A5079257899- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Angiogenesis and VEGF in Cancer
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Liver physiology and pathology
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Ubiquitin and proteasome pathways
- Circular RNAs in diseases
- Organ Transplantation Techniques and Outcomes
- RNA modifications and cancer
- Extracellular vesicles in disease
- Autophagy in Disease and Therapy
- Cancer Cells and Metastasis
- Cell death mechanisms and regulation
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Clinical Nutrition and Gastroenterology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related Molecular Pathways
- Tissue Engineering and Regenerative Medicine
- FOXO transcription factor regulation
- RNA Research and Splicing
- Peptidase Inhibition and Analysis
Nanjing University
2007-2025
Nanjing Medical University
2008-2025
Nanjing General Hospital of Nanjing Military Command
2025
Jiangsu Province Hospital
2016-2025
Shandong University
2025
Shandong Provincial Hospital
2025
Shandong First Medical University
2025
Ministry of Education of the People's Republic of China
2025
Shougang (China)
2025
Fudan University
2024
BackgroundHepatocellular carcinoma (HCC) is an aggressive malignant disease with poor prognosis. Recent advances suggest the existence of cancer stem cells (CSCs) within liver cancer, which are considered to be responsible for tumor relapse, metastasis, and chemoresistance. However, novel therapeutic approaches eradicating CSCs yet established. Here, we aimed identify role glutaminase 1 (GLS1) in stemness, feasibility that GLS1 serves as a target elimination well possible...
Recently, long non-coding RNAs (lncRNAs) are identified as new crucial regulators of diverse cellular processes, including cell proliferation, differentiation and cancer cells metastasis. Accumulating evidence has revealed that aberrant lncRNA expression plays important roles in carcinogenesis tumor progression. However, the pattern biological function lncRNAs non-small-cell lung (NSCLC) remain largely unknown. In this study, we performed comprehensive analysis human NSCLC samples by using...
A unique approach using the large photoacoustic effect of single-walled carbon nanotubes (SWNTs) for targeting and selective destruction cancer cells is demonstrated. SWNTs exhibit a in suspension under irradiation 1064-nm Q-switched millisecond pulsed laser trigger firecracker-like explosion at nanoscale. By such an explosion, agent developed by functionalizing with folate acid (FA) that can selectively bind to overexpressing receptor on surface cell membrane kill them through SWNT inside...
Exosomes are carriers of intercellular information and regulate the tumor microenvironment. They play an important role in drug resistance by transporting RNA molecules proteins. However, their effects on sorafenib hepatocellular carcinoma (HCC) not completely understood.Exosomes were isolated from two invasive hepatoma cell lines (MHCC-97 L MHCC-97H), roles regulating liver cancer cells as well underlying molecular mechanisms determined. The exosomes analyzed TEM (transmission electron...
Abstract Aim Hepatic tissue engineering is considered as a possible alternative to liver transplantation for end‐stage disease. Several methods of decellularization xenogeneic are available produce three‐dimensional organ scaffolds tissues. However, rare studies have examined and compared the effectiveness different on structure composition intact decellularized extracellular matrix. Methods Two were adopted herein. Their effects collagen, elastin, glycosaminoglycans ( GAG s), hepatocyte...
Recent studies have shown that circulating microRNAs are potential biomarkers for various types of malignancies. The aim this study was to investigate the feasibility using serum exosomal (miRNAs) as novel serological hepatocellular carcinoma (HCC) diagnosis and prognosis. Exosomes small membranous vesicles (30-100 nm). Exosomal miR-665 levels in HCC patients were significantly higher than those healthy subjects (P < 0.05), upregulated tumours larger size (> 5 cm), with local invasion at an...
Aim Recently, the benefit of mesenchymal stem cells (MSCs) as a cell‐based therapy for acute liver failure (ALF) has gained much attention, although mechanism action MSCs in treatment ALF remains elusive. Pyroptosis is novel form programmed cell death with an intense inflammatory response. The aim present study was to explore soluble cytokines secreted by and their therapeutic effects through inhibiting pyroptosis ALF. Methods Mesenchymal obtained from C57BL/6 mice were isolated cultured...
Abstract Hepatocellular carcinoma (HCC) is the leading cause of cancer-related death worldwide, because recurrence often occurs in most HCC patients undergoing hepatectomy. It necessary to identify with high risk for and adopt effective therapies. An obstacle monitor at poor prognosis has been lack useful predictive biomarkers. Fortunately, recent progress system biology allows screen biomarkers a high-throughput manner. In this study, we performed systematic Kaplan-Meier survival analysis...
Abstract Purpose: To investigate the distribution, frequency, and clinical significance of mobilized endothelial progenitor cells (EPC) in hepatocellular carcinoma (HCC). Experimental Design: In healthy controls patients with HCC, frequency circulating EPCs was determined by colony-forming assays, fluorescence-activated cell sorting, real-time PCR. One hundred sixty-five–amino acid form vascular growth factor platelet-derived factor-BB plasma tissue were quantified ELISA. The distribution...
Purpose . Tumor microenvironment confers drug resistance to kinase inhibitors by increasing RKT ligand levels that result in the activation of cell-survival signaling including PI3K and MAPK signals. We assessed whether HSC-LX2 coculture conferred sorafenib Huh7 revealed mechanism underlying resistance. Experimental Design The effect LX2 on was determined system with cells. rescue function supernatants MTT assay fluorescence microscopy. tested administration pathway manifested Western...
Breast cancer susceptibility gene 1 (BRCA1) has a central role in chemotherapy-induced DNA damage response. The protein inhibitor of activated STAT (PIAS) family proteins, PIAS1 and PIAS4, are also necessary for adequate repair. To further understand the BRCA1 repair, we examined mRNA expression these genes 133 advanced (stage III-IV) gastric patients using quantitative reverse transcription polymerase chain reaction. All P values were two-sided. median overall survival was 12.5 months (95%...
Ubiquitin specific protease 39 (USP39) plays an important role in mRNA splicing. In the present study, we investigated of USP39 regulating growth hepatocellular carcinoma (HCC). We detected expression more than 100 HCC clinical samples. The was significantly higher tumor tissues compared to adjacent normal tissues, and strongly associated with pathological grade HCC. knockdown inhibited cell proliferation colony formation vitro HepG2 cells, while upregulation promoted growth. FCM assay...
Abstract Background Circulating cell-free microRNAs have been identified as potential cancer biomarkers. However, the existence and application of miRNAs in effusion samples are still uncertain. In order to explore role miRNA malignant effusions, we selected 22 differentially expressed serum lung patients studied their expression levels body cavity samples. Methods We measured using qRT-PCR two samples, which were pooled with 18 12 benign respectively. After discarding 9 lowly miRNAs, a...
The effect of parenteral nutrition (PN) support supplemented with ω-3 fatty acids was investigated in a randomized, controlled clinical trial at the Affiliated Drum Tower Hospital, Medical School Nanjing University.