all areas; motor, cognitive, language behaviour. Early childhood adversity may have an impact on the developing brain lasting consequences throughout into adulthood. With improved survival rates following transplantation in paediatric population emphasis is children 'not only surviving but thriving', focus quality life, functional abilities social/emotional...
Ependymoma is the second most common paediatric malignant brain tumour. Overall survival remains relatively poor, and at relapse dismal. One potential strategy to improve outcome exploiting metabolic differences between normal tumour cells. Under physiological conditions, cells metabolise glucose for energy. If ‘starved’ of glucose, ketone bodies are metabolised. Mitochondrial defects in obviate this flexibility resulting a dependence on glycolytic energy (Warburg effect). Thus, high fat,...
<h3>Background</h3> Clinical characterisation studies of children with laboratory confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have enabled better understanding paediatric disease 2019 (COVID-19). However, to our knowledge, there been no evaluating the predictive value clinical symptoms for COVID-19. This gap in evidence is significant as frontline healthcare settings use determine control policy and patient cohorting measures. Despite showing that a mild...