A5053587654- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Tuberculosis Research and Epidemiology
- Genetic and Kidney Cyst Diseases
- Liver Disease Diagnosis and Treatment
- Mycobacterium research and diagnosis
- Vascular Malformations and Hemangiomas
- Venous Thromboembolism Diagnosis and Management
- Pediatric Hepatobiliary Diseases and Treatments
- Vascular Procedures and Complications
- RNA and protein synthesis mechanisms
- Gallbladder and Bile Duct Disorders
- Viral Infections and Vectors
- Peripheral Artery Disease Management
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Cancer, Hypoxia, and Metabolism
- Organ Transplantation Techniques and Outcomes
- Biochemical and Molecular Research
- vaccines and immunoinformatics approaches
- Cancer Research and Treatments
- Ferroptosis and cancer prognosis
- Hernia repair and management
- IgG4-Related and Inflammatory Diseases
- Acute Myocardial Infarction Research
China-Japan Friendship Hospital
2013-2025
Tianjin Hospital
2019-2025
Nanning Normal University
2025
Renji Hospital
2024
Shanghai Jiao Tong University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2010-2022
Tianjin Medical University General Hospital
2022
Peking Union Medical College Hospital
2010-2021
Beijing Ditan Hospital
2021
Fuzhou Second Hospital
2021
ABSTRACT Bats are natural hosts for a large variety of zoonotic viruses. This study aimed to describe the range bat viromes, including viruses from mammals, insects, fungi, plants, and phages, in 11 insectivorous species (216 bats total) common six provinces China. To analyze we used sequence-independent PCR amplification next-generation sequencing technology (Solexa Genome Analyzer II; Illumina). The viromes were identified by sequence similarity comparisons known mammalian included those...
As the largest group of mammalian species, which are also widely distributed all over world, rodents natural reservoirs for many diverse zoonotic viruses. A comprehensive understanding core virome should therefore assist in efforts to reduce risk future emergence or re-emergence rodent-borne pathogens.
SARS-CoV and SARS-CoV-2 have been thought to originate from bats. In this study, we screened pharyngeal anal swabs 13 064 bats collected between 2016 2021 at 703 locations across China for sarbecoviruses, covering almost all known southern hotspots, found 146 new bat sarbecoviruses. Phylogenetic analyses of available sarbecoviruses show that there are three different lineages-L1 as SARS-CoV-related CoVs (SARSr-CoVs), L2 SARS-CoV-2-related (SC2r-CoVs) novel L-R (recombinants L1 L2)-present in...
Background New therapeutic tools and molecular targets are needed for treatment of Japanese encephalitis virus (JEV) infections. JEV requires an α-1 translational frameshift to synthesize the NS1' protein required viral neuroinvasiveness. Several flavonoids have been shown possess antiviral activity in vitro against a wide spectrum viruses. To date, activities flavonol kaempferol (Kae) isoflavonoid daidzin (Dai) not described. Methodology/Principal Findings The 50% cytotoxic concentration...
In engineering practice, various types of pile foundations are commonly employed to mitigate the impact differential frost heave on structures in cold regions. However, studies how material properties influence thermo-hydro-mechanical coupling fields during freezing pile–soil system remain limited. To address this, a finite element model was developed simulate response under unidirectional conditions. The numerical simulating ground temperature field and first verified by comparison with...
Radiotherapy offers potential benefits for patients with hepatocellular carcinoma (HCC); however, the distinct role of intraoperative radiotherapy (IORT) during narrow-margin hepatectomy remains inadequately defined. This study aims at assessing safety and effectiveness IORT centrally located HCCs hepatectomy. single-center, retrospective research incorporated 659 HCCs. After applying exclusion criteria, 607 remained were divided into two groups: integrated liver resection (IORT+LR, 54...
Objective This study aims to assess the clinical value of a novel high-precision iliac vein pressure measuring device diagnose and treat compression syndrome. Methods A total 38 patients with clinically confirmed syndrome (all lesions on left side) were selected. The recovery time (time taken for return resting levels) measured in four states: rest, affected limb elevation, ankle extension flexion, gastrocnemius muscle compression. Bilateral comparisons pre- post-treatment assessments...
Hepatocellular carcinoma (HCC) with microvascular invasion (MVI) is associated high recurrence and poor survival outcomes. Although adjuvant therapies such as transcatheter arterial chemoembolization (TACE), targeted therapy, immunotherapy show potential in improving outcomes, the optimal postoperative treatment strategy remains undetermined. This study evaluates efficacy of different treatments on disease-free (DFS) overall (OS) HCC patients MVI following curative resection. A retrospective...
Abstract Background Progress in the fields of protein separation and identification technologies has accelerated research into biofluids proteomics for biomarker discovery. Urine become an ideal rich source biomarkers clinical proteomics. Here we performed a proteomic analysis urine samples from pregnant non-pregnant patients using gel electrophoresis high-resolution mass spectrometry. Furthermore, also apply non-prefractionation quantitative phosphoproteomic approach mTRAQ labeling to...
ABSTRACT The presence of heteroresistance was represented by 23% 235 fluoroquinolone (FQ)-resistant Mycobacterium tuberculosis isolates in Beijing, China, from 2008 to 2010. main mechanism FQ is due the segregation a single M. strain patients; majority with multidrug-resistant contained mixture bacterial subpopulations consisting various mutant types, suggesting that improper use major cause resistance.
Whole-genome sequencing was used to analyze the profiles of isoniazid (INH) resistance-related mutations among 188 multidrug-resistant strains Mycobacterium tuberculosis (MDR-TB) and mono-INH-resistant isolates collected in a recent Chinese national survey. Mutations were detected 18 structural genes two promoter regions 96.8% resistant isolates. There high mutation frequencies katG, inhA promoter, ahpC-oxyR regulator INH-resistant with 86.2%, 19.6%, 18.6%, respectively. Moreover, diversity...
Stacked autoencoder (SAE) provides excellent performance for image processing under sufficient training samples. However, the collection of samples is difficult in hyperspectral images. Insufficient easily make SAE overfit and limit application to hypersepctral To address this problem, a novel marginal with adaptively-spatial regularization (ARMSAE) proposed classification. First, superpixel segmentation method used divide into many homogenous regions. Then, at pretraining stage, an...
Tuberculosis is an infectious bacterial disease in humans caused primarily by Mycobacterium tuberculosis, and infects one-third of the world's total population. bovis bacillus Calmette-Guérin (BCG) vaccine has been widely used to prevent tuberculosis worldwide since 1921. Membrane proteins play important roles various cellular processes, protein-protein interactions involved these processes may provide further information about molecular organization pathways. However, membrane are...
Transcatheter arterial embolization (TAE) is a method for the treatment of liver hemangioma, but fewer studies reported long-term result.Retrospective study was conducted to hemangioma patients who received TAE. The inclusion criteria included following: period follow-up more than 5 years; and were followed up less years, surgical due enlargement tumor or severe complications collected data sex, age, size tumor, times TAE, complications, follow-up, result, whether not surgery finally...
Neutrophils have been recognized to play an important role in the pathogenesis of tuberculosis recent years. Interferon-induced blood transcriptional signatures ATB are predominantly driven by neutrophils. In this study, we performed global RNA-seq on peripheral neutrophils from active patients (ATB, n=15); latent infections (LTBI, n=22); and healthy controls (HC, n=21). The results showed that greater perturbations gene expression patterns happened individuals than HC or those with LTBI, a...
Increasing evidence demonstrates that antigen-specific cellular and humoral immunity plays an indispensable role in protection against Mycobacterium tuberculosis infection. Antigen is a key element the development of successful diagnostic method vaccine. However, few antigens are available, systemic study on M. ORFeome-based antigen screening still lacking. In current study, genome-wide examination was conducted high-throughput encoding proteins novel were identified via comprehensive...