A5100638803- Leprosy Research and Treatment
- Mycobacterium research and diagnosis
- Psoriasis: Treatment and Pathogenesis
- Antimicrobial Peptides and Activities
- Advanced Chemical Sensor Technologies
- Tuberculosis Research and Epidemiology
- 2D Materials and Applications
- Remote Sensing in Agriculture
- Conducting polymers and applications
- Perovskite Materials and Applications
- Food Quality and Safety Studies
- Nail Diseases and Treatments
- Invertebrate Immune Response Mechanisms
- Menstrual Health and Disorders
- Renal and Vascular Pathologies
- Chalcogenide Semiconductor Thin Films
- Sexual Differentiation and Disorders
- Cardiac Arrhythmias and Treatments
- Organic Electronics and Photovoltaics
- Synthetic Organic Chemistry Methods
- Bee Products Chemical Analysis
- Chemical and Physical Studies
- Gastroesophageal reflux and treatments
- Quantum Dots Synthesis And Properties
- Polymer-Based Agricultural Enhancements
Shaanxi Blood Center
2024
Shandong Provincial Institute of Dermatology and Venereology
2022-2024
Shandong First Medical University
2022-2024
China National Health Development Research Center
2024
Shandong Provincial Hospital
2022-2023
Shanxi Agricultural University
2023
Beihang University
2022
Central South University
2021
Second Xiangya Hospital of Central South University
2021
Cleveland Clinic Lerner College of Medicine
2019
The colonizing microbiota on the body surface play a crucial role in barrier function. Staphylococcus aureus (S. aureus) is significant contributor to skin infection, and utilization of colonization resistance commensal microorganisms counteract invasion pathogens viable approach. However, most studies have focused bacteria, with limited research fungal communities pathogenic bacteria. Extracellular vehicles (EVs) an important microbial niches interaction between distinct strains. This paper...
Background Pathogens trigger metabolic reprogramming, leading to the formation of foamy macrophages (FMs). This process provides a favorable environment for bacterial proliferation and enables bacteria evade immune killing. Objective To elucidate mechanisms by which pathogens escape surveillance elimination via FMs. Methods We constructed FM model using monocyte-derived (MDMs) that were incubated with oxidized low-density lipoprotein (oxLDL). Subsequently, we employed bulk RNA-sequencing...
Lepromatous leprosy (L-LEP), caused by the massive proliferation of Mycobacterium leprae primarily in macrophages, is an ideal disease model for investigating molecular mechanism intracellular bacteria evading or modulating host immune response. Here, we performed single-cell RNA sequencing both skin biopsies and peripheral blood mononuclear cells (PBMCs) L-LEP patients healthy controls. In lesions, revealed remarkable upregulation APOE expression that showed a negative correlation with...
In recent decades, natural products have been considered important resources for developing of new agrochemicals because their novel architectures and multibioactivities. Consequently, herein, 1-O-acetylbritannilactone (ABL), a sesquiterpene lactone from Inula britannica L., was used as lead further modification to discover fungicidal candidates. Six series ABL-based derivatives containing an oxadiazole, triazole, or imidazole moiety were designed synthesized, antifungal activities also...
Pathogen-induced epigenetic modifications can reshape anti-infection immune processes and control the magnitude of host responses. DNA methylation profiling has identified crucial aberrant changes associated with diseases, thus providing biological insights into roles factors in mycobacterial infection. In this study, we performed a genome-wide analysis skin biopsies from patients leprosy healthy controls. T helper 17 differentiation pathway was found to be significantly through functional...
Antimicrobial peptides are effector molecules of the innate immunity amphibians. Here, one antimicrobial peptide cDNA precursor, prepropalustrin-2CE3, from tadpole Chinese brown frog Rana chensinensis was cloned. The coding sequence corresponding to mature palustrin-2CE subcloned into pGEX-6p-1. soluble GST-palustrin-2CE fusion protein successfully expressed in BL21(DE3)pLysS strain at 16 °C, and proportion reached 35%-39% total cellular protein. After removal GST-fusion tag, purity obtained...
Background: Antimicrobial peptides (AMPs) are promising alternative agents for antibiotics to overcome antibiotic resistance problems. But, it is difficult produce large-scale antimicrobial research due the toxicity towards expression hosts or degradation by peptidases in host. Therefore, heterologous recombinant of has always been a challenging issue. Objective: To host and low level, new photocleavable protein fusion method provided. Methods: Through directed evolution high throughput...
Abstract We have synthesized series of superabsorbent polymers (SAPs) by solution free radical polymerization acrylic acid (AA), acrylamide (AM) with different functional monomers (FM). Three including zwitterionic monomer [3‐(methacryloylamino) propyl] dimethyl (3‐sulfopropyl) ammonium (MPDSA), cationic (3‐acrylamidopropyl) trimethylammonium chloride (APTAC) and anionic 2‐acrylamidoglycolic monohydrate (AGAM) were selected to provide charged groups on the superabsorbents. The effect...
M. leprae preferentially infects Schwann cells (SCs) in the peripheral nerves leading to nerve damage and irreversible disability. Knowledge of how interacts with host SCs is essential for understanding mechanisms revealing potential new therapeutic strategies. We performed a time-course single-cell sequencing analysis infected at different time points, further analyzed heterogeneity SCs, subpopulations associated infection, developmental trajectory validated by Western blot or flow...
The prenatal diagnosis yield of congenital heart disease by echocardiography is only about 40 % due to the impact multiple factors on observation fetal heart. Improvement diagnostic efficiency essential reduce neonatal mortality and improve perinatal survival, which in line with national policy China quality birth population age-related mortality. current research was performed evaluate four-dimensional plus two-dimensional speckle tracking disease. Pregnant women malformations who underwent...