A5101907181- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Photosynthetic Processes and Mechanisms
- Advanced biosensing and bioanalysis techniques
- Ferroptosis and cancer prognosis
- Plant Reproductive Biology
- Reproductive Biology and Fertility
- Cancer Immunotherapy and Biomarkers
- Ovarian function and disorders
- Genetic Mapping and Diversity in Plants and Animals
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Advanced Nanomaterials in Catalysis
- Cardiac Fibrosis and Remodeling
- Pediatric health and respiratory diseases
- Balance, Gait, and Falls Prevention
- Hippo pathway signaling and YAP/TAZ
- Healthcare and Venom Research
- Cancer Mechanisms and Therapy
- Advanced Photocatalysis Techniques
- Plasma Applications and Diagnostics
- Lymphoma Diagnosis and Treatment
- Seaweed-derived Bioactive Compounds
- Hip and Femur Fractures
Sichuan Agricultural University
2020-2025
Xiamen University
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
Peking Union Medical College Hospital
2022-2025
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2021-2024
Guangdong Province Women and Children Hospital
2021-2024
Zunyi Medical University
2023-2024
Hebei University
2024
Huazhong Agricultural University
2021
Northwest A&F University
2021
A novel photoelectrochemical (PEC) enzyme immunoassay was designed for the ultrasensitive detection of alpha-fetoprotein (AFP) based on near-infrared (NIR) light-excited core–core–shell UCNP@Au@CdS upconversion nanospheres. Plasmonic gold (Au) between sandwiched layers not only utilized as an energy harvester collection incident light but also acted conveyor to transfer from NaYF4:Yb3+,Er3+ (UCNP) semiconductor CdS, thus exciting efficient separation electron–hole pairs by generated H2O2...
This work developed a near-infrared (near-IR) light-activated non-enzymatic signal-off photoelectrochemical (PEC) immunoassay for the ultrasensitive detection of α-fetoprotein (AFP) on basis branched polyethylenimine (BPEI)-modified upconversion nanoparticle (UCNP)@CdTe quantum dot (QD) nanostructures by coupling with synergistic effect dual-purpose copper ions. Emission light originated from NaYF4:Yb,Er UCNP was directly utilized through electrostatic bonding CdTe QDs to excite separation...
Yes-associated protein 1 (YAP1) contributes to the development of multiple tumors, but mechanism underlying YAP1 deregulation in non-small cell lung cancer (NSCLC) remains unclear. By performing immunohistochemistry (IHC) assays, we found that was significantly upregulated NSCLC compared with adjacent tissues; therefore, sought elucidate whether upregulation progression. MTT and transwell assays showed overexpression promoted proliferation, migration, invasion lines A549 H460; also...
In this study, we designed a novel dual-readout biosensing protocol for quantitative or qualitative screening of antibiotic residues (Kanamycin; Kana used in case) using spectrofluorometer and <italic>via</italic> naked-eye detection.
To compare the biomechanical properties of proximal femur bionic nail (PFBN), femoral antirotation (PFNA) and InterTan in treatment elderly intertrochanteric fractures AO/OTA 31-A1.3 by finite element analysis.We used Mimics, Unigraphics other software to establish normal fracture models, reconstructed PFBN, PFNA intramedullary assembled them on model. The ANSYS was von Mises stress distribution, deformation internal fixation distribution each group under a load 2100 N.It could be seen that...
Cellular senescence is a stable cell-cycle arrest induced by telomere shortening and various types of cellular stress including oxidative stress, oncogene activation, DNA damage etc. Heme oxygenase-1 (HO-1) an inducible stress-response protein that plays antioxidant anti-apoptotic effects. However, the role underlying mechanisms HO-1 in heart are largely unknown.Echocardiography was employed to detect effect on function adult mice with myocardial infarction (MI) aged mice. The markers, p53,...
Accumulating evidence suggested that radiotherapy can activate anti-tumor immune responses by triggering immunogenic cell death (ICD) of tumor cells. Calreticulin is regarded as one the most important markers ICD. The surface translocation calreticulin (ecto-CRT) serves an "eat me" signal for phagocytosis dying cells, which plays a pivotal role in activating immunity. However, there limited knowledge describing effects proton and carbon-ion radiation on ecto-CRT exposure. Hence, we...
ABSTRACT Objective Reverse obliquity intertrochanteric fracture is an unstable type of fracture. Current guidelines recommend intramedullary fixation, but there are still complications such as screw removal, hip varus, nail withdrawal, and The objective this study was to use finite element analysis compare the biomechanical properties novel proximal femoral bionic (PFBN), antirotation (PFNA), combined compression interlocking (InterTan) in treatment reverse fractures (AO/OTA 31‐A3.1)....
Esophageal squamous cell carcinoma (ESCC), the most common type of esophageal cancer, characterized by low five-year survival rate, and concurrent chemoradiotherapy (CCRT) has been proposed to treat ESCC, while potential biomarkers for prognostic monitoring after optimized CCRT remains unknown. Serum samples from 45 patients with ESCC were collected categorized into three groups: Control (pre-CCRT), (during CCRT), CCRT-1 M (one-month post-CCRT). The therapeutic effect was evaluated using CT...
Eleven new monoterpenes, paeonidangenin (1), paeonidanin A (2), B (3), C (4), D (5), E (6), paeoniflorone (7), 4-O-methylbenzoylpaeoniflorin (8), 4-O-methylgalloylpaeoniflorin (9), 4-O-methyldebenzoylpaeoniflorin (10), and 4-O-methylalbiflorin (11), were isolated from the 60% ethanol extract of roots Paeonia albiflora. Their structures determined primarily on basis 1D 2D NMR techniques MS studies. Paeonidanins (5) (6) are unprecedented examples "cage-like" monoterpene dimers. The inhibitory...
Abstract Cisplatin (DDP) based chemotherapy occurs a reduced therapeutic effect on the later treatment of ovarian cancer (OC) due to DDP resistance. Astragaloside II (ASII), natural product extracted from Radix Astragali , has shown promising anticancer effects. However, effects ASII OC have not been clarified. In this study, we found that inhibited cell growth and promoted apoptosis DDP‐resistant cells in vitro vivo. Further study showed downregulated multidrug resistance‐related protein...
Long non-coding RNAs (lncRNAs) play vital roles in the metastasis and invasion of cancer cells. Systematic analysis ovarian (OvCa) expression profiles suggests that deregulation lncRNA AC004988.1, designated promoting transition-associated (PTAL), is involved OvCa progression. However, underlying mechanism PTAL remains unknown. In this study, we showed was significantly upregulated mesenchymal subtype samples compared with epithelial from TCGA serous datasets. positively correlated...
The effects of immunomodulatory activity two types carboxymethyl pachymaran (CMP-1 and CMP-2) on cyclophosphamide (CTX)-induced mice were investigated. Both CMP-1 CMP-2 found to restore the splenomegaly alleviate spleen lesions mRNA expressions TLR4, MyD88, p65 NF-κB in also increased. could enhance immunity by increasing levels TNF-α, IL-2, IL-6, IFN-γ, Ig-A Ig-G serum. In addition, increase relative abundance Bacteroidetes reduce richness Firmicutes at phylum level. Erysipelatoclostridum...
Esophageal squamous cell carcinoma (ESCC), the most common pathological type of esophageal cancer, is one leading causes cancer death worldwide, but an effective therapeutic avenue still absent. This study was to evaluate effect Agaricus blazei Murrill polysaccharides (ABP) and Enteromorpha prolifera (EP) on ESCC. The results showed that both ABP EP have effects multiple malignant processes ESCC, such as proliferation, migration, invasion, apoptosis, in vitro. Moreover, retard tumor growth...
In both Caenorhabditis elegans and Drosophila , UNC-73/Trio functions in axon guidance by signaling through the Rac GTPase to regulate cytoskeletal rearrangements necessary for growth cone migrations. Here, we show that complex C. unc-73 gene encodes at least eight differentially expressed UNC-73 intracellular protein isoforms. Previously reported mutations affecting isoforms encoding Rac-specific RhoGEF-1 domain cause uncoordinated movement, correlating with defects guidance. Mutations...
This study aims to investigate the effects of exogenous catalase (CAT), an antioxidative enzyme from microbial cultures, on intestinal development and microbiota in weaned piglets. Seventy-two piglets were allotted two groups fed a basal diet or containing 2.0 g/kg CAT. Results showed that CAT increased (p < 0.05) jejunal villus height/crypt depth ratio factors (diamine oxidase transforming growth factor-α) concentration. Moreover, dietary supplementation enhanced capacity, decreased...
Hypoxia is a hallmark of cancer that may contribute to an immunosuppressive microenvironment and promote radioresistance. High linear energy transfer (LET) radiation considered be able overcome the negative effects hypoxia. However, anti-tumorigenic induced by low or high LET have not been fully elucidated. This study aimed compare different types on immune response, particularly impact calreticulin (CRT), programmed cell death ligand 1 (PDL1) expression.Four human tumor lines were...
Esophageal squamous cell carcinoma (ESCC) may be correlated with HPV infection, and the mechanism underlying ESCC formation induced by HPV16 infection remains elusive. Here, we overexpressed E6 E7 coordinated overexpression of these two genes in EPC2 cells. We found that expression promoted proliferation cells, upregulation shh was responsible for since use vismodegib led to failure organoid formation. Meanwhile, cells proliferation, migration, invasion vitro. Importantly, coordinately...