A5004602514- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Ubiquitin and proteasome pathways
- RNA Interference and Gene Delivery
- Cancer-related gene regulation
- Zebrafish Biomedical Research Applications
- Hippo pathway signaling and YAP/TAZ
- Immune cells in cancer
- Aluminum Alloys Composites Properties
- Glioma Diagnosis and Treatment
- Biopolymer Synthesis and Applications
- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- RNA Research and Splicing
- Advanced ceramic materials synthesis
- Peptidase Inhibition and Analysis
- Cancer Cells and Metastasis
- Advanced Drug Delivery Systems
- Protein Degradation and Inhibitors
- FOXO transcription factor regulation
Northeastern University
2015-2025
Ningxia Medical University
2025
Ningxia Medical University General Hospital
2025
Tianjin Medical University
2012-2024
Central South University
2016-2024
Liaocheng University
2024
National Institutes for Food and Drug Control
2013-2024
Xiangya Hospital Central South University
2016-2024
Southwest University
2014-2024
Jining Medical University
2020-2024
Long noncoding RNAs (lncRNA) have been associated with various types of cancer; however, the precise role many lncRNAs in tumorigenesis remains elusive. Here we demonstrate that cytosolic lncRNA P53RRA is downregulated cancers and functions as a tumor suppressor by inhibiting cancer progression. Chromatin remodeling proteins LSH Cfp1 silenced or increased expression, respectively. bound Ras GTPase-activating protein-binding protein 1 (G3BP1) using nucleotides 871 RRM interaction domain G3BP1...
Abstract Background Ovarian cancer (OvCa) is one of the most common malignant diseases female reproductive system in world. The majority OvCa diagnosed with metastasis abdominal cavity. Epithelial-to-mesenchymal transition (EMT) plays a key role tumor cell metastasis. However, it still unclear whether long non-coding RNA (lncRNA) implicated EMT and influences invasion OvCa. Results In this study, using bioinformatcis analysis, we constructed lncRNA-mediated competing endogenous (ceRNA)...
Ferroptosis is a newly discovered form of non-apoptotic cell death in multiple human diseases.However, the epigenetic mechanisms underlying ferroptosis remain poorly defined.First, we demonstrated that lymphoid-specific helicase (LSH), which DNA methylation modifier, interacted with WDR76 to inhibit by activating lipid metabolism-associated genes, including GLUT1, and related genes SCD1 FADS2, turn, involved Warburg effect.WDR76 targeted these expression dependent manner LSH chromatin...
Ca2+ homeostasis-a critical determinant of cardiac contractile function-is critically regulated by SERCA2a (sarcoplasmic reticulum Ca2+-ATPase 2a). Our previous study has identified ZFAS1 as a new lncRNA biomarker acute myocardial infarction (MI). To evaluate the effects on and associated homeostasis function in setting MI. expression was robustly increased cytoplasm sarcoplasmic mouse model MI cellular hypoxia. Knockdown endogenous virus-mediated silencing shRNA partially abrogated...
Genomics offered the promise of transforming antibiotic discovery by revealing many new essential genes as good targets, but results fell short promise. While numerous factors contributed to disappointing yield, one factor was that for a bacterial species were often defined based on single or limited number strains grown under in vitro laboratory conditions. In fact, essentiality gene can depend both genetic background and growth condition. We thus developed strategy more rigorously defining...
Graphene oxide (GO) has attracted enormous interests due to its extraordinary properties. Recent studies have confirmed the cytotoxicity of GO, we further investigate mutagenic potential in this study. The results showed that GO interfered with DNA replication and induced mutagenesis at molecular level. treatments concentrations 10 100 μg/mL altered gene expression patterns cellular level 101 differentially expressed genes mediated DNA-damage control, cell apoptosis, cycle metabolism....
This study evaluates the reversal effects of graphene oxide (GO) used as a carrier for adriamycin (ADR) in cancer drug resistance, and provides preliminary investigation into mechanism. ADR was loaded onto GO surface (ADR–GO) by physical mixing loading content found to be high, up 93.6%. In vitro releases from ADR–GO were studied using dialysis method, they exhibited significant pH-sensitive property. Cell experiments showed that significantly enhanced accumulation MCF-7/ADR cells (an...
More evidence is emerging of the roles long non-coding RNAs (lncRNAs) play as regulatory factors in a variety biological processes, but mechanisms underlying function lncRNAs acute myocardial infarction (AMI) have not been explicitly delineated. The present study identified lncRNA 2810403D21Rik/AK007586/Mirf (myocardial infarction-regulatory factor), that inhibited macroautophagy/autophagy by modulating Mir26a (microRNA 26a). Inhibition led to cardiac injury both vitro and vivo, whereas...
Abstract Background E2F transcription factors are considered to be important drivers of tumour growth. E2F7 is an atypical factor, and its role in glioblastoma remains undefined. Methods expression was examined patients by IHC qRT-PCR. The overall survival probability determined statistical analyses. MTT assay, colony formation, cell-cycle cell metastasis the vivo model were employed determine functional glioblastoma. Chromatin immunoprecipitation, luciferase assay western blot used explore...
Ferroptosis is an iron-dependent oxidative, nonapoptotic form of regulated cell death caused by the destruction redox homeostasis. Recent studies have uncovered complex cellular networks that regulate ferroptosis. GINS4 a promoter eukaryotic G 1 /S - cycle as regulator initiation and elongation DNA replication, but little known about its impact on Here, we found was involved in regulation ferroptosis lung adenocarcinoma (LUAD). CRISPR/Cas9-mediated KO facilitated Interestingly, depletion...
Yes-associated protein 1 (YAP1) contributes to the development of multiple tumors, but mechanism underlying YAP1 deregulation in non-small cell lung cancer (NSCLC) remains unclear. By performing immunohistochemistry (IHC) assays, we found that was significantly upregulated NSCLC compared with adjacent tissues; therefore, sought elucidate whether upregulation progression. MTT and transwell assays showed overexpression promoted proliferation, migration, invasion lines A549 H460; also...
// Rui Yang 1 , Yanan Wu Mei Wang Zhongfeng Sun Jiahua Zou Yundong Zhang 2 Hongjuan Cui State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400715, P.R. China Department Neurosurgery, Research Institute Surgery, Daping Hospital, Third Military Medical 400042, Correspondence to: Cui, e-mail: hongjuan.cui@gmail.com hcui@swu.edu.cn Zhang, zhangxh68@sina.com Keywords: HDAC9, TAZ, cell cycle, EGFR, Glioblastoma Received: December 8, 2014 Accepted: January 26, 2015...
Abstract The POU Class Homeobox 2 (POU2F2) is a member of transcription factors family, which involves in cell immune response by regulating B proliferation and differentiation genes. Recent studies have shown that POU2F2 acts as tumor-promoting roles some cancers, but the underlying mechanism remains little known. Here, we identified highly expressed significantly correlated with poor prognosis glioblastoma (GBM) patients. promoted regulated glycolytic reprogramming. Mechanistically,...
Ferroptosis, a form of regulated cell death induced by excessive accumulation reactive oxygen species and lipid peroxidation, has recently attracted extensive attention due to its ability effectively suppress tumors overcome drug resistance. Unlike previously reported metal nanomaterials that induce ferroptosis via the Fenton reaction, arsenene nanosheets can deplete intracellular glutathione then inhibiting peroxidase 4. In this study, we designed target-modified loaded with cisplatin...
The signaling pathway-based stratification in chromatin modification could predict clinical outcome more reliably than morphology-alone-based classification schemes gliomas. Here we reported a role of the chromatin-remodeling factor lymphoid-specific helicase (LSH) Among astrocytomas grade I to III and glioblastoma IV, LSH were almost completely expressed all cases, strongly correlated with progression poor prognosis patients glioblastoma. Ectopic expression promoted tumor formation....
Cellular senescence is a stable cell-cycle arrest induced by telomere shortening and various types of cellular stress including oxidative stress, oncogene activation, DNA damage etc. Heme oxygenase-1 (HO-1) an inducible stress-response protein that plays antioxidant anti-apoptotic effects. However, the role underlying mechanisms HO-1 in heart are largely unknown.Echocardiography was employed to detect effect on function adult mice with myocardial infarction (MI) aged mice. The markers, p53,...
Abstract Background A deeper mechanistic understanding of epithelial-to-mesenchymal transition (EMT) regulation is needed to improve current anti-metastasis strategies in ovarian cancer (OvCa). This study was designed investigate the role lncRNAs EMT during process invasion-metastasis serous OvCa for OvCa. Methods We systematically analyzes high-throughput gene expression profiles both and protein-coding genes samples with integrated epithelial (iE) subtype mesenchymal (iM) labels. Mouse...
Elucidating mechanisms in oncogenes and epigenetic modifiers are needed to gain insights into the etiology treatment of cancer, regulation oncogene by chromatin at post-transcriptional level is critical remains unclear. We have investigated role GINS4 NSCLC.The expression modifier lymphoid-specific helicase (LSH) was assessed tumor normal tissue from 79 patients with NSCLC clinical characteristics. HBE, A549, H358, H522, PC9, 95C 95D were cultured after overexpression or silencing GIAT4RA....
Alterations in transcriptional regulators of glycolytic metabolism have been implicated brain tumor growth, but the underlying molecular mechanisms remain poorly understood.Knockdown and overexpression cells were used to explore functional roles HOXA3 cell proliferation, formation, aerobic glycolysis. Chromatin immunoprecipitation, luciferase assays, western blotting performed verify regulation HK2 PKM2 by HOXA3. PLA, Immunoprecipitation, GST-pull-down assays examine interaction KDM6A.We...
Breast cancer (BC) is the most commonly diagnosed in women, providing a leading cause of death from malignancy. Pentraxin 3 (PTX3) and protein kinase C ζ (PKCζ) are both known to exert important roles progression multiple types tumors, including BC. The present study aimed explore their interaction role promoting proliferation metastasis expression level PTX3 was found be elevated patients with BC cells; furthermore, it associated lymph node Knockdown decreased rate cell effects series...