A5101745144- Glycosylation and Glycoproteins Research
- Animal Ecology and Behavior Studies
- Ecology and Vegetation Dynamics Studies
- Retinoids in leukemia and cellular processes
- Stress Responses and Cortisol
- Plant and animal studies
- RNA Interference and Gene Delivery
- Cancer Cells and Metastasis
- Ubiquitin and proteasome pathways
- Genomics and Phylogenetic Studies
- Neuroscience and Neuropharmacology Research
- Genetic diversity and population structure
- Wildlife Ecology and Conservation
- Genomic variations and chromosomal abnormalities
- Protein Kinase Regulation and GTPase Signaling
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Estrogen and related hormone effects
- Cancer-related Molecular Pathways
- Axon Guidance and Neuronal Signaling
- Nuclear Receptors and Signaling
- Cell death mechanisms and regulation
- Animal Vocal Communication and Behavior
- Lepidoptera: Biology and Taxonomy
- Literacy, Media, and Education
Anhui University
2025
National Louis University
2022-2025
National College
2025
First Affiliated Hospital of Fujian Medical University
2024
Fujian Medical University
2024
Harbin Medical University
2009-2024
Second Affiliated Hospital of Harbin Medical University
2010-2024
Shaanxi Institute of Zoology
2012-2023
Fudan University
2007-2023
Jiangsu Province Hospital
2023
The National Genomics Data Center (NGDC), part of the China for Bioinformation (CNCB), provides a family database resources to support global academic and industrial communities. With explosive accumulation multi-omics data generated at an unprecedented rate, CNCB-NGDC constantly expands updates core by big archive, integrative analysis value-added curation. In past year, efforts have been devoted integrating multiple omics data, synthesizing growing knowledge, developing new upgrading set...
Serotonin reuptake transporter (SERT) is a key regulator of serotonin neurotransmission and major target antidepressants. Antidepressants, such as selectively inhibitors (SSRIs), that block SERT function are known to affect food intake body weight. Here, we provide genetic evidence metabolism regulated by separable mechanisms function. SERT-deficient mice ate less during both normal diet high fat feeding. The reduced was accompanied with markedly elevated plasma leptin levels. Despite...
Polymorphisms that alter serotonin transporter SERT expression and functionality increase the risks for autism psychiatric traits. Here, we investigate how controls signaling in developing CNS mice. is transiently expressed specific sets of glutamatergic neurons uptakes extrasynaptic during perinatal development. We show thalamocortical axons (TCAs) dictates sensory map architecture. Knockout TCAs causes lasting alterations TCA patterning, spatial organizations cortical neurons, dendritic...
The quiescent/slow-cycling state preserves the self-renewal capacity of cancer stem cells (CSCs) and leads to therapy resistance CSCs. mechanisms maintaining CSCs quiescence remain largely unknown. Here, it is demonstrated that lower expression MAN1A1 in glioma cell (GSC) resulted formation high-mannose type N-glycan on CD133. Furthermore, CD133 necessary for its interaction with DNMT1. Activation p21 p27 by CD133-DNMT1 maintains slow-cycling GSC, promotes chemotherapy tumorigenesis GSCs....
The elevated levels of beta1,4-galactosyltransferase I (GalT I; EC 2.4.1.38) are detected in highly metastatic lung cancer PGBE1 cells compared with its less partner PGLH7 cells. Decreasing the GalT surface expression by small interfering RNA or function mutation inhibited cell adhesion on laminin, invasive potential vitro, and tyrosine phosphorylation focal kinase. mechanism which activity is up-regulated remains unclear. To investigate regulation expression, we cloned 5'-region flanking...
ABSTRACT In this study, a non‐invasive device based on ultraviolet differential absorption spectroscopy (UV‐DOAS) technology for detecting fractional exhaled nitric oxide (FeNO)was developed and clinically validated in patients with various lung diseases. The diagnostic potential of FeNO was explored by analysing subgroups cancer, nodules, other disease. results showed that concentrations were significantly higher malignant tumours than healthy controls ( p < 0.01). efficacy different...
This study investigates how Chinese American children construct their identities in self-created multimodal discourses. Drawing from discourse and critical visual literacy, the research analyzes discourses created by eight children, including illustrations, texts, oral explanations. The findings reveal that these dual representations of identity—depicting themselves as both ordinary distinctive. These portrayals simultaneously align with challenge stereotypical depictions Americans dominant...
// Ying Liu 1,* , Shifang Ren Liqi Xie 2 Chunhong Cui 1 Yang Xing Chanjuan Benjin Cao Fan Yinan Li Xiaoning Chen Yuanyan Wei Haojie Lu and Jianhai Jiang Key Laboratory of Glycoconjuates Research, Ministry Public Health Gene Research Center, Department Biochemistry Molecular Biology, Shanghai Medical College Fudan University, Shanghai, People's Republic China Institutes Biomedical Sciences * These authors have contributed equally to this work Correspondence to: Jiang, email: Lu, Wei, Keywords...
INTRODUCTION: Anticoagulation therapy in portal vein thrombosis (PVT) patients with cirrhosis is still a matter of debate. Therefore, the aim this work was to evaluate efficacy and safety nadroparin calcium-warfarin sequential (NWS) anticoagulation cirrhotic find an optimal strategy. METHODS: Consecutive PVT who have not received were randomly divided into NWS group (1-month calcium by subcutaneous injection followed 5-month warfarin oral administration) control (no therapy). Overall...
Sialic acid-binding immunoglobulin-like lectin-15 (Siglec-15) has been identified as a novel potential target for cancer immunotherapy. Here, we explored the role of Siglec-15 in human hepatoma cells. In this study, found that expression is substantially upregulated liver tissues comparison with nontumor tissues. Functionally, vitro experiments show promotes migration Furthermore, data demonstrated an interaction between and CD44, transmembrane glycoprotein mediates tumor progression...
Liver hepatocellular carcinoma (LIHC) is one of the most common malignant tumors, which difficult to be diagnosed at an early stage due its poor prognosis. Despite fact that PANoptosis important in occurrence and development no bioinformatic explanation related LIHC can found. A bioinformatics analysis on data patients TCGA database was carried out basis previously identified PANoptosis-related genes (PRGs). were divided into two PRG clusters whose gene characteristics differentially...
Abstract Targeting the niche components surrounding glioblastoma stem cells (GSCs) helps to develop more effective treatments. However, mechanisms underlying crosstalk between GSCs and microenvironment remain largely unknown. Clarifying extracellular molecules binding marker CD133 elucidate mechanism of communication microenvironment. Here, it is found that domain high mannose type physically interacts with Collagen 1 (COL1) in GSCs. COL1, mainly secreted by cancer‐associated fibroblasts, a...
Anoikis-Related Genes (ARGs) lead to the organism manifesting resistance anoikis and are associated with unfavorable prognostic outcomes across various malignancies.Therefore, it is crucial identify pivotal target genes related in HCC .We found that ARGs were significantly correlated prognosis immune responses HCC. The core gene, SPP1, notably promoted metastasis through both vivo vitro studies. PI3K-Akt-mTOR pathway played a critical role suppression within contexts. Our research unveiled...
Arsenic trioxide (ATO) is of limited therapeutic benefit for the treatment solid tumors. Genistein exhibits anticancer and pro‐oxidant activities, making it a potential candidate to enhance efficacy ATO whose cytotoxicity oxidation‐sensitive. This study sought determine whether genistein synergizes with combat hepatocellular carcinoma (HCC). Three human HCC cell lines, namely HepG2, Hep3B, SK‐Hep‐1, were incubated ATO, genistein, or + genistein. The cells also pretreated antioxidant agents...
CD133 is widely used as a marker to isolate tumor-initiating cells in many types of cancers. The structure N-glycan on altered during the differentiation cells. However, relationship between N-glycosylation and stem cell characteristics remains elusive. Here, we found that level α-1,2-mannosylated was associated with stemness genes intrahepatic cholangiocarcinoma (iCCA) tissues. CD133+ possessed loss Golgi α-mannosidase I coding gene MAN1C1 resulted formation iCCA-initiating Mechanistically,...