Weifeng Shi
A5079289072- Influenza Virus Research Studies
- Viral Infections and Vectors
- Animal Disease Management and Epidemiology
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- Viral Infections and Immunology Research
- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Mosquito-borne diseases and control
- Viral Infections and Outbreaks Research
- Plant Virus Research Studies
- interferon and immune responses
- Advanced Algorithms and Applications
- RNA and protein synthesis mechanisms
- Cytomegalovirus and herpesvirus research
- Advanced Sensor and Control Systems
- Peer-to-Peer Network Technologies
- Cancer-related molecular mechanisms research
- COVID-19 Clinical Research Studies
- Virus-based gene therapy research
- Insect symbiosis and bacterial influences
- Bacteriophages and microbial interactions
- Vector-Borne Animal Diseases
- Advanced Computational Techniques and Applications
- Genomics and Phylogenetic Studies
Soochow University
2013-2025
Ruijin Hospital
2022-2025
Shanghai Jiao Tong University
2017-2025
Nestlé (Germany)
2025
Shandong First Medical University
2019-2024
Shanghai Maritime University
2012-2024
China Academy of Railway Sciences
2024
Institute of Computing Technology
2024
Chinese Academy of Sciences
2011-2024
Czech Academy of Sciences, Institute of Microbiology
2019-2024
In December 2019, a cluster of patients with pneumonia unknown cause was linked to seafood wholesale market in Wuhan, China. A previously betacoronavirus discovered through the use unbiased sequencing samples from pneumonia. Human airway epithelial cells were used isolate novel coronavirus, named 2019-nCoV, which formed clade within subgenus sarbecovirus, Orthocoronavirinae subfamily. Different both MERS-CoV and SARS-CoV, 2019-nCoV is seventh member family coronaviruses that infect humans....
Cross-species transmission of viruses from wildlife animal reservoirs poses a marked threat to human and health
Mutation for microcephaly Zika virus infections in humans have been known since 1947. Microcephaly and neuropathologies associated with only reported recently, most prevalently the Americas. Yuan et al. investigated recent stable mutations genome engineered them into a low-virulence ancestral strain (see Perspective by Screaton Mongkolsapaya). A single amino acid substitution (serine to asparagine, S139N) viral precursor membrane protein exacerbated symptoms pregnant mice. The reverse...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of recent pandemic COVID-19, is reported to have originated from bats, with its intermediate host unknown date. Here, we screened 26 animal counterparts human ACE2 (hACE2), receptor for SARS-CoV-2 and SARS-CoV, found that ACE2s various species, including pets, domestic animals multiple wild animals, could bind binding domain (RBD) facilitate transduction pseudovirus. Comparing SARS-CoV-2, SARS-CoV seems a...
A novel Ebola virus (EBOV) first identified in March 2014 has infected more than 25,000 people West Africa, resulting 10,000 deaths. Preliminary analyses of genome sequences 81 EBOV collected from to June Guinea and Sierra Leone suggest that the originated an independent transmission event its natural reservoir followed by sustained human-to-human infections. It been reported variation might have effect on efficacy sequence-based detection candidate therapeutics. However, only limited viral...
Abstract Background Explicit evolutionary models are required in maximum-likelihood and Bayesian inference, the two methods that overwhelmingly used phylogenetic studies of DNA sequence data. Appropriate selection nucleotide substitution is important because use incorrect can mislead inference. To better understand performance different model-selection criteria, we 33,600 simulated data sets to analyse accuracy, precision, dissimilarity, biases hierarchical likelihood-ratio test, Akaike...
Abstract We have surveyed avian influenza virus (AIV) genomes from live poultry markets within China since 2014. Here we present a total of 16,091 samples that were collected May 2016 to February 2019 in 23 provinces and municipalities China. identify 2048 AIV-positive perform next generation sequencing. rates (12.73%) had decreased substantially 2016, compared during 2014–2016 (26.90%). Additionally, H9N2 has replaced H5N6 H7N9 as the dominant AIV subtype both chickens ducks. Notably, novel...
ABSTRACT Since its emergence in 2013, the H7N9 low-pathogenic avian influenza virus (LPAIV) has been circulating domestic poultry China, causing five waves of human infections. A novel highly pathogenic (HPAIV) variant possessing multiple basic amino acids at cleavage site hemagglutinin (HA) protein was first reported two cases infection January 2017. More seriously, those HPAIV variants have transmitted and caused outbreaks on farms eight provinces China. Herein, we demonstrate presence...
The Middle East respiratory syndrome coronavirus (MERS-CoV) causes a severe acute tract infection with high fatality rate in humans. Coronaviruses are capable of infecting multiple species and can evolve rapidly through recombination events. Here, we report the complete genomic sequence analysis MERS-CoV strain imported to China from South Korea. virus, provisionally named ChinaGD01, belongs group 3 clade B whole-genome phylogenetic tree also has similar topology structure open reading frame...
Eight avian influenza A (H5N6) viruses were isolated from live poultry markets (LPMs) in Sichuan and Jiangxi Provinces China 2014, including those close to the county where human H5N6 infection occurred. Genetic phylogenetic analyses revealed that these novel reassortants between H5N1 clade 2.3.4 H6N6 viruses, had evolved into two distinct lineages (Sichuan Jiangxi). Moreover, virus was closely related avian-source of lineage. Notably, contained a T160A substitution haemagglutinin protein an...