A5029907408- Vector-borne infectious diseases
- Genomics and Phylogenetic Studies
- Insect symbiosis and bacterial influences
- Parasite Biology and Host Interactions
- Chromosomal and Genetic Variations
- Plant Reproductive Biology
- Parasitic Infections and Diagnostics
- Viral Infections and Vectors
- Bacteriophages and microbial interactions
- Genetic diversity and population structure
- Molecular Biology Techniques and Applications
- RNA and protein synthesis mechanisms
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Vibrio bacteria research studies
- Insect-Plant Interactions and Control
- Animal Virus Infections Studies
- Educational Methods and Media Use
- Bat Biology and Ecology Studies
- Vector-Borne Animal Diseases
- COVID-19 Pandemic Impacts
- Evolutionary Game Theory and Cooperation
- Evolution and Genetic Dynamics
- RNA modifications and cancer
- Leptospirosis research and findings
- Gene expression and cancer classification
Centre National de la Recherche Scientifique
2011-2025
Université Claude Bernard Lyon 1
2015-2025
Laboratoire de Biométrie et Biologie Evolutive
2015-2025
VetAgro Sup
2022
Cadi Ayyad University
2022
Aix-Marseille Université
2012
Inserm
2012
Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes
2012
Institut de Recherche pour le Développement
2011-2012
Institut de Neurobiologie de la Méditerranée
2011
In many species with sex chromosomes, the Y is a tiny chromosome. However, dioecious plant Silene latifolia has giant ~550-megabase chromosome, which remained unsequenced so far. We used long- and short-read hybrid approach to obtain high-quality male genome. Comparative analysis of chromosomes their homologs in outgroups showed that highly rearranged degenerated. Recombination suppression between X extended several steps triggered massive accumulation repeats on as well nonrecombining...
Here, we sequenced the 5,419,609 bp circular genome of an Enterobacter aerogenes clinical isolate that killed a patient and was resistant to almost all current antibiotics (except gentamicin) commonly used treat Enterobacterial infections, including colistin. Genomic phylogenetic analyses explain discrepancies this bacterium show its core originates from another genus, Klebsiella. Atypical characteristics (i.e., motility, presence ornithine decarboxylase, lack urease activity) are attributed...
SNPs (Single Nucleotide Polymorphisms) are genetic markers whose precise identification is a prerequisite for association studies. Methods to identify them currently well developed model species, but rely on the availability of (good) reference genome, and therefore cannot be applied non-model species. They also mostly tailored whole genome (re-)sequencing experiments, whereas in many cases, transcriptome sequencing can used as cheaper alternative which already enables located transcribed...
Several bat species act as asymptomatic reservoirs for many viruses that are highly pathogenic in other mammals. Here, we have characterized the functional diversification of protein kinase R (PKR), a major antiviral innate defense system. Our data indicate PKR has evolved under positive selection and undergone repeated genomic duplications bats contrast to all studied mammals single copy gene. Functional testing relationship between poxvirus antagonists revealed how an evolutionary conflict...
Orientia tsutsugamushi is the causal agent of scrub typhus, a public health problem in Asia-Pacific region and life-threatening disease. O. an obligate intracellular bacterium that mainly infects endothelial cells. We demonstrated here also replicated monocytes isolated from healthy donors. In addition, altered expression more than 4,500 genes, as by microarray analysis. The type I interferon, interferon-stimulated genes associated with M1 polarization macrophages was significantly...
Background The diagnostic and prognostic assessments of infective endocarditis (IE) are challenging. To investigate the host response during IE to identify potential biomarkers, we determined circulating gene expression profile using whole genome microarray analysis. Methods Results A transcriptomic case-control study was performed on blood samples from patients with native valve (n = 39), excluded after an initial suspicion 10) at patient's admission, age-matched healthy controls 10). Whole...
ABSTRACT Coxiella burnetii 109, with a 2.03-Mb genome, is doxycycline-resistant human isolate that was isolated from the cardiac valve of German male patient Q fever endocarditis who died during course treatment due to bacterium's resistance doxycycline. This new genome can be useful for future comparative genomic or studies.
In horizontally transmitted symbioses, structural, biochemical, and molecular features both facilitate host colonization by specific symbionts mediate their persistent carriage. the association between squid Euprymna scolopes its luminous bacterial partner Vibrio fischeri, interact with two epithelial fields; they (i) transiently superficial ciliated field that potentiates regresses within days of (ii) persistently cells line internal crypts, whose ultrastructure changes in response to...
The Coxiellaceae family is composed of five genera showing lifestyles ranging from free-living to symbiosis. Among them, Coxiella burnetii a well-known pathogen causing Q fever in humans. This bacterium presents both intracellular (parasitic) and environmental (resistant) forms. Recently, several genomes have been reported, among which come mutualistic symbionts ticks, termed Coxiella-like endosymbionts. We sequenced two new Coxiella-LE Dermacentor marginatus (CLEDm) Ornithodoros maritimus...
Abstract In some species, the Y is a tiny chromosome but dioecious plant Silene latifolia has giant ∼550 Mb chromosome, which remained unsequenced so far. Here we used hybrid approach to obtain high-quality male S. genome. Using mutants for sexual phenotype, identified candidate sex-determining genes on Y. Comparative analysis of sex chromosomes with outgroups showed surprisingly rearranged and degenerated ∼11 MY-old system. Recombination suppression between X extended in stepwise process,...
Abstract Foraging behaviours encompass strategies to locate resources and exploit them. In many taxa, these are driven by a major gene called for, but the mechanisms of regulation vary between species. parasitoid wasp Venturia canescens , sexual asexual populations coexist in sympatry differ life‐history traits, physiology behaviours, which could impact their foraging strategies. Here, we explored molecular bases underpinning divergence testing two mutually nonexclusive hypotheses: first,...
Abstract Several bat species act as asymptomatic reservoirs for many viruses that are instead highly pathogenic in other mammals. Here, we have characterized the functional diversification of Protein kinase R (PKR), a major antiviral innate defense system. Our data indicate PKR has evolved under positive selection and undergone repeated genomic duplications bats, contrast to all studied mammals possess single copy gene. Functional testing relationship between poxvirus antagonists revealed...
This paper aims to investigate how students can maximize and develop their skills for reading short passages. It also explain evaluate students’ views of experiences with such To meet these objectives, the study adopts a quantitative approach. Data are collected from 540 studying English in second semester through an online questionnaire. The indicates that most participants intensely interested developing shows although understand meaning ‘some’ words selected passages, they cannot...
Abstract SNPs (Single Nucleotide Polymorphisms) are genetic markers whose precise identification is a prerequisite for association studies. Methods to identify them currently well developed model species, but rely on the availability of (good) reference genome, and therefore cannot be applied non-model species. They also mostly tailored whole genome (re-)sequencing experiments, whereas in many cases, transcriptome sequencing can used as cheaper alternative which already enables located...
Abstract In the context of current extinction crisis, identifying new conservation units is pivotal to development sound measures, especially in highly threatened taxa such as felids. Corsican wildcats are known by people since a very long time but have been little studied. Meaningful information about their phylogenetic position lacking. We used ddRADseq genotype phenotypically homogenous at 3671 genome‐wide SNPs and reported for first genetic identity. compared this genomic domestic cats...
Abstract Sexual dimorphism is widespread among species with separate sexes and its extent thought to be governed by the differential expression of thousands genes between males females (known as Sex-Biased Genes, hereafter SBGs). SBGs have been studied in numerous species, but rarely a comparative way, which curtails our understanding their evolution, especially during multiple independent transitions sexes. We sequenced transcriptomes nine dioecious two gynodioecious (separate...
Abstract The Coxiellaceae family is composed of five genera showing lifestyles ranging from free-living to symbiosis. Among them, Coxiella burnetii a well-known pathogen causing Q fever in humans. This bacterium presents both intracellular (parasitic) and environmental (resistant) forms. Recently, several genomes have been reported, among which come mutualistic symbionts ticks, termed -like endosymbionts. We sequenced two new -LE Dermacentor marginatus (CLEDm) Ornithodoros maritimus...