A5006025566- SARS-CoV-2 and COVID-19 Research
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- COVID-19 Clinical Research Studies
- Genomics and Phylogenetic Studies
- Mechanical Behavior of Composites
- RNA Research and Splicing
- Retinal Development and Disorders
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Genomic variations and chromosomal abnormalities
- Antibiotic Resistance in Bacteria
- Immunotherapy and Immune Responses
- Single-cell and spatial transcriptomics
- Ovarian cancer diagnosis and treatment
- Bioinformatics and Genomic Networks
- Parasitic Infections and Diagnostics
- Neuroinflammation and Neurodegeneration Mechanisms
- Animal Virus Infections Studies
- Molecular Biology Techniques and Applications
- Retinal Diseases and Treatments
- Viral gastroenteritis research and epidemiology
- Genetic Mapping and Diversity in Plants and Animals
- Spam and Phishing Detection
University of Chinese Academy of Sciences
2013-2025
The University of Texas MD Anderson Cancer Center
2016-2025
Beihang University
1998-2025
Chinese Academy of Sciences
2016-2025
Nanjing University of Chinese Medicine
2024-2025
Beijing Institute of Genomics
2018-2025
Harbin Medical University
2025
Third Affiliated Hospital of Harbin Medical University
2025
Second Hospital of Shandong University
2018-2025
Sichuan Agricultural University
2021-2025
Preclinical mouse models suggest that the gut microbiome modulates tumor response to checkpoint blockade immunotherapy; however, this has not been well-characterized in human cancer patients. Here we examined oral and of melanoma patients undergoing anti-programmed cell death 1 protein (PD-1) immunotherapy (
Spatially resolved transcriptomic technologies are promising tools to study complex biological processes such as mammalian embryogenesis. However, the imbalance between resolution, gene capture, and field of view current methodologies precludes their systematic application analyze relatively large three-dimensional mid- late-gestation embryos. Here, we combined DNA nanoball (DNB)-patterned arrays in situ RNA capture create spatial enhanced resolution omics-sequencing (Stereo-seq). We applied...
Abstract SARS-CoV-2, a β-coronavirus, has rapidly spread across the world, highlighting its high transmissibility, but underlying morphogenesis and pathogenesis remain poorly understood. Here, we characterize replication dynamics, cell tropism of SARS-CoV-2 in organotypic human airway epithelial (HAE) cultures. replicates efficiently infects both ciliated secretory cells HAE In comparison, HCoV-NL63 to lower titers is only detected cells. shows similar morphogenetic process as other...
We report co-infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza A virus in a patient pneumonia China. The case highlights possible co-detection of known viruses. noted low sensitivity upper specimens for SARS-CoV-2, which could further complicate recognition the full extent disease.
Abstract Background Since December 2019, an outbreak of the Corona Virus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) in Wuhan, China, has become a public health emergency international concern. The high fatality aged cases SARS‐CoV‐2 was need to explore possible age‐related phenomena with non‐human primate models. Methods Three 3‐5 years old and two 15 rhesus macaques were intratracheally infected SARS‐CoV‐2, then analyzed clinical signs,...
The National Genomics Data Center (NGDC) provides a suite of database resources to support worldwide research activities in both academia and industry. With the rapid advancements higher-throughput lower-cost sequencing technologies accordingly huge volume multi-omics data generated at exponential scales rates, NGDC is continually expanding, updating enriching its core through big integration value-added curation. In past year, efforts for update have been mainly devoted BioProject,...
Long non-coding RNAs (lncRNAs) have significant functions in a wide range of important biological processes. Although the number known human lncRNAs has dramatically increased, they are poorly annotated, posing great challenges for better understanding their functional significance and elucidating complex functioning molecular mechanisms. Here, we present LncBook (http://bigd.big.ac.cn/lncbook), curated knowledgebase that features comprehensive collection systematic curation by multi-omics...
Abstract The National Genomics Data Center (NGDC), part of the China for Bioinformation (CNCB), provides a suite database resources to support worldwide research activities in both academia and industry. With explosive growth multi-omics data, CNCB-NGDC is continually expanding, updating enriching its core through big data deposition, integration translation. In past year, considerable efforts have been devoted 2019nCoVR, newly established resource providing global landscape SARS-CoV-2...
Abstract The National Genomics Data Center (NGDC), which is a part of the China for Bioinformation (CNCB), provides family database resources to support global academic and industrial communities. With rapid accumulation multi-omics data at an unprecedented pace, CNCB-NGDC continuously expands updates core through big archiving, integrative analysis value-added curation. Importantly, NGDC collaborates closely with major international databases initiatives ensure seamless exchange...
Although inoculation of COVID-19 vaccines has rolled out globally, there is still a critical need for safe and effective to ensure fair equitable supply all countries. Here, we report on the development highly efficacious mRNA vaccine, SW0123 that composed sequence-modified encoding full-length SARS-CoV-2 Spike protein packaged in core-shell structured lipopolyplex (LPP) nanoparticles. easy produce using large-scale microfluidics-based apparatus. The unique nanoparticle facilitates vaccine...
Elucidating the cellular organization of cerebral cortex is critical for understanding brain structure and function. Using large-scale single-nucleus RNA sequencing spatial transcriptomic analysis 143 macaque cortical regions, we obtained a comprehensive atlas 264 transcriptome-defined cell types mapped their distribution across entire cortex. We characterized layer region preferences glutamatergic, GABAergic, non-neuronal types, as well regional differences in cell-type composition...
Safe, efficacious, and deployable vaccines are urgently needed to control COVID-19 in the large-scale vaccination campaigns. We report here preclinical studies of an approved protein subunit vaccine against COVID-19, ZF2001, which contains tandem-repeat dimeric receptor-binding domain (RBD) with alum-based adjuvant. assessed immunogenicity efficacy both mice non-human primates (NHPs). ZF2001 induced high levels RBD-binding SARS-CoV-2 neutralizing antibody primates, elicited balanced TH1/TH2...
Surgical removal of primary tumors reverses tumor-mediated immune suppression in pre-clinical models with metastatic disease. However, how cytoreductive surgery the setting modulates responses patients, especially context checkpoint therapy (ICT), is not understood. We report first prospective, pilot, non-comparative clinical trial (NCT02210117) to evaluate feasibility, benefits, and immunologic changes combining three different ICT-containing strategies or biopsy for patients clear cell...
The BIG Data Center at Beijing Institute of Genomics (BIG) the Chinese Academy Sciences provides a suite database resources in support worldwide research activities both academia and industry. With vast amounts multi-omics data generated unprecedented scales rates, is continually expanding, updating enriching its core through big integration value-added curation. Resources with significant updates past year include BioProject (a biological project library), BioSample sample Genome Sequence...
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that plays an important role in the expression of genes, whose function exerted through protein–protein interactions (PPIs), such as transcriptional co-activator (CREB)-binding protein (CBP) and p300. Under hypoxic conditions, HIF-1is stabilized translocated to CBP or p300, leading response cascade. Furthermore, PPI between HIF p300/CBP potential cancer target for their response. In this study, molecular dynamics (MD) simulation...
The diversity and heterogeneity within high-grade serous ovarian cancer (HGSC), which is the most lethal gynecologic malignancy, not well understood. Here, we perform comprehensive multi-platform omics analyses, including integrated analysis, immune monitoring on primary metastatic sites from highly clinically annotated HGSC samples based a laparoscopic triage algorithm patients who underwent complete gross resection (R0) or received neoadjuvant chemotherapy (NACT) with excellent poor...
Abstract Severe acute respiratory syndrome CoV-2 (SARS-CoV-2) caused the Corona Virus Disease 2019 (COVID-19) cases in China has become a public health emergency of international concern (PHEIC). Based on angiotensin converting enzyme 2 (ACE2) as cell entry receptor SARS-CoV, we used hACE2 transgenic mice infected with SARS-CoV-2 to study pathogenicity virus. Weight loss and virus replication lung were observed SARS-CoV-2. The typical histopathology was interstitial pneumonia infiltration...
Abstract Expression profiles of long non-coding RNAs (lncRNAs) across diverse biological conditions provide significant insights into their functions, interacting targets as well transcriptional reliability. However, there lacks a comprehensive resource that systematically characterizes the expression landscape human lncRNAs by integrating wide range conditions. Here, we present LncExpDB (https://bigd.big.ac.cn/lncexpdb), an database is devoted to providing lncRNA genes, exploring features...