A5031707431- Nanoplatforms for cancer theranostics
- Ultrasound and Hyperthermia Applications
- Autophagy in Disease and Therapy
- Photodynamic Therapy Research Studies
- Ultrasound and Cavitation Phenomena
- Essential Oils and Antimicrobial Activity
- Traditional and Medicinal Uses of Annonaceae
- Bioactive Natural Diterpenoids Research
- Cancer Research and Treatments
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Gut microbiota and health
- MicroRNA in disease regulation
- Photoacoustic and Ultrasonic Imaging
- Piperaceae Chemical and Biological Studies
- Extracellular vesicles in disease
- RNA Research and Splicing
- Circular RNAs in diseases
- Phytochemistry and Bioactive Compounds
- Phytochemical compounds biological activities
- Hydrogen's biological and therapeutic effects
- Ferroptosis and cancer prognosis
- Immunotherapy and Immune Responses
- Heme Oxygenase-1 and Carbon Monoxide
- Phytochemistry and Biological Activities
Puer University
2023-2025
Nankai University
2024-2025
Second Affiliated Hospital of Jilin University
2024-2025
Dalian Medical University
2021-2024
First Affiliated Hospital of Dalian Medical University
2021-2024
Pudong Medical Center
2021-2024
Fudan University
2021-2024
Shaanxi Blood Center
2016-2024
Shanghai University of Traditional Chinese Medicine
2023
Zhuhai People's Hospital
2023
The facultative intracellular bacterium Listeria monocytogenes (Lmo) has great potential for development as a cancer vaccine platform given its properties. However, the clinical application of Lmo been severely restricted due to rapid clearance, compromised immune response in tumors, and inevitable side effects such severe systemic inflammation after intravenous administration. Herein, an immunotherapy system was developed on basis natural red blood cell (RBC) membranes encapsulated with...
Rationale: Cardiac fibrosis is associated with various cardiovascular diseases and can eventually lead to heart failure.Dysregulation of long non-coding RNAs (lncRNAs) has recently been recognized as one the key mechanisms involved in cardiac diseases.However, potential roles underlying lncRNAs have not explicitly delineated.Methods Results: Using a combination vitro vivo studies, we identified lncRNA NONMMUT022555, which designated pro-fibrotic (PFL), revealed that PFL up-regulated hearts...
More evidence is emerging of the roles long non-coding RNAs (lncRNAs) play as regulatory factors in a variety biological processes, but mechanisms underlying function lncRNAs acute myocardial infarction (AMI) have not been explicitly delineated. The present study identified lncRNA 2810403D21Rik/AK007586/Mirf (myocardial infarction-regulatory factor), that inhibited macroautophagy/autophagy by modulating Mir26a (microRNA 26a). Inhibition led to cardiac injury both vitro and vivo, whereas...
Abstract Background Colorectal cancer (CRC) incidence is increasing in recent years due to intestinal flora imbalance, making oral probiotics a hotspot for research. However, numerous studies related regulation ignore its internal mechanisms without in-depth Results Here, we developed probiotic microgel delivery system ( L.r @(SA-CS) 2 ) through the layer-by-layer encapsulation technology of alginate (SA) and chitosan (CS) improve gut microbiota dysbiosis enhance anti-tumor therapeutic...
Acute kidney injury (AKI) is a common and severe clinical condition. However, the underlying mechanisms of AKI have not been fully elucidated, effective treatment options remain limited. Studies shown that immune cells play critical role in AKI, with regulatory T (Tregs) being one most important immunosuppressive lymphocytes. Tregs proliferation can attenuate whereas depletion exacerbates injury. Given endothelial (ECs) are initial interact when they invade tissue parenchyma, ECs closely...
// Longtao Huangfu 1, * , Haihai Liang Guojie Wang Xiaomin Su 1 Linqiang Li 2 Zhimin Du 3 Meiyu Hu Yuechao Dong Xue Bai Tianyi Liu Baofeng Yang Hongli Shan Department of Pharmacology State-Province Key Laboratories Biomedicine-Pharmaceutics China, Laboratory Cardiovascular Research, Ministry Education, Harbin Medical University, Harbin, Heilongjiang 150081, P. R. China General Surgery, The First Affiliated Hospital Institute Clinical Pharmacy, 2nd Hospital, These authors contributed equally...
Due to low success rates and long cycles of traditional drug development, the clinical tendency is apply omics techniques reveal patient-level disease characteristics individualized responses treatment. However, heterogeneous form data uneven distribution targets make discovery precision medicine a non-trivial task. This study takes pyroptosis therapy for triple-negative breast cancer (TNBC) as paradigm uses mining large TNBC cohort databases establish biofactor-regulated neural network...
The colonizing microbiota on the body surface play a crucial role in barrier function. Staphylococcus aureus (S. aureus) is significant contributor to skin infection, and utilization of colonization resistance commensal microorganisms counteract invasion pathogens viable approach. However, most studies have focused bacteria, with limited research fungal communities pathogenic bacteria. Extracellular vehicles (EVs) an important microbial niches interaction between distinct strains. This paper...
Ferroptosis has received ever-increasing attention due to its unparalleled mechanism in eliminating resistant tumor cells. Nevertheless, the accumulation of toxic lipid peroxides (LPOs) at site is limited by level oxidation. Herein, leveraging versatile sodium alginate (ALG) hydrogel, a localized ferroptosis trigger consisting gambogic acid (GA), 2,2'-azobis [2-(2-imidazolin-2-yl) propane] dihydrochloride (AIPH), and Ink (a photothermal agent), was constructed via simple intratumor...
Pressure-induced nitrogen-rich compounds hold significant application prospects in high-energy-density materials. Utilizing first-principles calculations and swarm-intelligence structure search methods, we have identified ten new types of Gd-N with different configurations, such as one-dimensional N-chains composed N6 rings or N8 rings, two-dimensional N-layers constructed N14 N18 + rings. Moreover, the predicted exhibit magnetic properties, a phase diagram is pressure range 0 to 200 GPa....
BACKGROUND Certain subgroups are at an increased risk of false fecal immunochemical test (FIT) results; however, related studies limited, and the available evidence is conflicting. AIM To evaluate factors associated with false-positive false-negative FIT results. METHODS This retrospective study was based on database Tianjin Colorectal Cancer Screening Program from 2012 to 2020. A total 4129947 residents aged 40-74 years completed least one FIT. Of these, 24890 asymptomatic participants who...
The present study aims to investigate apoptosis of U937 cells induced by hematoporphyrin monomethyl ether (HMME)-mediated sonodynamic therapy (SDT).HMME concentration was kept constant at 10 μg/mL. Tumor suspended in serum-free RPM1640 were exposed ultrasound 1.1 MHz for up 60 seconds with an intensity 1 W/cm(2) the presence and absence HMME. viability determined 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltertrazolium bromide tetrazolium (MTT) test. Apoptosis analyzed using a flow cytometer...
Significance Stroke is a leading cause of mortality and permanent disability in adults worldwide. Although most pharmacological neuroprotectants have beneficial effects experimental studies, they fail clinical trials. Here, we report that MR-409, synthetic analog growth hormone–releasing hormone, can reduce improve neurological functional recovery mice operated on for tMCAO. Mechanistically, MR-409 stimulates endogenous neurogenesis improves tMCAO-induced loss neuroplasticity by activation...
The aim of this paper was to investigate whether sinoporphyrin sodium (DVDMS) could be a novel sonosensitizer in sonodynamic therapy. We used two kinds leukemia cells (K562, U937) as main tumor cell models and (peripheral blood mononuclear cells, spleen lymphocytes) separated from healthy ICR mice normal models. multivolume spectrophotometer system fluorescence were determine the spectral characteristics DVDMS. uptake DVDMS by measured flow cytometry. MTT assay examine cytotoxicity...
Pulmonary fibrosis is a progressive disease characterized by epithelial cell damage, fibroblast proliferation, excessive extracellular matrix (ECM) deposition, and lung tissue scarring. Melatonin, hormone produced the pineal gland, plays an important role in multiple physiological pathological responses organisms. However, function of melatonin development bleomycin-induced pulmonary injury poorly understood. In present study, we found that significantly decreased mortality restored alveolar...
Acute myocardial infarction (AMI) is the leading cause of death worldwide. Identifying pathways that block cardiac cell a therapeutic strategy for ischemic heart disease. We found long noncoding RNA (lncRNA) infarction-regulatory factor (MIRF) promoted injury by regulating autophagy through targeting miR-26a. However, role MIRF-miR-26a in apoptosis during AMI has not been delineated. In this study, we downregulation miR-26a both (MI) mice and H2O2-treated cardiomyocytes. silencing resulted...