A5049241523- Viral Infections and Vectors
- Burkholderia infections and melioidosis
- Mosquito-borne diseases and control
- Leptospirosis research and findings
- Vector-borne infectious diseases
- Malaria Research and Control
- Mycobacterium research and diagnosis
- Antibiotic Resistance in Bacteria
- Plant Pathogenic Bacteria Studies
- Tuberculosis Research and Epidemiology
- Computational Drug Discovery Methods
- Parasitic Infections and Diagnostics
- Amoebic Infections and Treatments
- Brucella: diagnosis, epidemiology, treatment
- Parasites and Host Interactions
- Immunodeficiency and Autoimmune Disorders
- Veterinary medicine and infectious diseases
- Infections and bacterial resistance
- Viral Infections and Outbreaks Research
- Immune Cell Function and Interaction
- Helminth infection and control
- SARS-CoV-2 and COVID-19 Research
- Parasite Biology and Host Interactions
- Chemical Looping and Thermochemical Processes
- COVID-19 Clinical Research Studies
Mahidol University
2016-2025
Siriraj Hospital
2015-2024
Khon Kaen University
1999-2014
National Institute of Infectious Diseases
2014
Churchill Hospital
2009
Wellcome Trust
2009
Mahidol Oxford Tropical Medicine Research Unit
1992-2008
Udon Thani Hospital
2006
Hospital for Tropical Diseases
2005
Kanchanaburi Rajabhat University
2003
Autoantibodies against interferon-γ are associated with severe disseminated opportunistic infection, but their importance and prevalence unknown.We enrolled 203 persons from sites in Thailand Taiwan five groups: 52 patients disseminated, rapidly or slowly growing, nontuberculous mycobacterial infection (group 1); 45 another without 2); 9 tuberculosis 3); 49 pulmonary 4); 48 healthy controls 5). Clinical histories were recorded, blood specimens obtained.Patients groups 1 2 had CD4+...
Abstract Cryptococcal meningitis has been described in immunocompromised patients, as well those for whom no immune defect identified. GM-CSF regulates the function of phagocytes and pulmonary alveolar macrophages, critical elements cryptococcal control. We performed clinical histories, immunological evaluation, anticytokine autoantibody screening four current patients with identified tested 103 archived plasma/cerebrospinal fluid samples from meningitis. assessed ability anti–GM-CSF...
A case-control study was conducted in four hospitals northeastern Thailand to identify risk factors for melioidosis and bacteremic melioidosis. Cases were patients with culture-proven melioidosis, there two types of controls (those infections, i.e., community-acquired septicemia caused by other bacteria, those without infection, randomly selected admitted noninfectious diseases the same hospitals). Demographic data, clinical presentations, suspected analyzed. Diabetes mellitus, preexisting...
Melioidosis, or infection with Pseudomonas pseudoniallei is an important cause of morbidity and mortality in South East Asia Northern Australia. The epidemiology melioidosis Ubon Ratchatani, Northeast Thailand was studied over a 5-year period from 1987 to 1991. Rates and, when possible, the risks developing were calculated. numerator number culture-proven cases seen 1000-bed referral hospital province. denominators obtained population census, survey Health, Welfare Use Traditional Medicine,...
Relapse in Melioidosis: Incidence and Risk Factors Get access W. Chaowagul, Chaowagul Search for other works by this author on: Oxford Academic PubMed Google Scholar Y. Suputtamongkol, Suputtamongkol Reprints or correspondence: Dr. Suputtarnongkol, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Rd., Bangkok 10400, Thailand. D. A. B. Dance, Dance Rajchanuvong, Rajchanuvong J. Pattara, Pattara N. White The Journal Infectious Diseases, Volume 168, Issue 5, November 1993, Pages...
Background. We observed that some patients with clinical leptospirosis supported by positive results of rapid tests were negative for on the basis our diagnostic gold standard, which involves isolation Leptospira species from blood culture and/or a result microscopic agglutination test (MAT). hypothesized reference standard was imperfect and used statistical modeling to investigate this hypothesis. Methods. Data 1652 suspected recruited during three observational studies one randomized...
An open, prospective, randomized, comparative treatment trial was conducted to compare the therapeutic efficacy of high-dose intravenous imipenem and ceftazidime for acute severe melioidosis. Adult Thai patients with suspected acute, melioidosis were randomized receive either imipenem, at a dosage 50 mg/(kg z d), or ceftazidime, 120 minimum 10 days. The main outcome measures death failure. Of 296 enrolled, 214 had culture-confirmed melioidosis, 132 (61.7%) them positive blood cultures....
BackgroundA sustained outbreak of leptospirosis occurred in northeast Thailand between 1999 and 2003, the basis for which was unknown.Methods FindingsA prospective study conducted 2000 2005 to identify patients with presenting Udon Thani Hospital Thailand, isolate causative organisms from blood. A multilocus sequence typing scheme developed genotype these pathogenic Leptospira. Additional performed Leptospira isolated human cases other Thai provinces over same period, rodents captured during...
Leptospirosis is an important cause of fever in the rural tropics. Since 1996, there has been a marked increase incidence leptospirosis northeastern Thailand. Although generally susceptible to antibiotics, no consensus regarding optimal treatment for severe leptospirosis.An open-label, randomized comparison parenteral cefotaxime, penicillin G sodium (hereafter known as "penicillin G"), and doxycycline suspected was conducted. The study involved 540 patients admitted 4 hospitals Thailand.A...
The adult patients who, between July 2001 and June 2002, presented at any of five hospitals in Thailand with acute febrile illness the absence an obvious focus infection were prospectively investigated. Blood samples taken from all checked for aerobic bacteria leptospires by culture. In addition, least two serum collected different times (on admission 2–4 weeks post-discharge) each patient tested, serological tests, evidence leptospirosis, rickettsioses, dengue influenza. 845 investigated,...
Background Leptospirosis is the most common bacterial zoonoses and has been identified as an important emerging global public health problem in Southeast Asia. Rodents are reservoirs for human leptospirosis, but epidemiological data lacking. Methodology/Principal Findings We sampled rodents living different habitats from seven localities distributed across Asia (Thailand, Lao PDR Cambodia), between 2009 to 2010. Human isolates were also obtained close where sampled. The prevalence of...
ABSTRACT Leptospirosis and scrub typhus are important causes of acute fever in Southeast Asia. Options for empirical therapy include doxycycline azithromycin, but it is unclear whether their efficacies equivalent. We conducted a multicenter, open, randomized controlled trial with adult patients presenting (<15 days), without an obvious focus infection, at four hospitals Thailand between July 2003 January 2005. Patients were randomly allocated to receive either 7-day course or 3-day...
Background Strongyloidiasis, caused by an intestinal helminth Strongyloides stercoralis, is common throughout the tropics. It remains important health problem due to autoinfection, which may result in hyperinfection and disseminated infection immunosuppressed patients, especially patients receiving chemotherapy or corticosteroid treatment. Ivermectin albendazole are effective against strongyloidiasis. However, efficacy most dosing regimen be determined. Methods A prospective, randomized,...
Despite increasing control measures, numerous parasitic and infectious diseases are emerging, re-emerging or causing recurrent outbreaks particularly in Asia the Pacific region, a hot spot of both disease emergence biodiversity at risk. We investigate how affects distribution their this taking into account socio-economics (population size, GDP, public health expenditure), geography (latitude nation size), climate (precipitation, temperature) (bird mammal species richness, forest cover, bird...
Patients suffering from serious bacterial infection present to the hospital after early inflammatory events, such as release of tumor necrosis factor (TNF), have been initiated. The role other cytokines, interleukin-8 (IL-8), a neutrophil chemoattractant and activator, in pathophysiology human sepsis is not well characterized, there are only limited data on IL-6. We studied serial concentrations TNF, IL-6 (involved acute-phase response), IL-8 plasma leukocyte levels mRNA for these cytokines...
ABSTRACT The pharmacokinetic properties of oral and intravenous artesunate (2 mg/kg body weight) were studied in 19 adult patients with acute uncomplicated Plasmodium falciparum malaria by using a randomized crossover design. A sensitive bioassay was used to measure the antimalarial activity plasma which results from its principal metabolite, dihydroartemisinin. study repeated 15 during convalescence. mean absolute bioavailability agent 61% (95% confidence interval [CI], 52 70%). absorption...
A prospective study in Thailand identified 106 patients with culture-proven leptospirosis. The accuracy of the microscopic agglutination test (MAT) predicting infecting serovar was evaluated 78/106 (74%) a diagnostic titer. MAT correctly determined 26 cases (33%), indicating that this assay is poor predictor our setting.
To identify immunological evidence of Zika virus transmission in Thailand.To undertake a preliminary serosurvey possible exposure to virus, 21 serum samples from cohort acute undifferentiated fever patients were examined for immunoreactivity Zika, Dengue, Japanese encephalitis and Chikungunya envelope antigens by Western blot analysis.Twenty the showed at least one antigens, with seven showing all antigens. Of particular note, two only antigen, no other antigens.This study presents first...
Opportunistic infections represent a serious health problem for HIV-infected people. Among enteric infections, cryptosporidiosis, severe and life-threatening diarrheal disease, is of particular importance in low economic settings where access to anti-retroviral therapy limited. Understanding transmission routes crucial establishing preventive measures, requires the use informative genotyping methods. In this study, we performed retrospective analysis Cryptosporidium species 166 stool samples...
Journal Article Serology and Carriage of Pseudomonas pseudomallei: A Prospective Study in 1000 Hospitalized Children Northeast Thailand Get access Panida Kanaphun, Kanaphun Search for other works by this author on: Oxford Academic PubMed Google Scholar Nittaya Thirawattanasuk, Thirawattanasuk Yupin Suputtamongkol, Suputtamongkol Pimjai Naigowit, Naigowit David A. B. Dance, Dance Michael D. Smith, Smith Nicholas J. White Reprints or correspondence: Dr. N. White, Faculty Tropical Medicine,...
Aims Experimental studies have suggested that constant intravenous infusion would be preferable to conventional intermittent bolus administration of beta‐lactam antibiotics for serious Gram‐negative infections. Severe melioidosis ( Burkholderia pseudomallei infection) carries a mortality over 40% despite treatment with high dose ceftazidime. The aim this study was measure the pharmacokinetic and pharmacodynamic effects continuous ceftazidime vs dosing in septicaemic melioidosis. Methods...
An open, paired, randomized, controlled trial of high-dose parenteral ceftazidime (120 mg/[kg · d]) vs. amoxicillin/clavulanate (160 for the treatment severe melioidosis was conducted in Ubon Ratchatani northeastern Thailand. Of 379 patients enrolled study, 212 (56%) had culture-proven melioidosis; 106 were each group. The overall mortality rate (47%) similar both groups. However, 4 75 surviving group compared with 16 69 switched to alternate regimen because an unsatisfactory clinical...
A randomized, open-label comparison of artesunate and quinine was conducted in 113 adults with clinically severe falciparum malaria western Thailand. Mortality 12% 22% treatment (relative risk, 0.53; 95% confidence interval, 0.23–1.26; P =.22). Multiple logistic regression analysis found admission plasma lactate level, Glasgow Coma Scale score, total serum bilirubin level to be independent risk factors for death. recovery times normalize levels were similar, but the parasite clearance time...
Disseminated intravascular coagulation (DIC) is common among patients with sepsis. Leptospirosis an important cause of sepsis in tropical areas, and pulmonary hemorrhage associated thrombocytopenia the major death, but coagulopathy severe leptospirosis has not been further characterized. The aim this study was to evaluate factors presence DIC northeast Thailand.We measured plasma concentrations fibrinogen, D-dimer, thrombin-antithrombin III complexes, prothrombin fragment 1,2 evaluated score...