A5102826017- Bone Metabolism and Diseases
- Mesenchymal stem cell research
- MicroRNA in disease regulation
- Bone Tissue Engineering Materials
- Autophagy in Disease and Therapy
- Medicinal plant effects and applications
- Bipolar Disorder and Treatment
- Genetics and Neurodevelopmental Disorders
- Mitochondrial Function and Pathology
- Plant-based Medicinal Research
- Bone and Joint Diseases
- Medical and Biological Sciences
- Protein Tyrosine Phosphatases
- Natural product bioactivities and synthesis
- Axon Guidance and Neuronal Signaling
- Neuroscience and Neuropharmacology Research
- Cancer-related molecular mechanisms research
- Computational Drug Discovery Methods
- Rheumatoid Arthritis Research and Therapies
- Magnesium Alloys: Properties and Applications
- Orthopaedic implants and arthroplasty
- Amino Acid Enzymes and Metabolism
- Graphene and Nanomaterials Applications
Air Force General Hospital PLA
2025
Chengdu University
2025
Harbin Medical University
2020
Dalian Medical University
2017-2019
Chongqing Medical University
2017
Roslin Institute
2013
University of Edinburgh
2013
Chinese Academy of Sciences
1998
Center for Excellence in Molecular Cell Science
1998
Vascular calcification shares many similarities with skeletal mineralisation and involves the phenotypic trans‐differentiation of vascular smooth muscle cells (VSMCs) to osteoblastic within a calcified environment. Various microRNAs (miRs) are known regulate cell differentiation; however, their role in mediating VSMC is not fully understood. miR‐microarray analysis revealed significant down‐regulation range miRs following nine days culture, including miR‐199b, miR‐29a, miR‐221, miR‐222...
Preserved duck egg yolk (PEY) can be divided into a solidified outer layer (S-PEY) and liquid inner core (L-PEY) during the middle-later stages of alkaline pickling. The differences among PEY, S-PEY, L-PEY were systematically investigated using property characterization, nutrient determination, lipidomics analysis. results demonstrated that exhibited more vivid red-yellow color, with higher total protein, lipid, phosphorus contents compared to S-PEY. Conversely, pH, moisture, sodium in S-PEY...
Targeting fibroblast-like synoviocyte (FLS) migration and invasion-mediated bone erosion is a promising clinical strategy for the treatment of rheumatoid arthritis (RA). Drug sensitivity testing fundamental to this scheme. We designed microfluidic chip-based, cell co-cultured platform mimic RA FLS-mediated perform drug-sensitive assay. Human synovium SW982 cells were cultured in central channel migrated flow through matrigel-coated side channels towards culture chamber where RANKL-stimulated...
Our previous study showed that wedelolactone, a compound isolated from Ecliptae herba, has the potential to enhance osteoblastogenesis. However, molecular mechanisms by which wedelolactone promoted osteoblastogenesis bone marrow mesenchymal stem cells (BMSCs) remain largely unknown. In this study, treatment with (2 μg/mL) for 3, 6, and 9 days resulted in an increase phosphorylation of extracellular signal-regulated kinases (ERKs), c-Jun N-terminal protein kinase (JNK), p38. Phosphorylation...
Acute myocardial infarction (AMI) is the leading cause of death worldwide. Identifying pathways that block cardiac cell a therapeutic strategy for ischemic heart disease. We found long noncoding RNA (lncRNA) infarction-regulatory factor (MIRF) promoted injury by regulating autophagy through targeting miR-26a. However, role MIRF-miR-26a in apoptosis during AMI has not been delineated. In this study, we downregulation miR-26a both (MI) mice and H2O2-treated cardiomyocytes. silencing resulted...
Abstract Regenerative medicine has a high demand for the development of scaffold materials combined with other osteogenic inducers to generate bioactive composite bone replacement therapies. Previously, we reported that wedelolactone promoted osteoblastogenesis marrow mesenchymal stem cells (BMSCs). In this study, effect hydroxyapatites (HAps), prepared, and HAps on differentiation was first evaluated. Three kinds constructed by rod‐like shape particle size 25 nm (HAp‐1), 37 (HAp‐2), 33...