Blandine Denis
A5031637030- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Bacterial biofilms and quorum sensing
- Plant Pathogens and Fungal Diseases
- Infectious Diseases and Mycology
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Mosquito-borne diseases and control
- Aging, Elder Care, and Social Issues
- Mycobacterium research and diagnosis
- COVID-19 Clinical Research Studies
- CAR-T cell therapy research
- Pneumonia and Respiratory Infections
- Burn Injury Management and Outcomes
- Health, Medicine and Society
- HIV/AIDS Research and Interventions
- Planarian Biology and Electrostimulation
- Lymphoma Diagnosis and Treatment
- Tuberculosis Research and Epidemiology
- Bacterial Identification and Susceptibility Testing
- Oral microbiology and periodontitis research
- COVID-19 epidemiological studies
- Fungal Biology and Applications
- Neutropenia and Cancer Infections
Assistance Publique – Hôpitaux de Paris
2016-2025
Hôpital Saint-Louis
2016-2025
Hôpital Fernand-Widal
2015-2025
Hôpital Lariboisière
2014-2024
Université Paris Cité
2014-2024
Centre d'Immunologie et des Maladies Infectieuses
2016-2022
Université de Technologie de Compiègne
2022
Pitié-Salpêtrière Hospital
2021
Sorbonne Université
2014-2021
Hôpital Avicenne
2019-2020
Significance Statement Although studies have found coronavirus disease 2019 (COVID-19) to be associated with high morbidity and mortality among kidney transplant recipients, risk factors for COVID-19 patients remain poorly defined. In this prospective cohort study in France, the authors enrolled 1216 patients, 66 (5%) of whom were diagnosed COVID-19. The rate overall population was 1% 24% COVID-19–positive patients. Factors that independently included non-White race comorbidities, including...
Early diagnosis and prompt initiation of specific antifungal treatment are essential for improving the prognosis mucormycosis. We aimed to assess performance serum Mucorales quantitative polymerase chain reaction (qPCR) early follow-up mucormycosis.We prospectively enrolled 232 patients with suspicion invasive mold disease, evaluated using standard imaging mycological procedures. Thirteen additional proven or probable mucormycosis were included analyze DNA load kinetics. Serum samples...
Bispecific antibodies (BsAbs) are an effective treatment used in relapsed or refractory multiple myeloma. Despite a well-tolerated safety profile, infectious events appear to be frequent clinical trials. Real-world data on epidemiology, characteristics, risk factors, and outcomes of infections patients treated with BsAb still needed. A retrospective, multicentre study BsAb-treated myeloma was performed 14 French centres from December 2020 February 2023. The primary objective describe the...
Human immunodeficiency virus (HIV)-associated primary effusion lymphoma (PEL) is a rare B-cell non-Hodgkin with poor prognosis. Lymphoma cells are always infected human herpesvirus-8 (HHV-8) and in most cases coinfected Epstein-Barr virus. In classic presentation, PEL characterized by body cavity effusions or without mass lesions. A variant only extracavitary localization has also been described. We report on large single-center series of patients the era combined antiretroviral therapy...
Invasive wound mucormycosis (IWM) is associated with an extremely poor outcome among critically ill burn patients. We describe the detection of circulating Mucorales DNA (cmDNA) for early diagnosis IWM in those patients and report potential value detecting cmDNA treatment guidance. Severely admitted to our tertiary referral center between October 2013 February 2016 were included. Retrospective plasma samples tested presence by quantitative real-time polymerase chain reaction (qPCR). Patients...
The French National Reference Center for Invasive Mycoses and Antifungals leads an active sustained nationwide surveillance program on probable proven invasive fungal diseases (IFDs) to determine their epidemiology in France. Between 2012 2018, a total of 10,886 IFDs were recorded. incidence increased slightly over time (2.16 2.36/10,000 hospitalization days, P = 0.0562) relation with increase fungemia (1.03 1.19/10,000, 0.0023), while that other remained stable. proportion ≥65-year-old...
ABSTRACT Mucorales are ubiquitous environmental molds responsible for mucormycosis in diabetic, immunocompromised, and severely burned patients. Small outbreaks of invasive wound (IWM) have already been reported burn units without extensive microbiological investigations. We faced an outbreak IWM our center investigated the clinical isolates with whole-genome sequencing (WGS) analysis. analyzed M. circinelloides from patients unit (BU1, Hôpital Saint-Louis, Paris, France) together...
Laboratory diagnosis of histoplasmosis is based on various methods, including microscopy, culture, antigen, and DNA detection Histoplasma capsulatum var. or duboisii. To improve sensitivity existing real-time quantitative PCR (qPCR) assays, we developed a new RT-qPCR assay that allows amplification whole nucleic acids spp. validated suspected cases. The limit was 20 copies, the specificity against 114 fungal isolates/species restricted to Whole 1319 prospectively collected consecutive...
"Fungal infections in patients treated with ibrutinib: two unusual cases of invasive aspergillosis and cryptococcal meningoencephalitis." Leukemia & Lymphoma, 58(12), pp. 2981–2982
To date, azoles represent the only viable option for oral treatment of invasive Candida infections, while rates azole resistance among non-albicans spp. continue to increase. The objective this sub-analysis European multicenter observational cohort study III was describe demographical and clinical characteristics requiring prolonged hospitalization solely complete intravenous (iv) antifungal (AF Tx).Each participating hospital (number eligible hospitals per country determined by population...
In a cohort of 72 consecutive virologically-suppressed patients with HIV-1 switching to long-acting cabotegravir and rilpivirine, we observed low trough concentrations 1 3 months after the first injection, significant association no oral lead-in at month [odds ratio (OR) = 6.3 [95% confidence interval (CI) 1.7–29.5], P 0.01] three (OR 5.6 CI 1.3–29.7], 0.03), high BMI 1.3 1.1–1.6], 0.007).
Abstract Background Despite advances in antifungals, Candida infections still have a high mortality rate of up to 40%. The ECMM III study Europe investigated the changing epidemiology and outcomes, highlighting need understand manage these infections. Methods In this observational cohort study, participating hospitals enrolled first ten consecutive adults with confirmed candidemia. Data collected included patient demographics, risk factors, hospital stay length (with 90-day follow-up),...
Abstract Background Burns intensive care units (BICU) have reduced mortality in burns patients, but infections and sepsis remain the leading causes of death. Infections with multidrug-resistant (MDR) bacteria increase risk death whose acquiring such is higher due to various factors, including prolonged hospitalization invasive procedures. Methods A retrospective study was performed a French BICU over eight years, analyze epidemiology factors for bloodstream (BSI). Results In total, 1402...