A5064022092- Mycobacterium research and diagnosis
- Leprosy Research and Treatment
- Autoimmune Bullous Skin Diseases
- Tuberculosis Research and Epidemiology
- Drug-Induced Adverse Reactions
- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Skin and Cellular Biology Research
- Microbial Community Ecology and Physiology
- T-cell and B-cell Immunology
- Urticaria and Related Conditions
- Cutaneous lymphoproliferative disorders research
- Autoimmune and Inflammatory Disorders
- Nuclear Materials and Properties
- Genomics and Phylogenetic Studies
- Genetic and rare skin diseases.
- Pharmacological Effects of Natural Compounds
- Micro and Nano Robotics
- Asthma and respiratory diseases
- Immune Response and Inflammation
- Bacteriophages and microbial interactions
- Syphilis Diagnosis and Treatment
- Dermatological and Skeletal Disorders
- NF-κB Signaling Pathways
- Immune responses and vaccinations
Shandong First Medical University
2016-2025
Shandong Provincial Institute of Dermatology and Venereology
2016-2025
Academy of Medical Sciences
2024
Shandong Provincial Hospital
2018-2023
Thermal Power Research Institute
2023
Hubei Provincial Water Resources and Hydropower Planning Survey and Design Institute
2022
Shandong University
2010-2018
State Key Laboratory of Microbial Technology
2014-2016
Dapsone hypersensitivity syndrome (DHS) is the most serious adverse reaction associated with dapsone administration and one of major causes death in patients leprosy, whose standard treatment includes multidrug therapy (MDT) dapsone, rifampicin, clofazimine. Although HLA-B*13:01 polymorphism has been identified as genetic determinant DHS Chinese population, no studies to date have done evaluate whether prospective screening could prevent by identifying who should not receive dapsone.To...
Bullous pemphigoid (BP) is a type 2 inflammation- and immunity-driven skin disease, yet comprehensive understanding of the immune landscape, particularly immune-stromal crosstalk in BP, remains elusive. Herein, using single-cell RNA sequencing (scRNA-seq) vitro functional analyzes, we pinpoint Th2 cells, dendritic cells (DCs), fibroblasts as crucial cell populations. The IL13-IL13RA1 ligand-receptor pair identified most significant mediator BP. Notably, DCs expressing IL13RA1 respond to...
Although genome-wide association studies have greatly advanced our understanding of the contribution common noncoding variants to leprosy susceptibility, protein-coding not been systematically investigated. We carried out a three-stage study in Han Chinese, whom were 7,048 patients and 14,398 healthy control subjects. Seven coding exome-wide significance discovered, including two rare variants: rs145562243 NCKIPSD (P = 1.71 × 10-9, odds ratio [OR] 4.35) rs149308743 CARD9 2.09 10-8, OR 4.75);...
Lepromatous leprosy (L-LEP), caused by the massive proliferation of Mycobacterium leprae primarily in macrophages, is an ideal disease model for investigating molecular mechanism intracellular bacteria evading or modulating host immune response. Here, we performed single-cell RNA sequencing both skin biopsies and peripheral blood mononuclear cells (PBMCs) L-LEP patients healthy controls. In lesions, revealed remarkable upregulation APOE expression that showed a negative correlation with...
The discovery of pathogenic variants provided biological insight into the role host genetic factors in generalized pustular psoriasis (GPP). However, not all those affected by GPP carry reported genes. To comprehensively explore molecular pathogenesis GPP, whole-exome sequencing was performed, and two loci were identified with exome-wide significance through single variant association analysis: rs148755083 IL36RN gene (Pcombined = 1.19 × 10-18, OR 8.26) HLA-C∗06:02 within major...
Xenophagy plays a crucial role in restraining the growth of intracellular bacteria macrophages. However, machinery governing autophagosome‒lysosome fusion during bacterial infection remains incompletely understood. Here, we utilize leprosy, an ideal model for exploring interactions between host defense mechanisms and infection. We highlight glycoprotein nonmetastatic melanoma protein B (GPNMB), which is highly expressed macrophages from lepromatous leprosy (L-Lep) patients interferes with...
Pathogens trigger metabolic reprogramming, leading to the formation of foamy macrophages (FMs). This process provides a favorable environment for bacterial proliferation and enables bacteria evade immune killing. To elucidate mechanisms by which pathogens escape surveillance elimination via FMs. We constructed FM model using monocyte-derived (MDMs) that were incubated with oxidized low-density lipoprotein (oxLDL). Subsequently, we employed bulk RNA-sequencing (bulk RNA-seq) comprehensively...
The biological connections between psoriasis and diabetes have been suggested by epidemiological, immunological genetic studies. To identify additional shared susceptibility loci investigate pathogenesis these two diseases, we genotyped 89 reported in 4456 cases 6027 controls of Chinese population using the MassARRAY system from Sequenom. We discovered three significant associations at rs6679677 on 1p13.2 (P=6.15×10-5 , OR=5.07), rs16861329 3q27.3 (P=2.02×10-4 OR=0.87) rs849135 7p15.1...
A population-based study of Chlamydia trachomatis (CT) infections is essential in designing a specific control program; however, no large investigation CT among the general population mainland China has been conducted since 2000. We aimed to determine prevalence, risk factors, and associated medical costs residents, 18-49 years age, Shandong, China.From May August 2016, multistage probability sampling survey involving 8074 individuals was distributed. Data were collected via face-to-face...
Background The reduced amounts of Mycobacterium leprae (M. leprae) among paucibacillary (PB) patients reflect the need to further optimize methods for leprosy diagnosis. An increasing number reports have shown that droplet digital polymerase chain reaction (ddPCR) is a promising tool diagnosis infectious disease samples with low copy number. To date, no publications investigated utility ddPCR in detection M. leprae. aim this study was develop and evaluate assay PB leprosy. Methodology two...
A Gram-negative, motile, psychrotolerant, oxidase- and catalase-positive bacterium, designated BSs20135 T , was isolated from Arctic marine sediment. Cells were straight or slightly curved rods formed circular, convex yellowish-brown colonies. Buds prosthecae could be produced. The strain grew at 4–28 °C (optimum 25 °C) with 1–5 % (w/v) NaCl 2 %) hydrolysed aesculin DNA, but did not reduce nitrate to nitrite. Phylogenetic analysis of 16S rRNA gene sequences indicated that belonged the genus...
Pseudoalteromonas species are a group of marine gammaproteobacteria frequently found in deep-sea sediments, which may play important roles sediment ecosystem. Although genome sequence analysis has revealed some specific features associated with adaptation to the extreme environment, it is still difficult study how adapt environment due lack genetic manipulation system. The aim this develop system sedimentary bacterium sp. SM9913, making possible perform gene mutation by homologous...
Abstract Epidermal growth factor receptor inhibitors (EGFRIs) are widely used to treat various types of malignancies. One the common adverse reactions is cutaneous toxicity, mostly presenting as acneiform eruptions, paronychia and xerosis. Erosive pustular dermatosis scalp (EPDS) a rare reaction that develops during treatment with EGFRIs. The pathogenesis EGFRI-induced EPDS poorly understood. Here we present three cases induced by proteins LTA4H (leukotriene A-4 hydrolase), METAP1...
Leprosy is an infectious granulomatous disease caused by Mycobacterium leprae (M. leprae) that affects the skin and can lead to deformity damaging peripheral nerves. Although leprosy no longer incurable disease, its epidemic has not been well controlled because of unclear routes transmission lack effective vaccine. Moreover, long ideal model for study genetics immunology diseases due strong genetic predisposition immune-dependent spectrum clinical manifestations. Here, we review latest...
Although bacteriobenthos play a major role in the degradation of particulate organic matter marine sediment, knowledge sediment-adapted lifestyles is still scarce. Here, particle-associated, swimming and swarming benthonic bacterium Pseudoalteromonas sp. SM9913 (SM9913) were illustrated. had clay particle-associated lifestyle, its exopolysaccharide played an important this lifestyle. also motilities, indicating that it may have sediment. The lateral flagella responsible for motility, polar...
Pathogen-induced epigenetic modifications can reshape anti-infection immune processes and control the magnitude of host responses. DNA methylation profiling has identified crucial aberrant changes associated with diseases, thus providing biological insights into roles factors in mycobacterial infection. In this study, we performed a genome-wide analysis skin biopsies from patients leprosy healthy controls. T helper 17 differentiation pathway was found to be significantly through functional...
Seven new risk coding variants have been identified through an exome‐wide association study (EWAS), which studied the contributions of protein‐coding to leprosy susceptibility. But some potential susceptibility loci were not in previous EWAS because project consideration. Seventeen unstudied validated 3169 cases and 9814 controls this study. Four disease‐associated exonic identified: rs671 ALDH2 ( P = 2.0 × 10 −20 , odds ratio [OR] 1.35), rs13259978 SLC7A2 1.74 −8 OR 1.28), rs925368 GIT2...
Herpes simplex virus type-2 (HSV-2) infection is the main cause of genital ulcer disease and increases risk HIV acquisition. Little information available regards epidemiological characteristics HSV-2 among general population in China. The aim this study was to explore seroprevalence associated factors provide for design control strategy Shandong, In cross-sectional study, a total 8074 persons, 18–49 years age, were selected using multi-stage probability sampling represent Shandong 2016....
Most marine bacteria secrete exopolysaccharide (EPS), which is important for bacterial survival in the environment. However, it still unclear whether self-secreted EPS involved motility. Here we studied role of lateral flagella-driven swarming motility benthic bacterium Pseudoalteromonas sp. SM9913 (SM9913) by a comparison wild and ΔepsT, an synthesis defective mutant. Reduction production ΔepsT did not affect growth rate or swimming motility, but significantly decreased on plate, suggesting...