A5070410197- HIV/AIDS drug development and treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Burkholderia infections and melioidosis
- Fungal Infections and Studies
- HIV Research and Treatment
- Antifungal resistance and susceptibility
- Antibiotic Resistance in Bacteria
- Mycobacterium research and diagnosis
- HIV/AIDS Research and Interventions
- Infectious Diseases and Tuberculosis
- HIV-related health complications and treatments
- Antibiotics Pharmacokinetics and Efficacy
- Infectious Diseases and Mycology
- Antibiotic Use and Resistance
- Nosocomial Infections in ICU
- Drug-Induced Adverse Reactions
- Pneumonia and Respiratory Infections
- Immunodeficiency and Autoimmune Disorders
- Vibrio bacteria research studies
- Orthopedic Infections and Treatments
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Nephrotoxicity and Medicinal Plants
- Cytomegalovirus and herpesvirus research
- Urinary Tract Infections Management
Khon Kaen University
2012-2024
Songklanagarind Hospital
2005-2023
Mahidol University
1999-2012
Tufts University
2005
Tufts Medical Center
2005
University of Rochester
2000
Siriraj Hospital
1999
Surin Hospital
1999
Autoantibodies against interferon-γ are associated with severe disseminated opportunistic infection, but their importance and prevalence unknown.We enrolled 203 persons from sites in Thailand Taiwan five groups: 52 patients disseminated, rapidly or slowly growing, nontuberculous mycobacterial infection (group 1); 45 another without 2); 9 tuberculosis 3); 49 pulmonary 4); 48 healthy controls 5). Clinical histories were recorded, blood specimens obtained.Patients groups 1 2 had CD4+...
A case-control study was conducted in four hospitals northeastern Thailand to identify risk factors for melioidosis and bacteremic melioidosis. Cases were patients with culture-proven melioidosis, there two types of controls (those infections, i.e., community-acquired septicemia caused by other bacteria, those without infection, randomly selected admitted noninfectious diseases the same hospitals). Demographic data, clinical presentations, suspected analyzed. Diabetes mellitus, preexisting...
Pythiosis is an emerging and life-threatening infectious disease in humans animals that caused by the pathogenic oomycete Pythium insidiosum. Human pythiosis found mostly Thailand, although has been increasingly reported worldwide. Clinical information on human limited, health care professionals are unfamiliar with disease, leading to underdiagnosis, delayed treatment, poor prognosis.To retrospectively study clinical epidemiological features of pythiosis, we analyzed data from patients...
Objective: Nevirapine is widely prescribed for HIV-1 infection. We characterized relationships between nevirapine-associated cutaneous and hepatic adverse events genetic variants among HIV-infected adults. Design: retrospectively identified cases controls. Cases experienced symptomatic severe (grade III/IV) and/or within 8 weeks of initiating nevirapine. Controls did not experience during more than 18 nevirapine therapy. Methods: controls were matched 1: 2 on baseline CD4 T-cell count, sex,...
Melioidosis, an infectious disease caused by the Gram-negative bacillus Burkholderia pseudomallei, is difficult to cure. Antimicrobial treatment comprises intravenous drugs for at least 10 days, followed oral 12 weeks. The standard regimen based on trial evidence trimethoprim-sulfamethoxaxole (TMP-SMX) plus doxycycline. This used in Thailand but associated with side-effects and poor adherence patients, TMP-SMX alone recommended Australia. We compared efficacy of doxycycline phase melioidosis...
Abstract Background The natural history of anti-interferon-γ (IFN-γ) autoantibody-associated immunodeficiency syndrome is not well understood. Methods Data 74 patients with anti-IFN-γ autoantibodies at Srinagarind Hospital, Thailand, were collected annually (median follow-up duration, 7.5 years). Annual data for 19 and initial 4 the US National Institutes Health 4.5 Anti-IFN-γ autoantibody levels measured in plasma samples. Results Ninety-one percent Southeast Asian descent; there was a...
A prospective, multicenter, randomized study was conducted with human immunodeficiency virus (HIV)-infected patients who were successfully treated for acute cryptococcal meningitis, receiving secondary prophylaxis, and naive antiretroviral therapy. Patients to continue or discontinue prophylaxis when the CD4 cell count had increased >100 cells/microL an undetectable HIV RNA level been sustained 3 months. At a median of 48 weeks after randomization, there no episodes meningitis in either group.
Disseminated nontuberculous mycobacterial (NTM) infection is an emerging infectious disease worldwide that occurs mostly in immunocompromised hosts. NTM uncommon persons who are not infected with human immunodeficiency virus (HIV). Recently, we described a group of non-HIV-infected Thai patients whose manifestation was previously unrecognized clinical entity characterized by chronic bilateral lymphadenopathy due to rapidly growing mycobacteria. Most the had coinfection other opportunistic...
Co-trimoxazole is a sulfonamide-containing antibiotic that effective in the treatment of several infections and for prophylaxis Pneumocystis jiroveci pneumonia. This drug has been reported as common culprit Stevens-Johnson syndrome (SJS) toxic epidermal necrolysis (TEN). Human leukocyte antigens (HLAs) play key role immunopathogenesis severe cutaneous reactions induced by drugs. study investigated association between HLA class I HLA-DRB1 polymorphisms co-trimoxazole-induced SJS/TEN Thai...
Two antibiotic regimens are used commonly in Thailand for the initial treatment of severe melioidosis: ceftazidime combination with trimethoprim-sulfamethoxazole (TMP-SMX) and monotherapy. It is not known whether TMP-SMX provides an additional benefit.Two prospective, randomized trials that compared these patients presenting acute melioidosis were started independently at tertiary care hospitals Ubon Ratchathani Khon Kaen (in northeastern Thailand), results analyzed together as a...
Most of the adverse effects reported in patients who have received COVID-19 vaccines been mild. However, possible serious are being monitored cautiously. There also a number case reports reactivation varicella zoster infection within 28 days after immunization with mRNA vaccines. A few cases viral vector and inactivated vaccination. The incidence meningitis following virus is rare. In current study, we report two male different types vaccine (inactivated vector) developed 10
Disseminated infection due to rapidly growing mycobacteria is uncommon and occurs mostly in immunocompromised patients. We report 16 cases of such with an unusual presentation seen at Srinagarind Hospital, a university hospital northeastern Thailand. The clinical features were different from those previous reports. All the patients presented chronic bilateral cervical lymphadenopathy. Twelve had mycobacterial involvement other organs (sinuses, 6 patients; lungs, 4; liver, spleen, 3; skin,...
Objectives To assess the efficacy and survival benefit of low‐dose fluconazole (400 mg weekly) for primary prophylaxis cryptococcal meningitis in patients with advanced HIV infection. Methods A prospective multicentre, randomized, double‐blind, placebo‐controlled study was carried out HIV‐infected CD4 counts <100 cells/μL. Results Of 90 enrolled, 44 received 46 placebo. The baseline characteristics were similar two groups. On an intent‐to‐treat basis, 10 cases developed, three (6.8%)...
Abstract Background In a randomized trial, Lianhuaqingwen (LHQW) capsule was effective for accelerating symptom recovery among patients with coronavirus disease 2019 (COVID-19). However, the lack of blinding and limited sample sizes decreased level clinical evidence. Objectives To evaluate efficacy safety LHQW in adults mild-to-moderate COVID-19. Methods We conducted double-blind controlled trial COVID-19 (17 sites from China, Thailand, Philippine Vietnam). Patients received standard-of-care...
Histoplasmosis and penicilliosis are infections caused by the dimorphic fungi, Histoplasma capsulatum Penicillium marneffei, respectively. The aim of this study was to compare clinical presentation, laboratory radiologic findings outcome these at Srinagarind Hospital, Khon Kaen, Thailand.The medical records patients who had positive cultures for marneffei during 1996-2002 were reviewed. data compared analyzed Chi-square Fisher's exact tests.There 32 36 with H. P. infection, respectively,...
Objectives In countries with high numbers of HIV/tuberculosis coinfection nevirapine and rifampin are used extensively. However, limited data available about whether or not can be safely coadministered without the plasma concentration falling below therapeutic levels. Methods Blood samples for determination concentrations were collected from patients using 200 mg twice daily concomitant rifampin. Bivariate multivariate linear regression models to investigate factors possibly related...
To compare the clinical and bacteriological effectiveness of intravenous (IV) ceftriaxone followed by oral cefditoren pivoxil or IV for acute pyelonephritis.A prospective randomized controlled trial patients with a presumptive diagnosis pyelonephritis was performed. Daily 2g initially given to all patients. After day 3, who satisfied criteria switch therapy were either group A (IV ceftriaxone) B (oral 400mg once daily).Eighty-two enrolled; 41 (50%) in evaluated. There no statistically...
We conducted a prospective randomized, double-blind, controlled study of cefoperazone-sulbactam (ratio, 1 : 1; cefoperazone 25 mg/kg/day) plus cotrimoxazole (trimethoprim-sulfamethoxazole [TMP-SMZ] at ratio 80 400; TMP, 8 versus ceftazidime (100 (TMP, for the treatment severe melioidosis. Of 219 patients enrolled in study, 102 (47%) had culture-proven These were assigned randomly to 2 groups, each with 50 (2 excluded). Mortality rates not significantly different between groups: 18% group 14%...
Objective To study the pharmacokinetics of indinavir/ ritonavir 400/100 mg twice daily in antiretroviral-naive patients at Srinagarind Hospital Khon Kaen, Thailand. Methods This was a steady-state, open-label pharmacokinetic 19 patients. A 12 h curve recorded after an overnight fast. Plasma levels indinavir and were determined by validated HPLC method. Virological failure defined according to most recent US Department Health Human Services guidelines as viral load above 400 copies/ml week...
ABSTRACT The oomycetous, fungus-like, aquatic organism Pythium insidiosum is the etiologic agent of pythiosis, a life-threatening infectious disease humans and animals that has been increasingly reported from tropical, subtropical, temperate countries. Human pythiosis endemic in Thailand, most patients present with arteritis, leading to limb amputation and/or death, or cornea ulcer, enucleation. Diagnosis time-consuming difficult. Radical surgery main treatment for because conventional...