A5027486507- Dermatologic Treatments and Research
- Laser Applications in Dentistry and Medicine
- Muscle Physiology and Disorders
- Skin Protection and Aging
- Cardiomyopathy and Myosin Studies
- Nonmelanoma Skin Cancer Studies
- Cutaneous Melanoma Detection and Management
- melanin and skin pigmentation
- Cancer and Skin Lesions
- Cutaneous lymphoproliferative disorders research
- Tuberculosis Research and Epidemiology
- Leprosy Research and Treatment
- Nail Diseases and Treatments
- Inflammatory Myopathies and Dermatomyositis
- Neurogenetic and Muscular Disorders Research
- Mycobacterium research and diagnosis
- Metabolism and Genetic Disorders
- Acne and Rosacea Treatments and Effects
- Mitochondrial Function and Pathology
- Glycogen Storage Diseases and Myoclonus
- Ear and Head Tumors
- Caveolin-1 and cellular processes
- Genetic and rare skin diseases.
- Solid State Laser Technologies
- Pituitary Gland Disorders and Treatments
Shandong Provincial Institute of Dermatology and Venereology
2008-2025
Shandong First Medical University
2008-2025
Shandong Provincial Hospital
2012-2023
Chinese PLA General Hospital
2016-2022
Academy of Medical Sciences
2011-2022
Chinese People's Liberation Army
2018
Shandong University
2012
Shanghai Jiao Tong University
2005-2008
The narrow host range of Mycobacterium leprae and the fact that it is refractory to growth in culture has limited research on biologic understanding leprosy. Host genetic factors are thought influence susceptibility infection as well disease progression.We performed a two-stage genomewide association study by genotyping 706 patients 1225 controls using Human610-Quad BeadChip (Illumina). We then tested three independent replication sets for an between presence leprosy 93 single-nucleotide...
Abstract Background and Objective Many lasers have claimed the clinical efficacy on skin rejuvenation. In this study, mechanisms of laser induced collagen remodeling were explored systematically a Kunming (KM) mouse model in vivo by comparing different non‐ablative effects using four treatment modalities. Materials Methods The dorsal KM mice was exposed depilation before treatments. Four modalities used: 595‐nm pulsed dye (PDL) (10 ms), 1,320‐nm neodymium–yttrium–aluminum garnet (Nd:YAG)...
Introduction: Tacrolimus is widely used in treating vitiligo. Drug-induced hypertrichosis a well-known side effect of cyclosporine. It less commonly associated with tacrolimus or topical calcineurin inhibitors. Four reports attributed to systemic have been previously reported the literature. In this report, we describe case focal due long-term use for Case Presentation: We present 15-year-old boy white hair 4 months, after treatment 0.1% ointment. He denied ever using other ointment area....
Previous genome-wide association studies (GWASs) identified multiple susceptibility loci that have highlighted the important role of TLR (Toll-like receptor) and CARD (caspase recruitment domain) genes in leprosy. A large three-stage candidate gene-based study 30 47 was performed leprosy samples Chinese Han. Of 4363 SNPs investigated, eight showed suggestive (P < 0.01) our previously published GWAS datasets (Stage 1). SNPs, rs2735591 rs4889841 significant 0.001) an independent series 1504...
Background: Differentiation of some seborrheic keratosis (SK) and verruca plana (VP) lesions is a challenge. Confocal laser scanning microscopy (CLSM) has been proved to be useful in the diagnosis skin diseases; however, date, there no report on differential study two diseases with CLSM. Objectives: To obtain CLSM image characteristics SK VP, then test ability imaging. Methods: We recruited 10 patients typical under images validate features reported. Another VP were also recruited, imaged...
Myoclonic epilepsy with ragged red fibers (MERRF) syndrome is characterized by myoclonus, generalized epilepsy, cerebellar ataxia, and (RRFs) in the muscle. T-to-C transition at nucleotide position 14709 mitochondrial tRNA glutamic acid (tRNAGlu) gene has previously been associated maternally inherited diabetes deafness. However, association between MERRF T14709C mutation (m.T14709C) never reported before.Clinical information of a 17-year-old patient was collected; muscle biopsy...
Background/Purpose: The objective was to compare the efficiencies of 595 nm pulsed dye and 1320 Nd : YAG laser non‐ablative rejuvenation. Methods: KM mice were irradiated with lasers. Histological changes evaluated immediately, 1, 7, 21, 30 60 days after two treatments. Skin hydration hydroxyproline content measured quantify degree improvement skin's water‐holding capacity rate synthesis. Results: Although not statistically significant, treatment induced 9.7% greater skin than while led a...
Leprosy is caused by Mycobacterium leprae, and the global registered prevalence of leprosy at beginning 2009 stood 213,036 cases. It has long been thought that a strong genetic risk. Recently, we have identified significant associations (P < 1.00 × 10(-10)) between SNPs in genes CCDC122, C13orf31, NOD2, TNFSF15, HLA-DR RIPK2 trend towards an association = 5.10 10(-5)) with SNP LRRK2. Here, investigated expression these seven formalin-fixed, paraffin-embedded skin tissues matched normal using...
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Background: Vitiligo is an acquired, idiopathic skin disorder that can significantly affect the health-related quality of life (QoL). The vitiligo-specific QoL instrument (VitiQoL), recently developed by American group, was found to be a reliable patient-reported outcome measure in both Brazilian and Iranian patients. Methods: VitiQoL initially cross-culturally adapted Chinese through forward-backward translation. version then distributed 182 vitiligo patients together with dermatology index...
Background: Pompe disease is a rare lysosomal glycogen storage disorder linked to the acid alpha-glucosidase gene (GAA). A wide clinical and genetic variability exists between patients from different ethnic populations, genotype-phenotype correlations are still not well understood. The aim of this study was report clinicopathological characteristics five Chinese with late-onset (LOPD) who carried novel GAA mutations. Methods: Clinical pathological data diagnosed at our institution April 1986...
<title>Abstract</title> <bold>Objective: </bold>To<bold> </bold>retrospectively analyze the efficacy and safety of Almonertinib in locally advanced or brain metastatic non-small cell lung cancer（NSCLC）with EGFR-positive mutations. <bold>Patients Methods: </bold>Patients with NSCLC initially diagnosed metastases (BMs) progression BMs were recruited into this study, treated Almonertinib.The patients divided two groups, mono-therapy group combined radiotherapy(RT).The primary endpoint...
Myopathies with rimmed vacuoles are a heterogeneous group of muscle disorders progressive weakness and varied clinical manifestations but similar features in biopsies. Here, we describe novel autosomal dominant myopathy large family 11 patients three generations affected.A study including history, obstetric, pediatric, development history was recorded. Clinical examinations physical examination, electromyography (EMG), serum creatine kinase (CK), bone X-rays, brain magnetic resonance imaging...
GNE myopathy is an adult-onset muscle disorder featuring distal atrophy and weakness. Rimmed vacuoles found in the biopsies gene mutations lead to diagnosis of myopathy. We collected clinical information, performed genetic testing on three patients. These cases developed typical disease presentations with weakness at ages 26, 23, 37 years. Their pathologies revealed rimmed vacuoles. Genetic analysis led findings which included, c.1543-1544delGA (p.D515QfsX2)/c.38G>C (p.C13S) compound...
Objective: To investigate the role of reflectance confocal microscopy (RCM) in differential diagnosis hypopigmented mycosis fungoides (HMF) and vitiligo. Methods: Cases with persistent patches, suspicious early stage vitiligo, or HMF were imaged RCM. The melanin contents inflammatory conditions epidermis superficial dermis lesions compared same layers adjacent skin, then, biopsied analyzed by histology. Results: 15 cases enrolled this study, based on RCM findings, there was just slight...
Abstract Pulsed dye laser (PDL) is the first‐line treatment for port‐wine stain (PWS). However, only a small portion of lesions could be completely cleared by PDL treatment, which might related to regeneration and revascularization vascular structures after irradiation. Recently, it believed that suppression photocoagulated blood vessels can achieve better therapeutic outcome. We use rabbit ear SD rat as animal models investigate whether PDL‐induced angiogenesis suppressed topical metformin....