A5078264407- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- T-cell and B-cell Immunology
- COVID-19 epidemiological studies
- Complement system in diseases
- Sepsis Diagnosis and Treatment
- Kawasaki Disease and Coronary Complications
- COVID-19 Impact on Reproduction
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Adrenal Hormones and Disorders
- Down syndrome and intellectual disability research
- Reproductive System and Pregnancy
- Lipid metabolism and disorders
- Clusterin in disease pathology
- Lymphoma Diagnosis and Treatment
- Family and Disability Support Research
- Immune Response and Inflammation
- Cytomegalovirus and herpesvirus research
- T-cell and Retrovirus Studies
- Influenza Virus Research Studies
- Alzheimer's disease research and treatments
- Cutaneous lymphoproliferative disorders research
- Diabetes Management and Research
- Pregnancy and preeclampsia studies
Cardiff University
2021-2024
UK Dementia Research Institute
2022
Institute of Infection and Immunity
2021
Multisystem inflammatory syndrome in children (MIS-C) is a life-threatening disease occurring several weeks after severe acute respiratory coronavirus 2 (SARS-CoV-2) infection. Deep immune profiling showed MIS-C patients had highly activated neutrophils, classical monocytes and memory CD8+ T-cells, with increased frequencies of B-cell plasmablasts double-negative B-cells. Post treatment samples from the same patients, taken during symptom resolution, identified recovery-associated features...
Abstract Sepsis is a heterogeneous condition defined as life-threatening organ dysfunction caused by dysregulated host response to infection. For some, sepsis presents predominantly suppressive disorder, whilst others experience pro-inflammatory which can culminate in ‘cytokine storm’. Frequently, patients signs of concurrent hyper-inflammation and immunosuppression, underpinning the difficulty directing effective treatment. Although intensive care unit mortality rates have improved recent...
Complement, a critical defence against pathogens, has been implicated as driver of pathology in COVID-19. Complement activation products are detected plasma and tissues complement blockade is considered for therapy. To delineate roles immunopathogenesis, we undertook the largest comprehensive study COVID-19 to date, profiling 16 biomarkers, including key components, regulators products, 966 samples from 682 hospitalized patients collected across hospitalization period part UK ISARIC4C...
Abstract Accurate assessment of SARS‐CoV‐2 immunity is critical in evaluating vaccine efficacy and devising public health policies. Whilst the exact nature effective remains incompletely defined, SARS‐CoV‐2‐specific T‐cell responses are a feature that will likely form key correlate protection against COVID‐19. Here, we developed optimized high‐throughput whole blood‐based assay to determine response associated with prior infection and/or vaccination amongst 231 healthy donors 68 cancer...
Down syndrome (DS) is associated with immune dysregulation and a high risk of early onset Alzheimer's disease (AD). Complement key part innate immunity driver pathological inflammation, including neuroinflammation in AD. has been reported DS; however, the pattern its relationship to AD unclear.
Abstract Severe bacterial or viral infections can induce a state of immune hyperactivation that culminate in potentially lethal cytokine storm. The classic example is toxic shock syndrome, life-threatening complication Staphylococcus aureus Streptococcus pyogenes infection, which driven by potent toxins known as superantigens (SAgs). SAgs are thought to promote evasion via the promiscuous activation T cells, subsequently become hyporesponsive, and act cross-linking major histocompatibility...
Inflammation plays a fundamental role in the development of several metabolic diseases, including obesity and type 2 diabetes (T2D); complement system has been implicated their development. People Black African (BA) ethnicity are disproportionately affected by T2D other diseases but impact on not explored. We investigated ethnic differences biomarkers activation status between men BA White European (WE) explored association with parameters health. measured panel 15 components, regulators,...
ABSTRACT Natural killer (NK) cells are specialized lymphocytes that help protect against viruses and cancer. However, in the context of bacterial infections, NK can be harmful, rather than protective. Such immune pathogenesis by has been linked to over-production pro-inflammatory cytokines like interferon-γ (IFN-γ). In this context, IFN-γ-deficient mice display increased survival rates response Staphylococcus aureus ( S. ), which causes life-threatening, invasive systemic infections with...
Abstract Accurate assessment of SARS-CoV-2 immunity in the population is critical to evaluating vaccine efficacy and devising public health policies. Whilst exact nature effective remains incompletely defined, SARS-CoV-2-specific T cell responses are a feature immune response that will likely form key correlate protection against COVID-19. Here, we developed optimised high-throughput whole blood-based assay determine associated with prior infection and/or vaccination amongst 156 healthy...
Maternal sepsis remains a leading cause of death in pregnancy. Physiological adaptations to pregnancy obscure early signs and can result delays recognition treatment. Identifying biomarkers that reliably diagnose will reduce morbidity mortality antibiotic overuse. We have previously identified an immune-metabolic biomarker network comprising three pathways with >99% accuracy for detecting bacterial neonatal sepsis. In this prospective study, we describe physiological parameters novel two...
Multisystem inflammatory syndrome in children (MIS-C) is a life-threatening disease occurring several weeks after severe acute respiratory coronavirus 2 (SARS-CoV-2) infection. Deep immune profiling showed MIS-C patients had highly activated neutrophils, classical monocytes and memory CD8+ T-cells; increased frequencies of B-cell plasmablasts double-negative B-cells. Post treatment samples from the same patients, taken when symptoms were resolving, identified recovery-associated features...