A5029878935- MicroRNA in disease regulation
- Liver physiology and pathology
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cancer Cells and Metastasis
- Pancreatic and Hepatic Oncology Research
- Ubiquitin and proteasome pathways
- Organ Transplantation Techniques and Outcomes
- Extracellular vesicles in disease
- Liver Disease and Transplantation
- Cancer Mechanisms and Therapy
- Cancer, Hypoxia, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ferroptosis and cancer prognosis
- Transplantation: Methods and Outcomes
- Nanoplatforms for cancer theranostics
- Autophagy in Disease and Therapy
- Natural product bioactivities and synthesis
- FOXO transcription factor regulation
- Epigenetics and DNA Methylation
- Clinical Nutrition and Gastroenterology
- Drug Transport and Resistance Mechanisms
- Sphingolipid Metabolism and Signaling
- Cancer Research and Treatments
- PI3K/AKT/mTOR signaling in cancer
Nanjing University
2011-2025
Nanjing Drum Tower Hospital
2015-2025
Shandong University
2025
Second Affiliated Hospital of Fujian Medical University
2025
Nanjing Medical University
2009-2023
Nanjing University of Chinese Medicine
2012-2023
Sichuan Agricultural University
2022-2023
Shandong Maternal and Child Health Hospital
2022
North Sichuan Medical University
2017
Jiangsu Province Hospital
2016
Exosomes are carriers of intercellular information and regulate the tumor microenvironment. They play an important role in drug resistance by transporting RNA molecules proteins. However, their effects on sorafenib hepatocellular carcinoma (HCC) not completely understood.Exosomes were isolated from two invasive hepatoma cell lines (MHCC-97 L MHCC-97H), roles regulating liver cancer cells as well underlying molecular mechanisms determined. The exosomes analyzed TEM (transmission electron...
Recent studies have shown that circulating microRNAs are potential biomarkers for various types of malignancies. The aim this study was to investigate the feasibility using serum exosomal (miRNAs) as novel serological hepatocellular carcinoma (HCC) diagnosis and prognosis. Exosomes small membranous vesicles (30-100 nm). Exosomal miR-665 levels in HCC patients were significantly higher than those healthy subjects (P < 0.05), upregulated tumours larger size (> 5 cm), with local invasion at an...
Pathogenic factors driving obesity to type 2 diabetes (T2D) are not fully understood. Group 1 innate lymphoid cells (ILC1s) effectors of immunity and enriched in inflamed tissues. Here we show that the number adipose ILC1s increases obese T2D patients correlates with glycemic parameters blood; circulating ILC1 numbers decrease as a result metabolic improvements after bariatric surgery. In vitro co-culture experiments human promote fibrogenesis CD11c+ macrophage activation. Reconstruction...
The liver has great regenerative capacity after functional mass loss caused by injury or disease. Many studies have shown that primary hepatocyte-derived exosomes, which can deliver biological information between cells, promote the process of liver. However, yield exosomes is very limited. Recent demonstrated exosome-mimetic nanovesicles (NVs) be prepared from cells with almost 100 times production compared exosomes. Thus, this study investigated therapeutic NVs hepatocytes in regeneration....
Abstract IQ motif-containing GTPase-activating protein 1 (IQGAP1) is a scaffold that participates in several cellular functions, including cytoskeletal regulation, cell adhesion, gene transcription and polarization. IQGAP1 has been implicated the tumorigenesis progression of human cancers. However, role pancreatic ductal adenocarcinoma (PDAC) still unknown. We found expression was an independent prognostic factor for PDAC. upregulation significantly promoted proliferation, migration,...
Abstract The early detection of cancers can significantly change outcomes even with existing treatments. However, ~50% still cannot be detected until they reach an advanced stage, highlighting the great challenges in detection. Here, ultrasensitive deep near‐infrared (dNIR) nanoprobe that is successively responsive to tumor acidity and hypoxia reported. It demonstrated new specifically detects microenvironment based on NIR imaging ten different types models using cancer cell lines...
Purpose . Tumor microenvironment confers drug resistance to kinase inhibitors by increasing RKT ligand levels that result in the activation of cell-survival signaling including PI3K and MAPK signals. We assessed whether HSC-LX2 coculture conferred sorafenib Huh7 revealed mechanism underlying resistance. Experimental Design The effect LX2 on was determined system with cells. rescue function supernatants MTT assay fluorescence microscopy. tested administration pathway manifested Western...
Oncolytic adenoviruses are among the most widely utilized oncolytic viruses due to their notable anti-tumor and gene expression capabilities, modification of ADVs create armed remains a popular research direction. Nonetheless, immune suppression triggered by ADV targeted enhancements based on this limitation have been relatively unexplored. Flow cytometry was employed assess infiltration in tumor microenvironment following therapy. Targeted novel recombinant viruses, ADVNE ADVPPE, were...
AIM:To investigate the effects of tectorigenin on human hepatocellular carcinoma (HCC) HepG2 cells.METHODS: Tectorigenin, one main components rhizome Iris tectorum , was prepared by simple methods, such as extraction, filtration, concentration, precipitation and recrystallization.HepG2 cells were incubated with at different concentrations, their viability assessed 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.Apoptosis detected morphological observation nuclear change,...
Ubiquitin specific protease 39 (USP39) plays an important role in mRNA splicing. In the present study, we investigated of USP39 regulating growth hepatocellular carcinoma (HCC). We detected expression more than 100 HCC clinical samples. The was significantly higher tumor tissues compared to adjacent normal tissues, and strongly associated with pathological grade HCC. knockdown inhibited cell proliferation colony formation vitro HepG2 cells, while upregulation promoted growth. FCM assay...
Background: Regorafenib is a second-line therapy drug used for advanced hepatocellular carcinoma (HCC). Unfortunately, the survival benefit of patients receiving this treatment modest, which may be attributed to resistance. In present study, Sphingosine kinase 2 (SphK2) was targeted reverse regorafenib-resistance in HCC. Methods: The function SphK2 and sphingosine-1-phosphate (S1P), catalytic product HCC cells were evaluated by cell counting kit-8 assay, colony formation, cycle evaluation...
Colorectal cancer (CRC) is one of the most lethal cancers. Single-cell RNA sequencing (scRNA-seq) and protein-protein interactions (PPIs) have enabled systematic study CRC. In our research, activation AKT pathway in CRC was analyzed by KEGG using single-cell data from GSE144735 dataset. The correlation PPIs MDFI ITGB4/LAMB3 were examined. results verified TCGA CCLE further tested coimmunoprecipitation experiments. effect on via validated knockdown lentiviral overexpression...