A5007694269- SARS-CoV-2 and COVID-19 Research
- Sleep and Wakefulness Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Birth, Development, and Health
- Lysosomal Storage Disorders Research
- Vaccine Coverage and Hesitancy
- Retinal Diseases and Treatments
- Medical Imaging and Pathology Studies
- Gastrointestinal disorders and treatments
- COVID-19 Clinical Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Gastrointestinal Tumor Research and Treatment
- Glycogen Storage Diseases and Myoclonus
- Ginkgo biloba and Cashew Applications
- Sleep and related disorders
- COVID-19 diagnosis using AI
- Long-Term Effects of COVID-19
- Neurobiology of Language and Bilingualism
- Cardiovascular Function and Risk Factors
- Lung Cancer Diagnosis and Treatment
- Diabetes Management and Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Stuttering Research and Treatment
- Memory and Neural Mechanisms
- Influenza Virus Research Studies
University of Bristol
2020-2024
University of Central Florida
2024
North Bristol NHS Trust
2021-2023
Southmead Hospital
2022
At Bristol
2019
Guy's and St Thomas' NHS Foundation Trust
2016
GlaxoSmithKline (United States)
2015
Kings County Hospital Center
2002-2003
SUNY Downstate Health Sciences University
2003
Addenbrooke's Hospital
2003
We previously reported a syndrome of severe hyperinsulinemia and early-onset hypertension in three patients with dominant-negative mutations the nuclear hormone receptor peroxisome proliferator-activated (PPAR)-γ. now report results further detailed pathophysiological evaluation these subjects, identification affected prepubertal children within one original families, effects thiazolidinedione therapy two subjects. These studies 1) definitively demonstrate presence peripheral hepatic insulin...
Millions of people worldwide take medications such as L-DOPA that increase dopamine to treat Parkinson's disease. Yet, we do not fully understand how affects sleep and memory. Our earlier research in disease revealed the timing relative dopamine's impact on long-term Dopamine projections between midbrain hippocampus potentially support memory processes during slow wave sleep. In this study, aimed test hypothesis enhances consolidation by modulating NREM
Background: CLN2 disease, a rare, inherited, pediatric-onset, neurodegenerative lysosomal storage disorder caused by TPP1 enzyme deficiency, is characterized seizures, ataxia, rapid loss of language and motor functions, blindness, early death. Cerliponase alfa (BMN 190) recombinant human enzyme. This phase 1/2, multicenter, open-label, dose-escalation study evaluated the safety, tolerability, efficacy every other week intracerebroventricular (ICV) infusions cerliponase in children with aged...
Stuttering is a complex speech disorder that associated with variety of etiologies, including psychological factors, metabolic disorders, and structural abnormalities. While stuttering typically not caused by stroke, it important to include in the diagnostic evaluation, especially patients history neurological conditions. Of clinical presentations stroke-induced stuttering, transient following stroke has seldom been documented, as most who develop stutter end up developing permanent...
Abstract The human brain selectively stores knowledge of the world to optimise future behaviour, automatically rehearsing, contextualising or discarding information create a robust record experiences. Storage forgetting evolves over time, particularly during sleep. We have previously shown that dopamine given in form L-DOPA tablets improves long-term memory Parkinson’s disease, but only when overnight. is already prescribed widely with good safety profile and could potentially be rapidly...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
ABSTRACT Introduction Radiological change which may be attributed to infection can also attributable lung cancer. Patients with SARS-CoV-2 develop groundglass opacification result in chronic changes. Current British Thoracic Society (BTS) guidelines recommend patients pneumonia and COVID19 undergo repeat chest radiography. Methods A single-centre audit of hospitalised community-acquired or over three time periods during the pandemic (Aug-Dec 2020, Jun-Aug 2021, Dec-Jan 2022). We assessed...
ABSTRACT Introduction Hospitalisations relating to acute respiratory deteriorations (ARD) in Interstitial Lung Disease (ILD) have poor outcomes. Factors predicting adverse outcomes are not fully understood and data addressing the use of illness severity scores prognostication limited. Objective To investigate CURB-65 NEWS-2 prediction mortality following ARD-ILD hospitalisation, using prospective methodology validate previously determined cut-offs, derived from a retrospective study cohort....
It presents much of the evidence relating adult mortality and metabolism to early fetal infant development.The story begins with descriptions spatial temporal associa- tions made largely on basis routinely collected statistics from United Kingdom Norway.As all such studies their results were inconclusive but raise a host important questions.The methodological "breakthrough", as is well known