A5102792018- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer Research and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Autoimmune and Inflammatory Disorders
- Gallbladder and Bile Duct Disorders
- Cancer Cells and Metastasis
- Psoriasis: Treatment and Pathogenesis
- Cancer-related gene regulation
- Lung Cancer Research Studies
- Circular RNAs in diseases
- Gastric Cancer Management and Outcomes
- Neuroblastoma Research and Treatments
- Cytokine Signaling Pathways and Interactions
- Toxin Mechanisms and Immunotoxins
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Inflammasome and immune disorders
- Metastasis and carcinoma case studies
- Esophageal and GI Pathology
- Ferroptosis and cancer prognosis
- Gastrointestinal disorders and treatments
Shenyang Medical College
2025
Huazhong University of Science and Technology
2016-2025
Tongji Hospital
2016-2025
Guangxi University
2025
Renji Hospital
2023
Shanghai Jiao Tong University
2023
Shanghai Cancer Institute
2023
American Society of Anesthesiologists
2023
Ratio
2023
Fistula Foundation
2023
Abstract Background Pancreatic cancer is one of the most lethal human cancers. N 6 -methyladenosine (m A), a common eukaryotic mRNA modification, plays critical roles in both physiological and pathological processes. However, its role pancreatic remains elusive. Methods LC/MS was used to profile m A levels normal tissues. Bioinformatics analysis, real-time PCR, immunohistochemistry, western blotting were identify regulators cancer. The biological effects methyltransferase-like 14 (METTL14),...
Objective: The aim of the study was to analyze outcomes patients who have undergone laparoscopic pancreaticoduodenectomy (LPD) in China. Summary Background Data: LPD is being increasingly used worldwide, but an extensive, detailed, systematic, multicenter analysis procedure has not been performed. Methods: We retrospectively reviewed 1029 consecutive had between January 2010 and August 2016 Univariate multivariate analyses patient demographics, changes outcome over time, technical learning...
Abstract Ferroptosis, an iron‐dependent form of regulated cell death driven by excessive accumulation lipid peroxides, has become a promising strategy in cancer treatment. Cancer cells exploit antioxidant proteins, including Ferroptosis Suppressor Protein 1 (FSP1), to prevent ferroptosis. In this study, it is found that the E3 ubiquitin ligase TRIM21 bound FSP1 and mediated its ubiquitination on K322 K366 residues via K63 linkage, which essential for membrane translocation ferroptosis...
Skin wound healing is a complex physiological process that involves many different cell types and signaling molecules. In traditional Chinese medicine, A. membranaceus Panax notoginseng are commonly used together for the treatment of injury their significant efficacy. The application new materials may make -P. (AP) play better curative effect. this study, we fabricated Carboxymethyl chitosan-Sodium alginate hydrogel loaded with extract Astragalus - P. (APCS), which showed favorable...
With a 5-year survival rate of approximately 10%, pancreatic ductal adenocarcinoma (PDAC) is one the most lethal solid malignancies in humans. A poor understanding underlying biology has resulted lack effective targeted therapeutic strategies. Tissue microarray and bioinformatics analyses have revealed that downstream transcriptional coactivator Hippo pathway, with PDZ-binding motif (TAZ), might be target PDAC. Since pharmacological inhibition TAZ challenging, we performed unbiased...
Cancer stem cells (CSCs)/tumor-initiating have been defined as a subset of tumor responsible for initiating and sustaining development. Emerging evidence strongly supports the existence CSCs in various solid tumors, but they not yet identified human gallbladder carcinomas (GBC). In this study, we primary GBC cell line GBC-SD using surface markers CD44 CD133. The percentages CD44+CD133+ were 1.76-3.05% tumors 40.29% cells. These showed properties, including self-renewal, differentiation...
// Xiuhui Shi 1, * , Hang Zhang Min Wang Xiaodong Xu 1 Yan Zhao Ruizhi He Zhou Li Feng Peng Chengjian Ming Shen Xin Xingjun Guo and Renyi Qin Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Medical College, Huazhong University Science Technology, Wuhan, China These authors have contributed equally to this study Correspondence to: Qin, email: ryqin@tjh.tjmu.edu.cn Guo, xjguo@tjh.tjmu.edu.cn Keywords: long noncoding RNA, AFAP1-AS1, cholangiocarcinoma, proliferation,...
Background: Textbook outcome (TO) is a composite measure for surgical quality assessment. The aim of this study was to assess TO following laparoscopic pancreaticoduodenectomy (LPD), identify factors independently associated with achieving TO, and analyze hospital variations regarding the after case-mix adjustment. Methods: This multicenter cohort retrospectively analyzed 1029 consecutive patients undergoing LPD at 16 high-volume pancreatic centers in China from January 2010 August 2016....
Abstract Hepatocellular carcinoma is a primary liver cancer, characterised by diverse etiology, late diagnoses, and poor prognosis. mostly resistant to current treatment options, therefore, identification of more effective druggable therapeutic targets needed. We found microRNA miR-20a-5p upregulated during mouse tumor progression in human hepatocellular patients. In this study, we elucidated the potential targeting oncogenic miR-20a-5p, vivo, xenograft model two transgenic models via...
We sought to find new immune-based treatments for pancreatic cancer.We detected IL18 expression in plasma and specimens from patients with cancer. then investigated whether had a therapeutic effect cancer vitro vivo any underlying mechanisms.Higher was associated longer overall survival (OS), but higher tissues shorter OS increased invasion metastasis. Recombinant alone no antitumor the syngeneic mice orthotopically transplanted tumors promoted immunocompromised mice; it also facilitated...
Objective: The aim of this trial was to evaluate the oncological superiority laparoscopic versus open distal pancreatectomy in left-sided pancreatic cancer. Background: efficacy cancer remains controversial. Methods: We performed a multi-center, open-label, randomized controlled patients. Candidates were recruited from six centers China, and randomly assigned receive either LDP or ODP. primary outcome recurrence-free survival, secondary outcomes overall R0 resection rate, retrieved lymph...
BACKGROUND Non-alcoholic fatty liver disease (NAFLD) is characterized by the accumulation of fat in individuals who do not consume alcohol. Several risk factors influencing onset NAFLD after laparoscopic pancreaticoduodenectomy (LPD) have been identified. This study investigated associated with development duodenum-preserving pancreatic total head resection (LDPPHRt) and LPD. AIM To compare effects LDPPHRt LPD on postoperative NAFLD. METHODS retrospective cohort included 59 patients were...
Pancreatic cancer is the seventh leading cause of death worldwide, which demonstrated with remarkable resistance to radiotherapy and chemotherapy. The identification prognosis signature novel prognostic markers will facilitate patient stratification an individualized precision therapy strategy. In this study, TCGA-PAAD was used screen E3 ubiquitin ligases establish signatures, GEO database verify accuracy signatures. Functional analysis, in vitro experiments clinical cohort studies were...
Abstract Cholangiocarcinoma (CCA) is a cancer type with high postoperative relapse rates and poor long-term survival largely due to tumor invasion, distant metastasis, multidrug resistance. Deregulated microRNAs (miRNAs) are implicated in several types including CCA. The specific roles of the miRNA let-7c cholangiocarcinoma not known need be further elucidated. In our translational study we show that microRNA expression was significantly downregulated human tissues when compared adjacent...
Pancreatic ductal adenocarcinoma is prone to metastasis, resulting in short survival and low quality of life. LncRNAs are pivotal orchestrators that participate various tumor progress. The underlying role mechanism lncRNA FAM83H-AS1 still unknown PDAC progression.To address this issue, firstly, we profiled analyzed the aberrant expression TCGA database identified as most effective one promoting migration pancreatic cancer cells. Then, levels patient's serum, tissues cells were detected using...
Abstract Objective The aim of this study was to compare the short- and long-term outcomes laparoscopic surgery (LS) open (OP) for perihilar cholangiocarcinoma (PHC) using a large real-world dataset in China. Methods Data patients with PHC who underwent LS OP from January 2013 October 2018, across 10 centers China, were extracted medical records. A comparative analysis performed before after propensity score matching (PSM) groups within subgroups. Cox proportional hazards mixed-effects model...