A5100458236- Virus-based gene therapy research
- Herpesvirus Infections and Treatments
- Tuberculosis Research and Epidemiology
- Immunotherapy and Immune Responses
- Poxvirus research and outbreaks
- Reproductive tract infections research
- Viral gastroenteritis research and epidemiology
- Animal Disease Management and Epidemiology
- vaccines and immunoinformatics approaches
- Bacterial Infections and Vaccines
- Animal Virus Infections Studies
- Immune responses and vaccinations
- Syphilis Diagnosis and Treatment
- Mycobacterium research and diagnosis
- interferon and immune responses
- Leprosy Research and Treatment
- Zoonotic diseases and public health
- Virology and Viral Diseases
- Viral Infections and Vectors
University of California, Davis
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2021
Shenzhen Third People’s Hospital
2015-2018
Guangdong Medical College
2015-2018
University of Hong Kong
2018
The narrow host range of Mycobacterium leprae and the fact that it is refractory to growth in culture has limited research on biologic understanding leprosy. Host genetic factors are thought influence susceptibility infection as well disease progression.We performed a two-stage genomewide association study by genotyping 706 patients 1225 controls using Human610-Quad BeadChip (Illumina). We then tested three independent replication sets for an between presence leprosy 93 single-nucleotide...
Rodents represent around 43% of all mammalian species, are widely distributed, and the natural reservoirs a diverse group zoonotic viruses, including hantaviruses, Lassa tick-borne encephalitis viruses. Thus, analyzing viral diversity harbored by rodents could assist efforts to predict reduce risk future emergence diseases.We used next-generation sequencing metagenomic analysis survey for range families in other small animals orders Rodentia, Lagomorpha, Soricomorpha China. We sampled 3,055...
Several bat species act as asymptomatic reservoirs for many viruses that are highly pathogenic in other mammals. Here, we have characterized the functional diversification of protein kinase R (PKR), a major antiviral innate defense system. Our data indicate PKR has evolved under positive selection and undergone repeated genomic duplications bats contrast to all studied mammals single copy gene. Functional testing relationship between poxvirus antagonists revealed how an evolutionary conflict...
Myxoma virus (MYXV) causes localized cutaneous fibromas in its natural hosts, tapeti and brush rabbits; however, the European rabbit, MYXV lethal disease myxomatosis. Currently, molecular mechanisms underlying this increased virulence after cross-species transmission are poorly understood. In study, we investigated interaction between M156 host protein kinase R (PKR) to determine their crosstalk with proinflammatory nuclear factor kappa B (NF-κB) pathway. Our results demonstrated that...
Abstract The antiviral protein kinase R (PKR) is activated by viral double-stranded RNA and phosphorylates translation initiation factor eIF2α, thereby inhibiting virus replication. Most poxviruses contain two PKR inhibitors, called E3 K3 in vaccinia (VACV), which are determinants of host range. prevailing model for function that it inhibits through the non-specific sequestration (ds) RNA. Our data revealed Syrian hamster was resistant to E3, at odds with model. However, still sensitive...
Abstract: We here described a ceftriaxone-resistant Neisseria gonorrhoeae FC428 clone (YL201) with moderate-level resistance to azithromycin in Shenzhen, South China 2020. The NG-STAR type of YL201 is ST2238, containing mosaic penA -60.001 allele, which typical characteristic clone. harbours four copies the 23S rRNA C2611T mutation, conferring azithromycin. MLST ST1600, identical two N. clones identified Hangzhou. Genome-wide phylogeny analysis demonstrates that clustered other from Hangzhou...
ABSTRACT The antiviral protein kinase R (PKR) is activated by viral double-stranded RNA and phosphorylates translation initiation factor eIF2α, thereby inhibiting virus replication. Most poxviruses contain two PKR inhibitors, called E3 K3 in vaccinia (VACV), which are determinants of host range. prevailing model for function that it inhibits through the non-specific sequestration (ds) RNA. Our data revealed Syrian hamster was resistant to E3, at odds with model. However, still sensitive...
Abstract Background: Mycobacterium tuberculosis (M.tb.) pandemic continues to grow together with serious issues of increasing drug resistance, HIV co-infection and mortality. Since the existing BCG vaccine does not provide significant protection in adults, novel protective strategies should be explored urgency. Methods: DNA vaccines that express TB antigens Ag85B, ESAT-6, Rv2660c fusion BER, were investigated BALB/c mice intramuscularly electroporation (EP). Immunogenicity efficacy...