A5075858981- Immune cells in cancer
- Ferroptosis and cancer prognosis
- Macrophage Migration Inhibitory Factor
- Phagocytosis and Immune Regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- Energy Harvesting in Wireless Networks
- RNA modifications and cancer
- Coastal wetland ecosystem dynamics
- Cancer, Hypoxia, and Metabolism
- Immune Cell Function and Interaction
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- IoT and Edge/Fog Computing
- Cancer Immunotherapy and Biomarkers
- Peptidase Inhibition and Analysis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease and Transplantation
- Renal cell carcinoma treatment
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic and Hepatic Oncology Research
- Endoplasmic Reticulum Stress and Disease
- Ga2O3 and related materials
- ZnO doping and properties
- Drug Transport and Resistance Mechanisms
Fudan University
2016-2025
Zhongshan Hospital
2016-2025
University of Electronic Science and Technology of China
2021-2025
The University of Texas MD Anderson Cancer Center
2006-2024
Sir Run Run Shaw Hospital
2022-2024
Zhejiang University
2022-2024
Songjiang District Central Hospital
2024
Shanghai Jiao Tong University
2012-2024
Shanghai First People's Hospital
2017-2024
Institute of Psychology, Chinese Academy of Sciences
2021-2024
Sorafenib is a first-line molecular-target drug for advanced hepatocellular carcinoma (HCC), but its clinical effects are still limited. In this study we identify Quiescin sulfhydryl oxidase 1 (QSOX1) acting as cellular pro-oxidant, specifically in the context of sorafenib treatment HCC. QSOX1 disrupts redox homoeostasis and sensitizes HCC cells to oxidative stress by inhibiting activation master antioxidant transcription factor NRF2. A negative correlation between NRF2 expression was...
Tumor-associated macrophages (TAMs), which form a large part of the tumor microenvironment, are normally regulated by metabolic reprogramming. However, potential mechanisms immune-metabolism interaction between hepatocellular carcinoma (HCC) cells and TAMs remain unclear.The candidate long non-coding RNAs (lncRNAs) were screened Smart-seq based scRNA-seq method then validated qPCR. Immunostaining analysis was done to examine levels markers for glycolysis. Exosomes from primary human HCC...
Hepatocellular carcinoma (HCC) remains one of the most refractory malignancies worldwide. Schlafen family member 11 (SLFN11) has been reported to play an important role in inhibiting production human immunodeficiency virus 1 (HIV-1). However, whether SLFN11 also inhibits hepatitis B (HBV), and affects HBV-induced HCC remain be systematically investigated. Methods: qRT-PCR, western blot immunohistochemical (IHC) staining were conducted investigate potential prognostic value HCC. Then was...
Guanosine triphosphate binding protein 4 (GTPBP4) is a key regulator of cell cycle progression and MAPK activation. However, how its biological properties intersect with cellular metabolism in hepatocellular carcinoma (HCC) development remains poorly unexplained. Here, high GTPBP4 expression found to be significantly associated worse clinical outcomes patients HCC. Moreover, upregulation paralleled by DNA promoter hypomethylation regulated DNMT3A, methyltransferase. Additionally, both gain-...
Background Hepatocellular carcinoma (HCC) is a malignancy with limited treatment options and poor prognosis. Macrophages are enriched in the HCC microenvironment have significant impact on disease progression therapy efficacy. We aim to identify critical macrophages subsets involved development. Methods Macrophage-specific marker genes were identified through single-cell RNA sequencing analyses. The clinical significance of palmitoyl-protein thioesterase 1 (PPT1) positive was investigated...
Immune checkpoint inhibitors have limited efficacy in hepatocellular carcinoma (HCC). Macrophages are the most abundant immune cells HCC, suggesting that a better understanding of intrinsic processes by which tumor regulate macrophages could help identify strategies to improve response immunotherapy. As signaling lymphocytic activation molecule (SLAM) family members various functions, we investigated role specific SLAM receptors immunobiology HCC. Comparison transcriptomic landscapes...
Abstract Tumor-secreted factors contribute to the development of a microenvironment that facilitates escape cancer cells from immunotherapy. In this study, we conduct retrospective comparison proteins secreted by hepatocellular carcinoma (HCC) in responders and non-responders among cohort ten patients who received Nivolumab (anti-PD-1 antibody). Our findings indicate have high abundance RNase1, which is associated with poor prognosis various types. Furthermore, mice implanted HCC overexpress...
Osteosarcoma (OS) has an unfavorable prognosis and tends to metastasize lung tissue. Although the CXCL12-CXCR4 axis appears affect progression metastasis in numerous tumors, its mechanism downstream pathways OS remain unclear. We used western blotting flow cytometry detect CXCR4 CXCR7 expression two cell lines (LM8 Dunn). An MTT assay was evaluate effects of CXCL12 AMD3100, a specific antagonist, on viability. Flow utilized analyze changes apoptosis induced by serum deprivation following...
The Chinese Altay is located in the western segment of Central Asian Orogenic Belt (CAOB) and preserves critical records Paleo-Asian Ocean (PAO) Plate evolution during Paleozoic era. This region also hosts significant mineral deposits, making it a focal point for geological research. In this paper, field investigation, petrology, mineralogy, petrography studies were conducted on volcanic rocks Change to “Fuyun–Qinghe area, southern margin Altay, paper provided new zircon LA-ICP-MS dating...
Ovarian cancer is developed from a single layer of thin epithelial cells covering the surface ovary, named human ovarian cells. Like all primary cells, have finite life span and will go into senescence eventually die when cultured in vitro. Immortalized provide an important model system with which to study initiation progression. Here, we show that silencing p53 expression retrovirus-mediated small interfering RNA can delay extend cell passage number, but not sufficient immortalize normal...
G2 and S phase-expressed-1 (GTSE1) was recently reported to upregulate in several types of human cancer, based on negatively regulate p53 expression. However, its expression functional roles hepatocellular carcinoma (HCC) remain unknown. In this study, GTSE1 observed be highly expressed HCC specimens cell lines both at messenger RNA (mRNA) protein levels. Furthermore, high positively associated with tumor size, venous invasion, advanced stage, short overall survival. Moreover, we generated...
Abstract Hepatocellular carcinoma (HCC) is one of the top three cancer killers worldwide. To identify CNV-driven differentially expressed genes (DEGs) in HBV related HCC, this study integrated analysis copy number variations (CNVs) and gene expression profiling. Significant regions CNVs were overlapped with those obtained from 93 exhibiting increased duplicated 45 showing decreased deleted obtained, which duplications deletions mainly documented at chromosome 1 4. Functional pathway...