A5028958188- HIV Research and Treatment
- Viral gastroenteritis research and epidemiology
- Viral Infections and Vectors
- Animal Virus Infections Studies
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Bacteriophages and microbial interactions
- SARS-CoV-2 and COVID-19 Research
- Cancer-related molecular mechanisms research
- Plant Physiology and Cultivation Studies
- Reproductive biology and impacts on aquatic species
- Respiratory viral infections research
- Herpesvirus Infections and Treatments
- Aquaculture Nutrition and Growth
- Fish Biology and Ecology Studies
- Vector-Borne Animal Diseases
- MicroRNA in disease regulation
- Animal Disease Management and Epidemiology
- Plant Virus Research Studies
- Postharvest Quality and Shelf Life Management
- Attention Deficit Hyperactivity Disorder
- Genomics and Phylogenetic Studies
- Circular RNAs in diseases
- Genetic Mapping and Diversity in Plants and Animals
- Fungal Biology and Applications
Shandong First Medical University
2013-2025
Shandong Tumor Hospital
2013-2025
Southwest University
2017-2025
Gannan Normal University
2025
Jiangxi Agricultural University
2025
Citrus Research Institute
2025
Sansure Biotech (China)
2025
Guangzhou Blood Center
2024
Shanghai Jiao Tong University
2012-2024
Chinese Center For Disease Control and Prevention
2007-2024
ABSTRACT Bats are natural hosts for a large variety of zoonotic viruses. This study aimed to describe the range bat viromes, including viruses from mammals, insects, fungi, plants, and phages, in 11 insectivorous species (216 bats total) common six provinces China. To analyze we used sequence-independent PCR amplification next-generation sequencing technology (Solexa Genome Analyzer II; Illumina). The viromes were identified by sequence similarity comparisons known mammalian included those...
Rodents represent around 43% of all mammalian species, are widely distributed, and the natural reservoirs a diverse group zoonotic viruses, including hantaviruses, Lassa tick-borne encephalitis viruses. Thus, analyzing viral diversity harbored by rodents could assist efforts to predict reduce risk future emergence diseases.We used next-generation sequencing metagenomic analysis survey for range families in other small animals orders Rodentia, Lagomorpha, Soricomorpha China. We sampled 3,055...
Abstract Shotgun metagenomics has become a pivotal technology in microbiome research, enabling in‐depth analysis of microbial communities at both the high‐resolution taxonomic and functional levels. This approach provides valuable insights diversity, interactions, their roles health disease. However, complexity data processing need for reproducibility pose significant challenges to researchers. To address these challenges, we developed EasyMetagenome, user‐friendly pipeline that supports...
Multidrug and toxic compound extrusion (MATE) family is an important group of the multidrug efflux transporters that extrude organic compounds, transporting a broad range substrates such as acids, plant hormones secondary metabolites. However, genome-wide analysis MATE in species limited no studies have been reported soybean.A total 117 genes encoding were identified from whole genome sequence soybean (Glycine max), which denominated GmMATE1 - GmMATE117. These GmMATE unevenly localized on...
Detection of pathogens by plants is mediated intracellular nucleotide-binding site leucine-rich repeat (NLR) receptor proteins. NLR proteins are defined their stereotypical multidomain structure: an N-terminal Toll-interleukin (TIR) or coiled-coil (CC) domain, a central (NB) and C-terminal (LRR). The plant innate immune system contains limited repertoire that functions to recognize all potential pathogens. We isolated Response the bacterial type III effector protein HopBA1 (RBA1), gene...
To clarify the evolutionary relationships among betavoronaviruses that infect bats, we analyzed samples collected during 2010-2011 from 14 insectivorous bat species in China. We identified complete genomes of 2 novel betacoronaviruses Rhinolophus pusillus and Chaerephon plicata which showed close genetic with severe acute respiratory syndrome coronaviruses.
Abstract Identification and discovery of viruses using next-generation sequencing technology is a fast-developing area with potential wide application in clinical diagnostics, public health monitoring novel virus discovery. However, tremendous sequence data from NGS study has posed great challenge both accuracy velocity for study. Here we describe VIP (“Virus Pipeline”), one-touch computational pipeline identification metagenomic data. performs the following steps to achieve its goal: (i)...
Dating back to the first epidemic among injection drug users in 1989, Yunnan province has had highest number of human immunodeficiency virus type 1 (HIV-1) infections China. However, molecular epidemiology HIV-1 not been fully characterized.Using immunoassays, we identified 103,015 accumulated cases between 1989 and 2004. We studied 321 patients representing Yunnan's 16 prefectures from four risk groups, 11 ethnic populations, ten occupations. three major circulating subtypes:...
Several lineage B betacoronaviruses termed severe acute respiratory syndrome (SARS)–like CoVs (SL-CoVs) were identified from Rhinolophus bats in China. These viruses are characterized by a set of unique accessory open reading frames (ORFs) that located between the M and N genes. Among ORFs, ORF8 is most hypervariable. In this study, ORF8s all SL-CoVs classified into 3 types, and, for first time, it was found very few sinicus have identical to human SARS-CoV. This finding provides new genetic...
Abstract Background There is a lack of studies comparing PCT, CRP and WBC levels in the differential diagnosis acute bacterial, viral, mycoplasmal respiratory tract infections. It necessary to explore correlation between above markers different types ARTI. Methods 108 children with confirmed bacterial infection were regarded as group A, 116 virus B, 122 C. The three groups detected compared. Results A significantly higher than those B C ( p < 0.05). positive rate combined detection was...
Genome-wide association studies (GWASs) have revealed a large number of genetic risk loci for many autoimmune diseases. One clear finding emerging from the published autoimmunity is that different diseases, such as psoriasis and systemic lupus erythematosus (SLE), share susceptibility loci. Our study explores additional shared by SLE in Chinese Han population.In total, 20 single nucleotide polymorphisms (SNPs) 17 previously reported 34 SNPs 24 were investigated our initial GWAS dataset....
On 26 May 2015, an imported Middle East respiratory syndrome coronavirus (MERS-CoV) was identified in Guangdong Province, China, and found to be closely related the MERS-CoV strain prevalent South Korea. The full genome of ChinaGD01 sequenced analyzed investigate epidemiology evolution circulating Korea China.
Background Mosquitoes host and transmit numerous arthropod-borne viruses (arboviruses) that cause disease in both humans animals. Effective surveillance of virome profiles mosquitoes is vital to the prevention control mosquito-borne diseases northwestern China, where epidemics occur frequently. Methods were collected Shaanxi-Gansu-Ningxia region (Shaanxi Province, Gansu Ningxia Hui Autonomous Region) China from June August 2019. Morphological methods used for taxonomic identification...
Seasonal influenza A viruses continue to pose a public health threat, and current vaccines are not sufficiently effective because of virus mutation. There is an urgent need develop broad-protection vaccine. Our team previously designed potential universal hemagglutinin (HA) sequences against seasonal H1N1 H3N2 (mH1 mH3, respectively) through mosaic strategy. In this study, we construct DNA by linking the antigens mH1 mH3 via internal ribosome entry sites then wrap with deoxycholic...
Abstract Polyrotaxanes (PRs) have attracted significant research attention due to their unique topological structures and high degrees of conformational freedom. Herein, we take advantage an oligo[2]rotaxane construct a novel class dynamically cross‐linked rotaxane network (DCRN) mediated by metal‐coordination. The skeleton offers several distinct advantages: In addition retaining the merits traditional polymer backbones, ordered intramolecular motion [2]rotaxane motifs introduced dangling...
Conidia are considered to be the primary cause of infections by Trichophyton rubrum.We have developed a cDNA microarray containing 10250 ESTs monitor transcriptional strategy conidial germination. A total 1561 genes that had their expression levels specially altered in process were obtained and hierarchically clustered with respect profiles. By functional analysis, we provided global view an important biological system related germination, including characterization pattern gene at...
Yunnan has been severely affected by HIV/AIDS in China. Recently, the reported prevalence of HIV-1 among men who have sex with (MSM) was high To monitor dynamic epidemic MSM, genetic characteristics and transmitted drug resistance (TDR) were investigated.Blood samples from 131 newly diagnosed MSM continuously collected at fixed sites January 2010 to December 2012 Kunming City, Province. Partial gag, pol env genes sequenced. Phylogenetic, evolutionary genotypic analyses performed.Multiple...