A5022782294- Plant-derived Lignans Synthesis and Bioactivity
- Phytochemical compounds biological activities
- Insect Pest Control Strategies
- Allelopathy and phytotoxic interactions
- Magnolia and Illicium research
- Traditional and Medicinal Uses of Annonaceae
- Oxidative Organic Chemistry Reactions
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Essential Oils and Antimicrobial Activity
- Sesquiterpenes and Asteraceae Studies
- Fungal Plant Pathogen Control
- Sulfur-Based Synthesis Techniques
- Luminescence and Fluorescent Materials
- Synthesis and Biological Evaluation
- S100 Proteins and Annexins
- Autophagy in Disease and Therapy
- Synthesis of Indole Derivatives
- Molecular Sensors and Ion Detection
- Plant tissue culture and regeneration
- Synthetic Organic Chemistry Methods
- Influenza Virus Research Studies
- Piperaceae Chemical and Biological Studies
- Insect-Plant Interactions and Control
- ATP Synthase and ATPases Research
Shanxi Agricultural University
2017-2025
Shanxi Medical University
2023-2024
Zhejiang Normal University
2023
Northwest A&F University
2012-2020
Haikou City People's Hospital
2019
College of Medical Sciences
2015
State Council of the People's Republic of China
2015
Henan Psychiatric Hospital
2008-2009
In continuation of our program aimed at the discovery and development natural-product-based pesticidal agents, 54 novel N-arylsulfonyl-3-acylindole arylcarbonyl hydrazone derivatives were prepared, their structures well characterized by ¹H NMR, ¹³C HRMS, ESI-MS, mp. Their nematicidal activity was evaluated against that pine wood nematode, Bursaphelenchus xylophilus in vivo. Among all derivatives, especially V-12 V-39 displayed best promising with LC₅₀ values 1.0969 1.2632 mg/L, respectively....
Currently, the development of novel pesticides remains a crucial initiative to address challenges agricultural pest management. In pursuit agrochemical candidates derived from plant natural products (NPs), 76 isoxazoline-hybridized honokiol/magnolol analogues were assembled via [3 + 2] dipolar cycloaddition reaction, and their pesticidal potency cytotoxicity evaluated. Bioassays revealed that 13 compounds (5d, 6k, 7b-d, 7f, 7g, 8d-f, 13f, 15d, 16h) exhibited superior larvicidal activity...
Abstract BACKGROUND Persistent and excessive application of conventional synthetic pesticides has triggered a series environmental agricultural product safety risks in recent decades. Natural products are considered to provide considerable sources for the innovation novel ecofriendly agrochemicals with high efficacy. RESULTS In this work, structural splicing strategy was used prepare 37 honokiol‐derived thioether analogs bearing different heterocyclic scaffolds their pesticidal activities...
In continuation of our program aimed at the discovery and development natural-product-based insecticidal agents, 33 isoxazoline oxime derivatives podophyllotoxin modified in C D rings were synthesized their structures characterized by Proton nuclear magnetic resonance (1H NMR), high-resolution mass spectrometry (HRMS), electrospray ionization–mass (ESI–MS), optical rotation, melting point (mp), infrared (IR) spectroscopy. The stereochemical configurations compounds 5e, 5f, 9f unambiguously...
In continuation of our program aimed at the discovery and development natural-product-based insecticidal agents, we have prepared three series novel 4α-(acyloxy)-2'(2',6')-(di)halogenopodophyllotoxin derivatives modified in C E rings podophyllotoxin, which is a naturally occurring aryltetralin lignan isolated from roots rhizomes Podophyllum hexandrum . Their structures were well characterized by (1)H NMR, HRMS, ESI-MS, optical rotation, mp. The stereochemical configurations compounds 5s, 6b,...
To discover novel natural-product-based pesticidal agents, we prepared a series of oxime sulfonate derivatives 2'(2',6')-(Di)chloropicropodophyllotoxins by structural modification podophyllotoxin. Their structures were well-characterized proton nuclear magnetic resonance ((1)H NMR), high-resolution mass spectrometry (HRMS), optical rotation, and melting point. Moreover, the key steric structure compound 5f was unambiguously determined single-crystal X-ray diffraction. Additionally, their...
In recent decades, natural products have been considered important resources for developing of new agrochemicals because their novel architectures and multibioactivities. Consequently, herein, 1-O-acetylbritannilactone (ABL), a sesquiterpene lactone from Inula britannica L., was used as lead further modification to discover fungicidal candidates. Six series ABL-based derivatives containing an oxadiazole, triazole, or imidazole moiety were designed synthesized, antifungal activities also...
In continuation of a program aimed at the discovery and development natural products-based insecticidal agents, two series novel fraxinellone-based esters were synthesized by modification C-4 or C-10 position fraxinellone evaluated for their activity against pre-third-instar larvae Mythimna separata in vivo. An efficient method stereoselective synthesis 4α-hydroxyfraxinellone from fraxinellonone was developed, steric configuration 6h unambiguously confirmed X-ray crystallography. Among 37...
As part of our ongoing efforts to discover novel agricultural fungicidal candidates from natural sesquiterpene lactones, in the present work, sixty-three xanthatin-based derivatives containing a arylpyrazole, arylimine, thio-acylamino, oxime, oxime ether, or ester moiety were synthesized. Their structures well characterized by 1H and 13C nuclear magnetic resonance high-resolution mass spectrometry, while absolute configurations compounds 5' 6a further determined single-crystal X-ray...
As a continuation of our efforts to develop new agrochemicals with typical architecture and efficient bioactivity from plant natural products, neolignan honokiol was used as lead compound prepare novel analogs bearing the core 2-aminobenzoxazole scaffold. Their insecticidal potency against two representative agricultural pests,
In continuation of our program aimed at the discovery and development natural-product-based insecticidal agents, a series new deoxypodophyllotoxin-based phenazine analogues modified in their E-ring were prepared, structures well characterized by ¹H NMR, HRMS, ESI-MS, IR, optical rotation, mp. The absolute steric configuration one key isomer was unambiguously confirmed X-ray crystallography. Their activity examined against pre-third-instar larvae oriental armyworm, Mythimna separata (Walker)...
Some compounds exhibited more promising insecticidal activity than toosendanin (a positive control). QSAR model suggested that five descriptors (RDF100v, RDF105u, Dm, Mor15m and R1u) were likely to affect the of these compounds.
As part of ongoing efforts to discover new natural-product-based insecticidal agents, in the present study, an efficient method for stereoselective α-chlorination at C-2 position 2'(2',6')-(di)halogenopodophyllotoxin derivatives was first developed. Subsequently, a series novel esters 2α-chloro-2'(2',6')-(di)halogenopicropodophyllotoxin with modified C, D, and E rings podophyllotoxin were smoothly obtained. Finally, all title compounds tested against pre-third-instar larvae oriental armyworm...
Vascular inflammation induced by angiotensin II-1 receptor autoantibody (AT1-AA) is involved in the occurrence and development of various cardiovascular diseases. miR-339-3p closely related to degree vasodilation aortic aneurysm also acute pancreatitis. However, it still unclear whether influences AT1-AA-induced vascular inflammation. In this study, role mechanism are studied. RT-PCR detection shows that levels thoracic aorta serum exosomes AT1-AA-positive rats significantly increased. The...