A5100351842- MicroRNA in disease regulation
- Heat shock proteins research
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Immunotherapy and Immune Responses
- Circular RNAs in diseases
- Plant biochemistry and biosynthesis
- RNA modifications and cancer
- Toxin Mechanisms and Immunotoxins
- Natural product bioactivities and synthesis
- Nanoparticle-Based Drug Delivery
- Autophagy in Disease and Therapy
- Immune Cell Function and Interaction
- RNA Interference and Gene Delivery
- Respiratory viral infections research
- SARS-CoV-2 detection and testing
- Advanced Drug Delivery Systems
- Gestational Diabetes Research and Management
- Silk-based biomaterials and applications
- Molecular Biology Techniques and Applications
- Endoplasmic Reticulum Stress and Disease
- Monoclonal and Polyclonal Antibodies Research
- Electrospun Nanofibers in Biomedical Applications
Wenzhou University
2024-2025
Shandong University
2021-2025
Shandong Provincial Hospital
2025
Shandong First Medical University
2025
National Health and Family Planning Commission
2021-2025
Ministry of Agriculture and Rural Affairs
2024-2025
Anhui Agricultural University
2024-2025
Zhejiang Chinese Medical University
2014-2025
Shanghai Jiao Tong University
2015-2025
Jilin Agricultural University
2024-2025
The narrow host range of Mycobacterium leprae and the fact that it is refractory to growth in culture has limited research on biologic understanding leprosy. Host genetic factors are thought influence susceptibility infection as well disease progression.We performed a two-stage genomewide association study by genotyping 706 patients 1225 controls using Human610-Quad BeadChip (Illumina). We then tested three independent replication sets for an between presence leprosy 93 single-nucleotide...
Influenza A viruses (IAVs), particularly H1N1, H5N1 and H7N9, pose a substantial threat to public health worldwide. Here, we report that MIR2911, honeysuckle (HS)-encoded atypical microRNA, directly targets IAVs with broad spectrum. MIR2911 is highly stable in HS decoction, continuous drinking or gavage feeding of decoction leads significant elevation the level mouse peripheral blood lung. Bioinformatics prediction luciferase reporter assay showed could target various IAVs, including H7N9....
Combination checkpoint blockade (CCB) targeting inhibitory CTLA4 and PD1 receptors holds promise for cancer therapy. Immune-related adverse events (IRAEs) remain a major obstacle the optimal application of CCB in cancer. Here, we analyzed B cell changes patients with melanoma following treatment either anti-CTLA4 or anti-PD1, combination. therapy led to circulating cells that were detectable after first cycle characterized by decline an increase CD21lo plasmablasts. expression was higher...
<h3>Importance</h3> Coenzyme Q10 (CoQ10), an antioxidant that supports mitochondrial function, has been shown in preclinical Parkinson disease (PD) models to reduce the loss of dopamine neurons, and was safe well tolerated early-phase human studies. A previous phase II study suggested possible clinical benefit. <h3>Objective</h3> To examine whether CoQ10 could slow progression early PD. <h3>Design, Setting, Participants</h3> III randomized, placebo-controlled, double-blind trial at 67 North...
Metabolic-associated fatty liver disease (MAFLD) is witnessing a global surge; however, it still lacks effective pharmacological interventions. Fucoxanthin, natural bioactive metabolite derived from marine brown algae, exhibits promising functions, particularly in ameliorating metabolic disorders. However, the mechanisms underlying its therapeutic efficacy addressing MAFLD remain elusive. Our present findings indicated that fucoxanthin significantly alleviated palmitic acid (PA)-induced...
Cadmium (Cd) pollution significantly hampers cleaner production of peanut (Arachis hypogaea L.). Therefore, exploring tolerance mechanisms to Cd stress and breeding low-Cd cultivars are urgently needed require intense efforts. Herein, multi-omics physiological studies reveal that multiple biological processes, including melatonin (MT) biosynthesis, involved in the plants. Exogenous MT was applied plants under stress, which decreased accumulation roots, shoots seeds for 40%-60%, promoted...
Abstract Diarrhea is a leading cause of death among young mammals, especially during weaning. Here, we investigated the effects Cathelicidin-WA (CWA) on diarrhea, intestinal morphology, inflammatory responses, epithelial barrier and microbiota in intestine mammals Piglets with clinical diarrhea were selected treated saline (control), CWA or enrofloxacin (Enro) for 4 days. Both Enro effectively attenuated diarrhea. Compared control, decreased IL-6, IL-8 IL-22 levels reduced neutrophil...
To fabricate biocompatible composite films with tunable performance, both silk fibroin (SF, β‐crystallite rich) and keratin (α‐helix materials are engineered at the mesoscale based on molecular synergy. While SF display a hierarchical structure initiated from networks, reveal networks crossly linked by disulfide bonding. It is surprising to see that β‐crystallites of induce conversion free unfolded chains β‐folding (β‐crystallites) in SF/keratin composites. Furthermore, α‐helices components...
Diabetic foot wound healing is a major clinical problem due to impaired angiogenesis and bacterial infection. Therefore, an effective regenerative dressing desiderated with the function of promoting revascularization anti-bacteria. Herein, multifunctional injectable composite hydrogel was prepared by incorporation cerium-containing bioactive glass (Ce-BG) into Gelatin methacryloyl (GelMA) hydrogel. The Ce-BG synthesized combining sol-gel method template method, which maintained spherical...
The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has substantially damaged global economy and human health. spike (S) protein of coronaviruses plays a pivotal role in viral entry binding to host cell receptors. Additionally, it acts as primary target for neutralizing antibodies those infected is central focus currently utilized or researched vaccines. During virus's adaptation host, S SARS-CoV-2 undergone significant evolution. As pandemic...
Broussoflavonol B (Bf-B), a flavonoid compound identified in the roots of Daphne giraldii Nitsche, has been extensively investigated for its potential anti-inflammatory, antioxidant, and anticancer properties. However, precise mechanism underlying regulation AURKA/PLK1 pathway-mediated cell cycle arrest by Bf-B pancreatic cancer remains poorly understood. The objective this study was to investigate inhibitory effect on ductal adenocarcinoma (PDAC) mechanism. A CCK8 assay conducted identify...
The key feature of metabolic syndrome, a cluster and cardiovascular disorders, is systemic insulin resistance, which associated with dysregulated endothelial nitric-oxide synthase (eNOS). Stress signaling induced by inflammation can inhibit signaling. However, molecular mechanisms for the cross-talk between stress resistance are only partially understood. Resistin, an adipokine/cytokine, involved in inflammatory processes that could lead to status vascular diseases. In current study, we...
We report on the discovery of benzo- and pyridino- thiazolothiopurines as potent heat shock protein 90 inhibitors. The benzothiazole moiety is exceptionally sensitive to substitutions aromatic ring with a 7'-substituent essential for activity. Some these compounds exhibit low nanomolar inhibition activity in Her-2 degradation assay (28-150 nM), good aqueous solubility, oral bioavailability profiles mice. In vivo efficacy experiments demonstrate that this class inhibit tumor growth an N87...