A5036937101- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal cell carcinoma treatment
- Endoplasmic Reticulum Stress and Disease
- Epigenetics and DNA Methylation
- Kruppel-like factors research
- Cancer, Lipids, and Metabolism
- Cancer Mechanisms and Therapy
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Genetics and Neurodevelopmental Disorders
- Cancer-related gene regulation
- Single-cell and spatial transcriptomics
- Cancer Cells and Metastasis
- MRI in cancer diagnosis
- Global Healthcare and Medical Tourism
- Cancer-related molecular mechanisms research
- Minimally Invasive Surgical Techniques
- Genomic variations and chromosomal abnormalities
- Chemical Reactions and Isotopes
Zhongshan Hospital
2017-2025
Fudan University
2017-2025
China-Japan Friendship Hospital
2017-2025
Cancer Institute (WIA)
2019
Ministry of Education of the People's Republic of China
2018-2019
Sun Yat-sen University
2017-2019
The First Affiliated Hospital, Sun Yat-sen University
2017-2019
SAIC-GM (China)
2019
Peking University
2017
Hepatocellular carcinoma (HCC) remains one of the most refractory malignancies worldwide. Schlafen family member 11 (SLFN11) has been reported to play an important role in inhibiting production human immunodeficiency virus 1 (HIV-1). However, whether SLFN11 also inhibits hepatitis B (HBV), and affects HBV-induced HCC remain be systematically investigated. Methods: qRT-PCR, western blot immunohistochemical (IHC) staining were conducted investigate potential prognostic value HCC. Then was...
Guanosine triphosphate binding protein 4 (GTPBP4) is a key regulator of cell cycle progression and MAPK activation. However, how its biological properties intersect with cellular metabolism in hepatocellular carcinoma (HCC) development remains poorly unexplained. Here, high GTPBP4 expression found to be significantly associated worse clinical outcomes patients HCC. Moreover, upregulation paralleled by DNA promoter hypomethylation regulated DNMT3A, methyltransferase. Additionally, both gain-...
714 Background: Over half of pancreatic cancer patients present with advanced disease and distant metastases, primarily in the liver, at initial diagnosis. Although systemic combination therapies have improved outcomes, role surgery remains contentious. This study seeks to pinpoint prognostic factors for synchronous liver metastatic (sPDACLM) who receive effective treatments, identify likely benefit from surgery. Methods: is a retrospective cohort study. Included received first-line...
Abstract Hepatocellular carcinoma (HCC) is one of the top three cancer killers worldwide. To identify CNV-driven differentially expressed genes (DEGs) in HBV related HCC, this study integrated analysis copy number variations (CNVs) and gene expression profiling. Significant regions CNVs were overlapped with those obtained from 93 exhibiting increased duplicated 45 showing decreased deleted obtained, which duplications deletions mainly documented at chromosome 1 4. Functional pathway...
Glutamate-cysteine ligase catalytic subunit (GCLC) has been reported to overexpress in a variety types of cancer and be related with tumor progression drug resistance. However, little known about GCLC's prognostic significance biological roles hepatocellular carcinoma (HCC). In the present study, we evaluated GCLC expression level using immunohistochemical staining (IHC) tissue microarray (TMA) containing paired peritumoral liver tissues from 168 patients HCC who received curative resection....
The definition of textbook outcome in biliary system cancers is a developing concept need expansion and investigation its association with survival quality life.
<b><i>Introduction:</i></b> This study aimed to evaluate associations between frailty and outcomes in patients with intrahepatic cholangiocarcinoma (ICC) undergoing hepatic lobectomy using a large, nationally representative sample. <b><i>Methods:</i></b> population-based, retrospective observational extracted the data of adults ≥20 years old ICC from US Nationwide Inpatient Sample database 2005 2018. Frailty was assessed by validated Hospital...
Ribosomal protein S11 (RPS11), a member of ribosomal family, is reported to overexpress in diverse malignancies and correlates with tumor recurrence. However, our current knowledge on RPS11 hepatocellular carcinoma (HCC) remains limited. In this study, we are going explore the potential prognostic value HCC patients after curative resection.Immunohistochemistry (IHC) was performed evaluate expression tissue microarrays training cohort comprising 182 validation enrolling 90 Zhongshan...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal malignancies worldwide.PDAC prognostic and diagnostic biomarkers are still being explored.The aim this study to establish a robust molecular signature that can improve ability predict PDAC prognosis.155 overlapping differentially expressed genes between tumor non-tumor tissues from three Gene Expression Omnibus (GEO) datasets were explored.A least absolute shrinkage selection operator method (LASSO) Cox regression model was...
Background: Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive solid malignant tumors worldwide. Increasing investigations demonstrate that long non-coding RNAs (lncRNAs) expression is abnormally dysregulated in cancers. It crucial to identify and predict prognosis patients for selection further therapeutic treatment. Methods: PDAC lncRNAs abundance profiles were used establish a signature could better patients. The least absolute shrinkage operator (LASSO) Cox...
WW domain-containing oxidoreductase (WWOX), which has a protein-interaction domain and is regarded to be tumor suppressor, been known play an important role in anti-angiogenesis cancer progression. This study aimed investigate prognostic values of WWOX expression hepatocellular carcinoma (HCC) patients after hepatectomy. Additionally, we intended formulate valuable nomogram for HCCs. 182 HCC who underwent hepatectomy from January 2009 2010 were enrolled our study. qRT-PCR, Western blot,...
Microvascular invasion (MVI) is a significant hazard factor that influences the recurrence and survival of hepatocellular carcinoma (HCC) patients after undergoing hepatectomy. This study aimed to develop validate nomogram combines hematological imaging features HCC preoperatively predict MVI, investigate effect wide resection margin (≥1 cm) on prognosis MVI-positive patients.A total 709 who underwent hepatectomy at Liver Cancer Institute Zhongshan Hospital, Fudan University between June 1,...
Introduction: The WW domain-containing oxidoreductase (WWOX), widely expressed in human tissues, is considered as a tumor suppressor gene and plays an important role the incidence progression of cancer, HCC included. This study was to investigate correlation between single nucleotide polymorphisms (SNPs) WWOX prognosis hepatocellular carcinoma (HCC) patients. Materials Methods: After total 152 patients were recruited, 8 cases with recurrence within 2-years after operation without selected...
Nuclear factor (erythroid-derived 2)-like 2 (NRF2) functions decline with age; however, cancer cells can hijack its pathways to ensure survival and aggressiveness. Yet, the role of NRF2 in hepatocellular carcinoma (HCC) is rarely investigated an age-specific manner. This study investigates expression activator (MAPK10) different age groups HCC patients, addition features MAPK10 interaction their clinical significance.Tumor near-tumor tissue samples 181 patients were used complete a protein...
Despite the rapid growing and aging of populations worldwide, our knowledge on hepatocellular carcinoma (HCC) is still age-standardized rather than age-specific, with only few studies exploring topic from a genetic point view. Here, we analyze clinical aspects HCC in patients different age groups major attention directed to children (≤20 y) elderly (≥80 y). A number significant differences were found compared group, including smaller tumor size (P=0.001) improved survival rates (P=0.002)....
Krüppel-like factor 4 (KLF4), a zinc-finger transcription in klfs family, is known for its crucial role regulating cell growth, proliferation, and differentiation. This research aimed to explore the prognostic significance of KLF4 hepatocellular carcinoma's (HCC) patients after curative resection HCC progression. There were 185 who had hepatectomy from July 2010 2011 included this study. expression was detected by microarray immunohistochemical technique, western blot, qRT-PCR. Then,...
Background: Hepatocellular carcinoma (HCC) is a malignant tumor with great variation in prognosis among individuals. Changes metabolism influence disease progression and clinical outcomes. The objective of this study was to determine the overall survival (OS) risk HCC patients from metabolic perspective. Patients Methods: model constructed using least absolute shrinkage selection operator (LASSO) COX regression based on Cancer Genome Atlas (TCGA, n=342) dataset. International Consortium...