A5004592229- Genetic Associations and Epidemiology
- Epigenetics and DNA Methylation
- Bioinformatics and Genomic Networks
- Genetic Mapping and Diversity in Plants and Animals
- Amyotrophic Lateral Sclerosis Research
- Genetic Syndromes and Imprinting
- Neurogenetic and Muscular Disorders Research
- Neurological diseases and metabolism
- COVID-19 Clinical Research Studies
- Advanced Antenna and Metasurface Technologies
- SARS-CoV-2 and COVID-19 Research
- Microwave Engineering and Waveguides
- Genomics and Phylogenetic Studies
- Microscopic Colitis
- Gene expression and cancer classification
- Single-cell and spatial transcriptomics
- Phytochemicals and Antioxidant Activities
- Silicon Nanostructures and Photoluminescence
- Semiconductor materials and devices
- Millimeter-Wave Propagation and Modeling
- Silicon Carbide Semiconductor Technologies
- Antenna Design and Analysis
- Genomics and Chromatin Dynamics
- Bluetooth and Wireless Communication Technologies
- Light effects on plants
Beijing Institute of Genomics
2021-2024
Chinese Academy of Sciences
2010-2024
University of Chinese Academy of Sciences
2021-2023
Shanghai Center For Bioinformation Technology
2021-2023
Wageningen University & Research
2022
Hunan University of Traditional Chinese Medicine
2020
Nanjing University of Science and Technology
2016
Changchun Institute of Optics, Fine Mechanics and Physics
2010
The National Genomics Data Center (NGDC), part of the China for Bioinformation (CNCB), provides a family database resources to support global academic and industrial communities. With explosive accumulation multi-omics data generated at an unprecedented rate, CNCB-NGDC constantly expands updates core by big archive, integrative analysis value-added curation. In past year, efforts have been devoted integrating multiple omics data, synthesizing growing knowledge, developing new upgrading set...
Abstract The National Genomics Data Center (NGDC), which is a part of the China for Bioinformation (CNCB), provides family database resources to support global academic and industrial communities. With rapid accumulation multi-omics data at an unprecedented pace, CNCB-NGDC continuously expands updates core through big archiving, integrative analysis value-added curation. Importantly, NGDC collaborates closely with major international databases initiatives ensure seamless exchange...
Background The immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are crucial in maintaining a delicate balance between protective effects and harmful pathological reactions that drive the progression of disease 2019 (COVID-19). T cells play significant role adaptive antiviral responses, making it valuable investigate heterogeneity diversity SARS-CoV-2-specific cell COVID-19 patients with varying severity. Methods In this study, we employed high-throughput...
Large-scale genome-wide association studies (GWAS) have provided profound insights into complex traits and diseases. Yet, deciphering the fine-scale molecular mechanisms of how genetic variants manifest to cause phenotypes remains a daunting task. Here, we present COLOCdb (https://ngdc.cncb.ac.cn/colocdb), comprehensive colocalization database by integrating more than 3000 GWAS summary statistics 13 types xQTL date. By employing two representative approaches for analysis, deposits results...
A broad range of complex phenotypes are related to dysfunctions in brain (hereafter referred as brain-related traits), including various mental and behavioral disorders diseases the nervous system. These traits general share overlapping symptoms, pathogenesis, genetic components. Here, we present Brain Catalog (https://ngdc.cncb.ac.cn/braincatalog), a comprehensive database aiming delineate components more than 500 GWAS summary statistics datasets for from multiple aspects. First, provides...
Amyotrophic lateral sclerosis (ALS) is a fatal progressive multisystem disorder with limited therapeutic options. Although genome-wide association studies (GWASs) have revealed multiple ALS susceptibility loci, the exact identities of causal variants, genes, cell types, tissues, and their functional roles in development remain largely unknown. Here, we reported comprehensive post-GWAS analysis recent large GWAS (n = 80,610), including mapping annotation (FUMA), transcriptome-wide study...
Abstract Annotating genetic variants to their target genes is of great importance in unraveling the causal and mechanisms that underlie complex diseases. However, disease-associated are often located non-coding regions manifest context-specific effects, making it challenging accurately identify regulatory mechanisms. Here, we present TargetGene (https://ngdc.cncb.ac.cn/targetgene/), a comprehensive database reporting for human from various aspects. Specifically, collected catalog multi-omics...
A dual-polarization higher order mode substrate integrated cavity (SIC) antenna array operating in Ka band is proposed. Cross-shaped radiating slots are employed to achieve the dual polarization performance. An 8×8-elements designed by using three layers of double-side printed circuit broads (PCBs), which composed two feeding networks and one layer elements. For better expansibility efficiency, full corporate waveguide (SIW) specially a 2×2-slot subarray excited SIC presented. Simulated...
Gap waveguide (GW) was investigated to realize low loss millimeter wave (mm-wave) transmission line in recent years. In this paper, groove gap (GGW) is used design a W band filter antenna array. A 14 slots array with center fed structure and fourth order cavity bandpass are designed respectively. Then the method of integration combining eliminate transition between two parts. Simulation result shows an gain 18.64dBi side lobe level (SLL) 20.64dB at frequency 94.55GHz. Interference signal...
Abstract Summary Here we describe fastQTLmapping, a C++ package that is computationally efficient not only for mQTL-like analysis but as generic solver also conducting exhaustive linear regressions involving extraordinarily large numbers of dependent and explanatory variables allowing covariates. Compared to the state-of-the-art MatrixEQTL, fastQTLmapping was an order magnitude faster with much lower peak memory usage. In dataset consisting 3,500 individuals, 8 million SNPs, 0.8 CpGs 20...
This paper presents a novel millimeter wave (mmW) phased array-based communication system to provide reliable data link between maglev trains and ground control systems. is composed of active array, baseband interface components. In this train-to-ground application scenario, the array used better coverage lower cost stronger capability resistance spatial interference. The designed have an effective isotropic radiation power (EIRP) more than 50 dBm at 28 GHz, with 3-dB beamwidth 12 degree,...
Abstract Amyotrophic lateral sclerosis (ALS) is a fatal progressive multisystem disorder with limited therapeutic options. Although genome-wide association studies (GWASs) have revealed multiple ALS susceptibility loci, unraveling causal relationships between genetic variants, genes, cell types, tissues, and risk of remains challenging. Here, we reported comprehensive post-GWAS analysis the recent large GWAS (n = 80610), including functional mapping annotation (FUMA), transcriptome-wide...
Abstract Identification and characterization of methylation quantitative trait loci (mQTLs) can help elucidate the role DNA changes as a potential mediator genetic risk loci. However, mQTLs remain poorly characterized: they have not yet been mapped in largest ethnic populations, their cell-type specific nature has resolved, proportion attributed to different molecular mechanisms is unknown. Here we perform first mQTL-mapping study large Han Chinese population, demonstrating that over 80% are...