Xinxue Liu
A5047931301- SARS-CoV-2 and COVID-19 Research
- Esophageal Cancer Research and Treatment
- Vaccine Coverage and Hesitancy
- Salmonella and Campylobacter epidemiology
- Viral gastroenteritis research and epidemiology
- Vibrio bacteria research studies
- Gastric Cancer Management and Outcomes
- Bacterial Infections and Vaccines
- COVID-19 Clinical Research Studies
- Esophageal and GI Pathology
- Cancer-related gene regulation
- Child Nutrition and Water Access
- Immunotherapy and Immune Responses
- Ovarian cancer diagnosis and treatment
- Pneumonia and Respiratory Infections
- Gastroesophageal reflux and treatments
- Infant Nutrition and Health
- Lung Cancer Diagnosis and Treatment
- Respiratory viral infections research
- Helicobacter pylori-related gastroenterology studies
- PARP inhibition in cancer therapy
- Clinical Nutrition and Gastroenterology
- Hepatitis Viruses Studies and Epidemiology
- Venous Thromboembolism Diagnosis and Management
- Influenza Virus Research Studies
University of Oxford
2018-2025
Oxford BioMedica (United Kingdom)
2019-2025
Beijing Institute of Fashion Technology
2024
Creative Commons
2023
Imperial College London
2015-2023
Imperial College Healthcare NHS Trust
2023
University College London
2023
University College Hospital
2023
Guy's and St Thomas' NHS Foundation Trust
2023
King's College London
2023
The inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac, Sinovac) has been widely used in a two-dose schedule. We assessed whether third dose of the homologous or different could boost immune responses.
Venous disease is the most common cause of leg ulceration. Although compression therapy improves venous ulcer healing, it does not treat underlying causes hypertension. Treatment superficial reflux has been shown to reduce rate recurrence, but effect early endovenous ablation on healing remains unclear.
Salmonella Typhi is a major cause of fever in children low- and middle-income countries. A typhoid conjugate vaccine (TCV) that was recently prequalified by the World Health Organization shown to be efficacious human challenge model, but data from efficacy trials areas where endemic are lacking.
Some high-income countries have deployed fourth doses of COVID-19 vaccines, but the clinical need, effectiveness, timing, and dose a remain uncertain. We aimed to investigate safety, reactogenicity, immunogenicity fourth-dose boosters against COVID-19.
BackgroundTyphoid fever remains a major cause of morbidity and mortality in low-income middle-income countries. Vi-tetanus toxoid conjugate vaccine (Vi-TT) is recommended by WHO for implementation high-burden countries, but there little evidence about its ability to protect against clinical typhoid such settings.MethodsWe did participant-masked observer-masked cluster-randomised trial preceded safety pilot phase an urban endemic setting Dhaka, Bangladesh. 150 clusters, each with...
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine immunogenicity varies between individuals, and immune responses correlate with efficacy. Using data from 1,076 participants enrolled in ChAdOx1 nCov-19 efficacy trials the United Kingdom, we found that inter-individual variation normalized antibody against SARS-CoV-2 spike its receptor-binding domain (RBD) at 28 days after first vaccination shows genome-wide significant association major histocompatibility complex...
The current study evaluated three biomarkers [homologous recombination deficiency (HRD), tumor BRCA1/2 (tBRCA) mutations, and CCNE1 copy-number variation (CNV)] in ovarian tumors from patients enrolled on the SCOTROC4 clinical trial for associations with outcome following carboplatin monotherapy. Ovarian (n = 250), high-grade serous (HGSOC) subgroup analysis 179) were classified as HRD positive (HRD score ≥42 or tBRCA mutation) amplification (CCNE1 CNV >2.4). Seventy-four (30%) positive,...
Parenteral nutrition is central to the care of very immature infants. Current international recommendations favor higher amino acid intakes and fish oil-containing lipid emulsions.The aim this trial was compare 1) effects high [immediate recommended daily intake (Imm-RDI)] low [incremental introduction acids (Inc-AAs)] parenteral delivery within 24 h birth on body composition 2) effect a multicomponent emulsion containing 30% soybean oil, medium-chain triglycerides, 25% olive 15% oil (SMOF)...
Typhoid fever is a major public health problem in low-resource settings. Vaccination can help curb the disease and might reduce transmission. We have previously reported an interim analysis of efficacy typhoid conjugate vaccine (TCV) Nepali children. Here we report final results after 2 years follow-up.We did participant-masked observer-masked individually randomised trial Lalitpur, Nepal, which 20 019 children aged 9 months to younger than 16 were randomly assigned 1:1 ratio receive single...
Abstract Background The longitudinal antigen-specific immunity in COVID-19 convalescents is crucial for long-term protection upon individual re-exposure to SARS-CoV-2, and even more pivotal ultimately achieving population-level immunity. We conducted this cohort study better understand the features of immune memory individuals with different disease severities at 1 year post–disease onset. Methods a systematic evaluation 101 convalescents, who had asymptomatic, mild, moderate, or severe...
To evaluate the persistence of immunogenicity three months after third dose boosters.
Esophageal adenocarcinoma (EAC) is a highly aggressive disease with poor long-term survival. Despite growing knowledge of its biology, no molecular biomarkers are currently used in routine clinical practice to determine prognosis or aid decision making. Hence, this study set out identify and validate small, clinically applicable immunohistochemistry (IHC) panel for prognostication patients EAC.We recently identified eight prognostic using two different genomic platforms. IHC scores these...
Abstract In this report, we present live neutralisation titres against SARS-CoV-2 Omicron variant, compared with Victoria, Beta and Delta variants. Sera from day-28 post second-dose were obtained participants in the Com-COV2 study who had received a two-dose COVID-19 vaccination schedule either AstraZeneca (AZD1222) or Pfizer (BNT162b2) vaccines. There was substantial fall recipients of both AZD1222 BNT16b2 primary courses, evidence some failing to neutralise at all. This will likely lead...
BackgroundVaccination of children and young people against SARS-CoV-2 is recommended in some countries. Scarce data have been published on immune responses induced by COVID-19 vaccines younger than 18 years compared with the same that are available adults.MethodsCOV006 a phase 2, single-blind, randomised, controlled trial ChAdOx1 nCoV-19 (AZD1222) adolescents at four sites UK. Healthy participants aged 6–17 years, who did not history chronic respiratory conditions, laboratory-confirmed...
Abstract Background Conventional systemic drugs are used to treat children and young people (CYP) with severe atopic dermatitis (AD) worldwide, but no robust randomized controlled trial (RCT) evidence exists regarding their efficacy safety in this population. While novel therapies have expanded therapeutic options, high cost means traditional agents remain important, especially lower-resource settings. Objectives To compare the of ciclosporin (CyA) methotrexate (MTX) CYP AD TREatment Atopic...