A5101510965- Mesenchymal stem cell research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Immune Response and Inflammation
- Neurogenesis and neuroplasticity mechanisms
- Gastric Cancer Management and Outcomes
- RNA Research and Splicing
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA Interference and Gene Delivery
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Cancer, Stress, Anesthesia, and Immune Response
- interferon and immune responses
- Cell Adhesion Molecules Research
- S100 Proteins and Annexins
- Vascular Malformations and Hemangiomas
- Hemodynamic Monitoring and Therapy
- Hernia repair and management
- Sepsis Diagnosis and Treatment
- Biliary and Gastrointestinal Fistulas
- Extracellular vesicles in disease
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Virus-based gene therapy research
- Surgical site infection prevention
- Syphilis Diagnosis and Treatment
Marcus (United States)
2021-2024
China-Japan Friendship Hospital
2017-2024
Duke University
2016-2024
Bioscience (China)
2024
Yuhuangding Hospital
2023-2024
Shandong University
2024
Beijing Luhe Hospital Affiliated to Capital Medical University
2024
Qingdao University
2023
Peking Union Medical College Hospital
2022
Tongji Hospital
2022
Although the use of RNAs has enormous therapeutic potential, these RNA-based therapies can trigger unwanted inflammatory responses by activation pattern recognition receptors (PRRs) and cause harmful side effects. In contrast, immune be advantageous for treating cancers. Thus, immunogenicity should deliberately controlled depending on applications RNAs. this study, we demonstrated that containing 2'fluoro (2'F) pyrimidines differentially PRRs. The activity stimulate toll-like 3 7 was...
The definition of textbook outcome in biliary system cancers is a developing concept need expansion and investigation its association with survival quality life.
TATA-box-binding protein-associated Factor 15 (TAF15), a member of the FUS/EWS/TAF15 (FET) family, contributes to progression various tumours. However, role and molecular mechanism TAF15 in gastric cancer (GC) are still unknown. In this study, we found that was significantly upregulated GC tumour tissues cell lines. Overexpression associated with larger size, high pathologic stage T GC. knockdown suppressed proliferation, migration invasion cells vitro inhibited growth vivo. Additionally,...
To evaluate the efficacy and safety of intranasal insulin on postoperative cognitive dysfunction (POCD) in elderly patients after laparoscopic radical resection colorectal cancer.
Abstract Although guidelines recommend extended surgical resection, radical resection and lymphadenectomy for patients with tumor stage (T)1b gallbladder cancer, these procedures are substantially underutilized. This population‐based, retrospective cohort study aimed to evaluate treatment patterns outcomes of 401 using the US Surveillance, Epidemiology, End Results (SEER) database from 2004 2013. showed that median overall survival (OS) was 69 months 37 those without lymphadenectomy....
The biological function and molecular mechanism of nucleolar spindle-associated protein 1 (NUSAP1) in breast cancer remain controversial, this study aimed to reveal the NUSAP1 cell metastasis survival.The expression was evaluated by immunohistochemistry quantitative real-time polymerase chain reaction (RT-qPCR) tissue samples. correlation with clinicopathological parameters patients overall survival (OS) evaluated. detected Western blotting, proliferation Edu staining MTT assay, migration...
BACKGROUND: It remains unclear whether the benefits of performing perioperative allogeneic red blood cell (RBC) transfusion outweigh risks postoperative wound infection. The aim this study was to assess impact RBC as well dose–response relationship on infections in surgical patients a large cohort. METHODS: As retrospective observational study, national Hospital Quality Monitoring System database used retrieve information about in-hospital without limitations types People’s Republic China...
Activation of the RNA-sensing pattern recognition receptor (PRR) in cancer cells leads to cell death and cytokine expression. This releases tumor antigens damage-associated molecular patterns (DAMPs) that induce anti-tumor immunity. However, these cytokines DAMPs also cause adverse inflammatory thrombotic complications can limit overall therapeutic benefits PRR-targeting anti-cancer therapies. To overcome this problem, we generated evaluated two novel distinct ssRNA molecules (immunogenic...
The aim was to compare perioperative outcomes of hilar cholangiocarcinoma (HCCA) radical resection performed through the laparoscopic route or by open surgery in single-center cohort study.A retrospective study included all patients undergoing HCCA our center from January 2018 November 2019. Short-term with and were compared demographic characteristics, intraoperative postoperative parameters extent resection.Among 64 included, 34 30 surgery. Laparoscopic versus group associated a longer...
Pheochromocytoma is a rare catecholamine-secreting tumor. Tumor resection remains high-risk procedure due to intraoperative hemodynamic instability nowadays, which may lead myocardial injury. We aimed determine the incidence and associated risk factors for injury after laparoscopic adrenalectomy pheochromocytoma.Adult patients (n=350, American Society of Anesthesiology physical status 1-3) who underwent elective pheochromocytoma under general anesthesia between January 31, 2013 2020 were...
To improve minimally invasive outcomes, we designed a new procedure, lower abdominal laparoscopic cholecystectomy (LALC). This study was conducted to evaluate the effects of LALC versus classical (CLC) and single-incision (SILC) on reducing systemic acute inflammatory response, improving cosmesis, postoperative pain relief.Beginning from July 2014, 105 patients meeting inclusion criteria were randomly assigned three groups: LALC, CLC, SILC. The primary endpoint determination response...
Abstract In gastric cancer, gastrokine 1 (GKN1) is a potential theragnostic marker while the related mechanisms remain elusive. Exosomes mediate intercellular communications via transferring various molecules, yet there are limited research studies on specific cargos of cancer exosomes and associated in this disease. present study, AGS N87‐C cells were transfected with an overexpressed GKN1 plasmid, followed by extraction exosomes. The study utilized cell lines xenograft mouse model to...
Abstract Introduction Krabbe Disease (KD) is a rare neurodegenerative disorder caused by mutation in the gene encoding galactocerebrosidase (GALC). GALC deficiency leads to accumulation of toxic metabolite psychosine myelin-forming oligodendrocytes causing severe demyelination. Presymptomatic hematopoietic stem cell transplants can slow progression disease, but ultimately there no cure. We previously demonstrated that DUOC-01, first-generation macrophage cell-therapy manufactured from banked...
Human Papillomavirus (HPV) DNA screening was a crucial element in the fight against cervical cancer and had been adopted many countries, including China. However, onset of COVID-19 pandemic March 2020 disrupted this program significantly. The aim study is to investigate prevalence distribution HPV genotypes among population undergoing during period. From January 2017 December 2022, Peking Union Medical College Hospital gathered 45,496 swabs from individuals screening. These samples were...
The scope of laparoscopic surgery has expanded to encompass hepatic resections, specifically hemangioma. most serious intraoperative complication is bleeding, often requiring laparotomy. Because risk factors associated with such massive blood loss have not been well evaluated, the intent this retrospective study was analyze these resection hemangiomas.From June 1, 2011 January 31, 2021, 140 consecutive patients underwent for hemangioma in our hospital. According quantity loss, they were...
ADVERTISEMENT RETURN TO ISSUEPREVCorrectionORIGINAL ARTICLEThis notice is a correctionConcise Syntheses of the Abyssinones and Discovery New Inhibitors Prostate Cancer MMP-2 ExpressionRebecca L. Farmer, Margaret M. Biddle, Antoinette E. Nibbs, Xiaoke Huang, Li Xu, Raymond C. Bergan, Karl A. Scheidt*Cite this: ACS Med. Chem. Lett. 2011, 2, 3, 257Publication Date (Web):January 12, 2011Publication History Published online12 January 2011Published inissue 10 March...