A5033442201- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Glaucoma and retinal disorders
- Renal Diseases and Glomerulopathies
- Hematopoietic Stem Cell Transplantation
- Neurological Complications and Syndromes
- Antifungal resistance and susceptibility
- Metabolism and Genetic Disorders
- Transplantation: Methods and Outcomes
- Traumatic Ocular and Foreign Body Injuries
- Biomedical Research and Pathophysiology
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Systemic Lupus Erythematosus Research
- COVID-19 and healthcare impacts
- Paleopathology and ancient diseases
- Infection Control and Ventilation
- Acute Kidney Injury Research
- Autoimmune and Inflammatory Disorders
- French Urban and Social Studies
- Retinal and Macular Surgery
- Biochemical and Molecular Research
- Ocular Disorders and Treatments
- Patient Safety and Medication Errors
University of Turin
2025
Hôpital Saint-Louis
2009-2020
Assistance Publique – Hôpitaux de Paris
2008-2020
Université Paris Cité
2008-2011
Délégation Paris 7
2010-2011
Service de la Santé Publique
2010
Hôpital Européen Georges-Pompidou
2008-2010
Hamad General Hospital
2009
Délégation Paris 5
2008-2009
Hôpital Européen
2008
Significance Statement Although studies have found coronavirus disease 2019 (COVID-19) to be associated with high morbidity and mortality among kidney transplant recipients, risk factors for COVID-19 patients remain poorly defined. In this prospective cohort study in France, the authors enrolled 1216 patients, 66 (5%) of whom were diagnosed COVID-19. The rate overall population was 1% 24% COVID-19–positive patients. Factors that independently included non-White race comorbidities, including...
To assess energy balance in very sick medical patients requiring prolonged acute mechanical ventilation and its possible impact on outcome, we conducted an observational study of the first 14 d intensive care unit (ICU) stay thirty-eight consecutive adult intubated at least 7 d. Exclusive enteral nutrition (EN) was started within 24 h ICU admission progressively increased, absence gastrointestinal intolerance, to recommended 125·5 kJ/kg per Calculated defined as delivered − resting...
Abstract Introduction To counter the shortage of kidney grafts in France, a non heart beating donor (NHBD) program has recently been implemented. The aim this study was to describe pilot for retrieval from "uncontrolled" NHBD meaning those whom attempts resuscitation after witnessed out-of-hospital cardiac arrest (CA) have failed (Maastricht 1 and 2), centre previously trained brain dead donors. Methods A prospective, monocentric, descriptive concerning referred our institution February 2007...
Background Morbidity and mortality conferences are a tool for evaluating care management, but they lack precise format practice in intensive units. Objectives To evaluate the feasibility usefulness of regular morbidity specific to units improving quality patient safety. Methods For 1 year, prospective study was conducted an 18-bed unit. Events analyzed included deaths unit 4 adverse events (unexpected cardiac arrest, unplanned extubation, reintubation within 24–48 hours after planned...
This prospective observational study aimed to assess the relevance of serial postoperative plasma neutrophil gelatinase-associated lipocalin (NGAL) measurements on prediction early renal transplant function.Plasma NGAL (pNGAL) was measured (Triage Test; Biosite Inc., Inverness Medical) in 41 patients scheduled for kidney transplantation from deceased or living donors, immediately before and after surgery, at 12 hr, day 1, 3, 7. A delayed graft function (DGF) defined as need dialysis during...
Allogeneic hematopoietic stem cell transplantation (HSCT) is the treatment of choice for a wide range diseases, but associated with significant risk chronic kidney disease (CKD), affecting up to 25% survivors morbidity. The causes CKD after HSCT vary between different studies. present study evaluated in patients undergoing allogeneic HSCT. We analyzed clinical course 148 who received at University Hospital St. Louis Paris 1999 and 2002 were alive 2 years without relapse. was defined as...
Background.Donation after circulatory determination of death (DCDD), formerly non-heart-beating donation and cardiac death, has been re-introduced into clinical practice in France since June 2006 as a potential solution to organ shortage, but this kidney transplantation programme is not popular yet, mainly because logistical concerns uncertainty about the long-term warm ischaemia impact on transplanted kidneys.
Background The temporal muscle fascia is the most widely used type of tissue graft in revision myringoplasty procedures. aim this study was to verify if use a cartilage may be valid alternative temporalis fascia. Tympanic reperforations are frequent after myringoplasty, especially complicated, large, or anterior perforations, so we decided compare neodrum stability two different surgical techniques. Materials and methods conducted on 42 patients who underwent carried out with overlay...
In septic patients, an unpredictable response to epinephrine may be due pharmacodynamic factors or non-linear pharmacokinetics. The purpose of this study was investigate the pharmacokinetics and its determinants in patients with shock.Thirty-eight consecutive adult shock were prospectively recruited immediately before infusion. A baseline blood sample (C0) taken assess endogenous epinephrine, norepinephrine, renin, aldosterone, plasma cortisol levels At a fixed cumulative dose adjusted body...
Abstract In 2012, an expert working group from the French Transplant Health Authority recommended use of hypothermic machine perfusion (HMP) to improve kidney preservation and transplant outcomes expanded criteria donors, deceased after brain death. This study compares HMP cold storage (CS) effects on delayed graft function (DGF) outcomes. We identified 4,316 transplants donors (2011‐2014) in France through Registry. DGF occurrence was analyzed with a logistic regression, excluding...
Purpose Expanded criteria donors (ECD) kidneys are a potential solution to organ shortage, but exhibit more delayed graft function (DGF). We conducted prospective controlled study aiming evaluate the impact of Pulsatile Perfusion Preservation (PPP) on DGF rate. Methods Inclusion were: 1) ECD definition (any brain-dead donor aged > 60 years or 50-60 with at least 2 following: history hypertension, terminal serum creatinin level ≥ 1.5 mg/dL, death resulting from cerebrovascular accident; 2)...
In Brief Background Existing data suggest that increased interstitial fibrosis may occur abnormally in renal transplants from donations after uncontrolled circulatory death (uDCD). Methods To evaluate the factors are associated with progression of and its functional impact on grafts, we compared 76 uDCD recipients 86 kidney brain at 1-year transplantation. Groups were matched for donor age, rank transplantation, absence human leukocyte antigen sensitization. Histology was performed...
Schistosomiasis is a widespread incapacitating disease, but ocular involvement relat- ively rare.The first of the few cases schistosomiasis recorded in literature was that reported Egypt by Sobhy Bey (1928).Others were Wilson (I934), Bar- soum (1938), Ibrahim (I 94I), Kamel (I948), Naim (1948), Mohamed (1956), and Sparrow (I966).All these took form bilharzial granuloma conjunctiva, which revealed presence Schistosoma haematobium ova.Adult worms for time Badir 946) branch superior ophthalmic...
Summary A French single‐centre retrospective study between 2010 and 2014 was undertaken to assess candiduria's incidence in kidney transplant recipients ( KTR ), the use impact of antifungal treatment on outcome. Candiduria defined as a urine culture with ≥10 3 cfu/ mL Candida species. clearance, severe complications death rates were estimated by Kaplan‐Meier methods effect Cox models. 52/1223 (4.3%) had ≥1 episode candiduria, 42 (81%) females, 18 (35%) diabetes, an 2.3/100 person‐year...
The discovery of frank bleeding from the conjunctiva, apart injury, is a relatively rare condition, but it not infrequent to find sanguinous discharge in cases severe inflammation conjunctiva.The various causes conjunctiva are vicarious menstruation, haemophilia, anaemia, jaundice, vascular tumours, lacrimal gland, regurgitation blood nose through passages, and hysteria.Spontaneous occurs weeping "bloody tears" (lacrimae cruentae, dacryohaemuhysis: Duke-Elder, I965); this mainly historical...
Most recent trials in human leukocyte antigen (HLA)-identical living donor (LD) renal transplantation have used immunosuppressive regimens with no induction therapy, corticosteroid-free long-term treatment, and calcineurin inhibitor minimization.Seven HLA-identical LD recipients were prospectively enrolled. Immunosuppression included therapy antithymocyte globulins for 10 days monotherapy mycophenolate mofetil (2 g/day) six cases sirolimus (target trough levels: 6-10 ng/mL) the last case. A...
An experimental study has been made of the ocular lesions produced by Leishmania donovani infection.Animals were injected with subconjunctivally, into anterior chamber, and vitreous.The observed experimentally conjunctival corneo-scleral nodules, interstitial keratitis, iridocyclitis, choroiditis, retinitis together vitreous haemorrhage.Subconjunctival retrobulbar injections in hamsters visceral leishmaniasis; thus, besides usual parenteral intracardiac routes often used for infecting...
The possibility of retinal haemorrhages originating from the prolonged use sodium salicylate was considered by Walsh and Hoyt (i 969) in a patient who had taken 40 grams several times week for I0 years.He been using solution sulphathiazole long time to paint his throat it suggested that this might have caused some periarteritic lesion accounting haemorrhage.Salicylates are analgesic antipyretic drugs may be given high doses up 7 8 daily periods cases rheumatic fever, rheumatoid arthritis,...
Papillary renal-cell carcinoma (pRCC) is unusual for its occurrence in kidneys with chronic dysfunction, frequent multifocality and common association papillary adenoma, a benign renal lesion morphologically indistinguishable from pRCC. Concomitant development of adenoma pRCC five transplanted kidneys, where donor recipient characteristics are well established, provided unique opportunity molecular studies de novo carcinogenesis. We aimed to study this tumor type determine whether or not the...
Kidney graft survival in simultaneous pancreas-kidney (SPK) recipients is known to decrease after pancreas failure.Sixty-three consecutive SPK were retrospectively reviewed. function and proteinuria evaluated at three months the transplantation last follow-up. Histopathologic findings of protocol biopsies performed one yr analyzed.Twelve patients lost graft. Donors' characteristics similar with or without failure. After a median follow-up 36 months, mean eGFR functional was 69.5 mL/min/1.73...
We describe a 35-year-old woman who presented with proteinuria and microscopic haematuria. Blood tests revealed low C3 complement level, no evidence of cryoglobulin. Renal biopsy showed Type 1 membranoproliferative glomerulonephritis (MPGN) isolated deposits on immunofluorescence study. Bone marrow aspirate, done for monocytopenia, was consistent diagnosis hairy cell leukaemia (HCL). Both haematological nephrological diseases completely responded to treatment cladribine, strongly suggesting...