A5100324112- Genomics and Phylogenetic Studies
- Advanced biosensing and bioanalysis techniques
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Electrocatalysts for Energy Conversion
- Advanced Photocatalysis Techniques
- Nonlinear Partial Differential Equations
- Microbial Natural Products and Biosynthesis
- Advanced battery technologies research
- CRISPR and Genetic Engineering
- Plant and Fungal Species Descriptions
- Biosensors and Analytical Detection
- Genomics and Chromatin Dynamics
- Advanced Mathematical Modeling in Engineering
- Cancer-related molecular mechanisms research
- Molecular Biology Techniques and Applications
- Asymmetric Synthesis and Catalysis
- Insect Resistance and Genetics
- Geometric Analysis and Curvature Flows
- Gold and Silver Nanoparticles Synthesis and Applications
- Photosynthetic Processes and Mechanisms
- Cancer-related gene regulation
- Plant Reproductive Biology
- Genomics and Rare Diseases
Chinese Academy of Sciences
2005-2025
Shenzhen Institutes of Advanced Technology
2021-2025
Northeast Agricultural University
2024
University at Buffalo, State University of New York
2024
University of Chinese Academy of Sciences
2018-2024
Institute of Biophysics
2018-2024
Shanghai Institute of Ceramics
2021-2024
People's Hospital of Xinjiang Uygur Autonomous Region
2024
Zhengzhou University
2023-2024
Czech Academy of Sciences, Institute of Biophysics
2024
Abstract NONCODE (http://www.noncode.org/) is a comprehensive database of collection and annotation noncoding RNAs, especially long non-coding RNAs (lncRNAs) in animals. NONCODEV6 dedicated to providing the full scope lncRNAs across plants The number has increased from 548 640 644 510 since last update 2017. human 172 216 173 112. mouse 131 697 974. plant 94 697. relationship between cancer were updated with transcriptome sequencing profiles. Three important new features also introduced...
PIWI-interacting RNAs are a class of small that is most abundantly expressed in animal germline. Substantial research going on to reveal the functions piRNAs epigenetic and post-transcriptional regulation transposons genes. To collect annotate these data, we developed piRBase, database assisting piRNA functional study. Since its launch 2014, piRBase has integrated 264 data sets from 21 organisms, number collected reached 173 million. The latest release (v2.0, 2018) was more focused...
Abstract The National Genomics Data Center (NGDC), which is a part of the China for Bioinformation (CNCB), provides family database resources to support global academic and industrial communities. With rapid accumulation multi-omics data at an unprecedented pace, CNCB-NGDC continuously expands updates core through big archiving, integrative analysis value-added curation. Importantly, NGDC collaborates closely with major international databases initiatives ensure seamless exchange...
0. Introduction.Various singularly perturbed elliptic equations have attracted much attention recently; see for example A. Floer and Weinstein [13], Y
Parenchymatous organs consist of multiple cell types, primarily defined as parenchymal cells (PCs) and nonparenchymal (NPCs). The cellular characteristics these are not well understood. Proteomic studies facilitate the resolution molecular details different types in organs. These have significantly extended our knowledge about organogenesis organ composition. Here, we present an atlas cell-type-resolved liver proteome. In-depth proteomics identified 6000 to 8000 gene products (GPs) for each...
The lack of haplotype reference panels and whole-genome sequencing resources specific to the Chinese population has greatly hindered genetic studies in world's largest population. Here, we present NyuWa genome resource, based on deep (26.2×) 2,999 individuals, construct a panel 5,804 haplotypes 19.3 million variants, which is high-quality publicly available population-specific with thousands samples. Compared other panels, reduces Han imputation error rate by margin ranging from 30% 51%....
Piwi-interacting RNAs are a type of small noncoding RNA that have various functions. piRBase is manually curated resource focused on assisting piRNA functional analysis. release v3.0 committed to providing more comprehensive related information. The latest covers >181 million unique sequences, including 440 datasets from 44 species. More disease-related piRNAs and targets been collected displayed. regulatory relationships between visualized. In addition the reuse expansion content in...
As effective ways to regulate protein levels, targeted degradation technologies have attracted great attention in recent years. Here, we established a novel integrin-facilitated lysosomal (IFLD) strategy degrade extracellular and cell membrane proteins using bifunctional compounds as molecular degraders. By conjugation of target protein-binding ligand with an integrin-recognition ligand, the resulting degrader proved be highly efficient induce internalization subsequent or integrin-...
The hollow core–shell Mo-NiS x @NiFe LDH/NF catalyst combining the intrinsic merits of sulfides and LDH exhibits fast reaction kinetics electrochemical activity, leading to enhanced activity for OER HER superior stability.
Abstract Noncoding RNAs (ncRNAs) play key regulatory roles in biological processes by interacting with other biomolecules. With the development of high-throughput sequencing and experimental technologies, extensive ncRNA interactions have been accumulated. Therefore, we updated NPInter database to a fifth version document these interactions. interaction entries were doubled from 1 100 618 2 596 695 manual literature mining data processing. We integrated global RNA–DNA iMARGI, ChAR-seq...
Soluble amyloid-β oligomers (AβOs) are proposed to instigate and mediate the pathology of Alzheimer's disease, but mechanisms involved not clear. In this study, we reported that AβOs can undergo liquid–liquid phase separation (LLPS) form liquid-like droplets in vitro. We determined exhibited an α-helix conformation a membrane-mimicking environment SDS. Importantly, SDS is capable reconfiguring assembly different induce their LLPS. Moreover, found droplet formation was promoted by strong...
Abstract Exploring efficient transition‐metal‐based electrocatalysts for oxygen evolution reaction (OER) is imperative but remain challenging sustainable energy storage and conversion systems. Foreign species doping a significant regulation strategy to enhance the intrinsic activity of host matrix. However, potential relationship structure‐activity caused by guest elements seldom tracked systematically. In this case, both theoretical screening experimental verification are complementarily...
Short tandem repeats (STRs) are abundant and highly mutagenic in the human genome. Many STR loci have been associated with a range of genetic disorders. However, most population-scale studies on variation humans focused European ancestry cohorts or limited by sequencing depth. Here, we depicted comprehensive map 366,013 polymorphic STRs (pSTRs) constructed from 6487 deeply sequenced genomes, comprising 3983 Chinese samples (~31.5x, NyuWa) 2504 1000 Genomes Project (~33.3x, 1KGP). We found...
Lateral flow immunoassay (LFIA) has been widely used for the early diagnosis of diseases. However, conventional colorimetric LFIA possesses limited sensitivity, and single-mode readout signal is easily affected by external environment, leading to insufficient accuracy. Herein, multifunctional Fe3O4@MoS2@Pt nanotags with a unique "pompon mum"-like structure were triumphantly prepared, exhibiting excellent peroxidase (POD)-like activity, photothermal properties, magnetic separation capability....
Abstract Small proteins specifically refer to consisting of less than 100 amino acids translated from small open reading frames (sORFs), which were usually missed in previous genome annotation. The significance has been revealed current years, along with the discovery their diverse functions. However, systematic annotation is still insufficient. SmProt was specially developed provide valuable information on for scientific community. Here we present update SmProt, emphasizes reliability...
Mobile element insertions (MEIs) are a major class of structural variants (SVs) and have been linked to many human genetic disorders, including hemophilia, neurofibromatosis, various cancers. However, MEI resources from large-scale genome sequencing still lacking compared those for SNPs SVs. Here, we report comprehensive map 36 699 non-reference MEIs constructed 5675 genomes, comprising 2998 Chinese samples (∼26.2×, NyuWa) 2677 the 1000 Genomes Project (∼7.4×, 1KGP). We discovered that...