A5012012528- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Use and Resistance
- Plant Pathogens and Fungal Diseases
- Patient Satisfaction in Healthcare
- Respiratory and Cough-Related Research
- Healthcare Systems and Technology
- Bacterial Identification and Susceptibility Testing
- Mycobacterium research and diagnosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Bacterial biofilms and quorum sensing
- Infectious Diseases and Mycology
- Nail Diseases and Treatments
- Microscopic Colitis
- Organ and Tissue Transplantation Research
- Indoor Air Quality and Microbial Exposure
- Antibiotics Pharmacokinetics and Efficacy
- COVID-19 Impact on Reproduction
- Urinary Bladder and Prostate Research
- Peripheral Artery Disease Management
- Patient-Provider Communication in Healthcare
- Viral gastroenteritis research and epidemiology
- Inhalation and Respiratory Drug Delivery
- Drug-Induced Adverse Reactions
Royal College of Surgeons in Ireland
2012-2025
Trinity College Dublin
2016-2025
Children's Health Ireland at Crumlin
2020-2024
Beaumont Hospital
2010-2023
St. James's Hospital
2017-2023
Our Lady of Lourdes Hospital
2019-2023
University Hospital of Basel
2023
University of Aberdeen
2023
Eskişehir Osmangazi University
2023
Akdeniz University
2023
Abstract Infections caused by the fungal pathogen Aspergillus fumigatus are increasingly resistant to first-line azole antifungal drugs. However, despite its clinical importance, little is known about how susceptible patients acquire infection from drug-resistant genotypes in environment. Here, we present a population genomic analysis of 218 A. isolates across UK and Ireland (comprising 153 143 65 environmental isolates). First, phylogenomic shows strong genetic structuring into two clades...
We report a case of severe COVID-19 pneumonia complicated by fatal co-infection with multi-triazole resistant Aspergillus fumigatus and highlight the importance recognising significance sp. isolation from respiratory samples. Early diagnosis detection triazole resistance are essential for appropriate antifungal therapy to improve outcome in patients coronavirus associated invasive aspergillosis.
To date, azoles represent the only viable option for oral treatment of invasive Candida infections, while rates azole resistance among non-albicans spp. continue to increase. The objective this sub-analysis European multicenter observational cohort study III was describe demographical and clinical characteristics requiring prolonged hospitalization solely complete intravenous (iv) antifungal (AF Tx).Each participating hospital (number eligible hospitals per country determined by population...
The clinical course of Staphylococcus aureus bloodstream infection is unpredictable and bacterial virulence, host immune response patient characteristics are among the factors that contribute to infection. To investigate relationship between cytokine outcome, circulating levels were investigated in S. patients with different courses A prospective study was carried out 61 IL-6, GRO-γ, RANTES leptin assessed over Levels compared complicated (e.g. infective endocarditis) versus uncomplicated...
A wide array of PCR tests has been developed to aid the diagnosis invasive aspergillosis (IA), providing technical diversity but limiting standardisation and acceptance. Methodological recommendations for testing blood samples using exist, based on achieving optimal assay sensitivity help exclude IA. Conversely, when more (BAL, biopsy, CSF) emphasis is placed confirming disease, so analytical specificity paramount. This multicenter study examined methods detecting IA by blind a panel DNA...
Recent outbreaks of Candida auris further exemplify that invasive infections are a substantial threat to patients and healthcare systems. Even short treatment delays associated with higher mortality rates. Epidemiological shifts towards more resistant spp. require careful surveillance.Triggered by the emergence C increasing antifungal resistance rates European Confederation Medical Mycology developed an international Registry (FungiScope™ CandiReg) allow contemporary multinational...
Within the last 12 months, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spread globally to pandemic proportions [...]
Abstract Infections caused by opportunistic fungal pathogens are increasingly resistant to first-line azole antifungal drugs. However, despite its clinical importance, little is known about the extent which susceptible patients acquire infection from drug genotypes in environment. Here, we present a population genomic analysis of mould Aspergillus fumigatus across United Kingdom and Republic Ireland. First, show occurrences where isolates near identical were obtained both environmental...
Coryneform bacteria are usually considered as non-pathogenic when isolated from clinical specimens. We present a case of Brevibacterium otitidis neurosurgical infection in an immunocompetent patient, and highlight the difficulty with identification interpretation antimicrobial susceptibility results for this unusual pathogen.
Summary Influenza virus infection is now recognised as a risk factor for invasive pulmonary aspergillosis ( IPA ). Delays in diagnosis contribute to delayed commencement of antifungal therapy. In addition, the emergence resistance first‐line triazole agents puts emphasis on early detection prevent adverse outcomes. We present 2 allogeneic stem cell transplant patients who developed due triazole‐resistant Aspergillus fumigatus following influenza infection. underline challenges faced...
Chronic obstructive pulmonary disease (COPD) patients have been recognized to be at increased risk of Aspergillus spp. colonization, which may progress invasive aspergillosis (IPA). The objective this study was determine the frequency or disease, in a cohort COPD patients. A prospective observational undertaken consecutive undergoing bronchoscopy. Fungal culture as well galactomannan antigen (GM) and nucleic acid detection (PCR) were performed on bronchoalveolar lavage fluid (BAL) samples....
Invasive candidiasis (IC) is the most common invasive fungal disease in patients admitted to critical care and associated with high mortality rates. Diagnosis can be delayed by poor sensitivity of culture-based methods, leading unnecessary use empirical antifungal therapy (EAFT). The biomarker (1-3)-β-d-glucan (BDG) has been shown aid diagnosis IC incorporated into stewardship (AFS) programmes.To describe our experience using a diagnostics-driven AFS programme incorporating BDG, analyse its...
High-efficiency particulate air supplied to a positive-pressure ventilation lobby (PPVL) in isolation rooms offers the dual advantage of protective and source isolation. This study demonstrates in-use validity PPVL for patients. Of 48 samples investigated, Aspergillus fumigatus was detected from only one (2%) sample. Local remote monitoring is essential safety patients healthcare workers. Remote point-of-use engineering controls are ongoing monitoring, but this should be complemented by...
has been found to coinfect patients with severe SARS-CoV-2 virus infection, leading COVID-19-associated pulmonary aspergillosis (CAPA). The CAPA all-cause mortality rate is approximately 50% and may be complicated by azole resistance. Genomic epidemiology can help shed light on the genetics of