Astrocytes actively participate in energy metabolism the brain, and astrocytic aerobic glycolysis disorder is associated with pathology of Alzheimer's disease (AD). GLP-1 has been shown to improve cognition AD; however, mechanism remains unclear. The objectives this study were assess GLP-1's glycolytic regulation effects AD reveal its neuroprotective mechanisms. Morris water maze test was used evaluate liraglutide (an analog GLP-1) on 4-month-old 5×FAD mice, a proteomic analysis Western...

Abstract Background Establishing whether there is a potential relationship between glucagon-like peptide 1 receptor agonists (GLP-1RAs) and suicidal or self-injurious behaviors (SSIBs) crucial for public safety. This study investigated the association GLP-1RAs SSIBs by exploring FDA Adverse Event Reporting System (FAERS) database. Methods A disproportionality analysis was conducted using post-marketing data from FAERS repository (2018 Q1 to 2022 Q4). SSIB cases associated with were...

Abstract Remaining useful fatigue life monitoring of wind turbine drivetrains is important. However, the implementation real‐time often faces efficiency and accuracy challenges. In order to resolve this, this paper proposes a vibration‐based damage digital twin (VBDM‐DT) that enables online intelligent evaluation gearboxes, using gear tooth surface durability as an example mode. The VBDM‐DT integrates random load model, high‐fidelity dynamics model. model takes speed from supervisory control...

Abstract Purpose: To investigate the distribution, frequency, and clinical significance of mobilized endothelial progenitor cells (EPC) in hepatocellular carcinoma (HCC). Experimental Design: In healthy controls patients with HCC, frequency circulating EPCs was determined by colony-forming assays, fluorescence-activated cell sorting, real-time PCR. One hundred sixty-five–amino acid form vascular growth factor platelet-derived factor-BB plasma tissue were quantified ELISA. The distribution...

Triazole antifungal drugs (TAD) are widely used to treat invasive fungal infections due their broad spectrum and low toxicity. Despite preference in the clinic, multiple Adverse Events (AE) still reported each year. Objective: We aimed characterize distribution of associated with different systems identify Important Medical (IME) signals for drugs. Methods: The U.S. Food Drug Administration Event Reporting System (FAERS) was queried related from 2012 2022. caused by all other non-TAD were...

ABSTRACT The stability of prediction precision under complex loading paths is one the key challenges in task multiaxial fatigue life prediction. This study addresses unstable machine learning models, while further improving A novel neural network based on a transformer framework proposed to capture dependencies between data at multiple scales. Meanwhile, physical loss function with soft adjustments add constraints network. These two mechanisms assist each other accuracy and Performance...

Abstract This study utilized model‐based meta‐analysis (MBMA) to systematically assess the efficacy of methotrexate (MTX) monotherapy in improving rheumatoid arthritis (RA) symptoms and function. The assessment was based on indicators such as Disease Activity Score 28 (DAS28), Health Assessment Questionnaire, American College Rheumatology (ACR) criteria. Additionally, investigated impact dosage, disease duration, serum markers—C‐reactive protein (CRP) erythrocyte sedimentation rate (ESR)—on...

A digital twin for a wind turbine gearbox (WTG-DT) is essential advancing farm intelligence and improving the efficiency of operation. This study addresses key limitations existing condition monitoring systems, such as low accuracy slow parameter updates, by proposing long short-term memory (LSTM) network to intelligently calibrate model parameters. ensures real-time operation maintenance turbines. high-fidelity dynamic developed validated performing frequency analysis vibration signals...

Lenvatinib is a medication that targets multiple tyrosine kinases and commonly used to treat various types of cancer. With its frequent usage, monitoring assessing potential adverse effects has become crucial. This study utilizes the US Food Drug Administration Adverse Event Reporting System (FAERS) database analyze possible link between lenvatinib gastrointestinal perforation. FAERS was drug reactions (ADRs) linked with from first quarter 2015 last 2022. The association perforation...

Patients with epilepsy often require long-term use of antiseizure medications (ASMs) to control their seizures. However, movement disorders (MDs) related ASMs can significantly impact quality life. This study aims analyse MDs in the Food and Drug Administration Adverse Event Reporting System database provide recommendations for safe medication.All adverse drug reactions associated 26 marketed were extracted analysis. Disproportionality analyses used assess association between MDs, signal...

The use of (GLP-1 RAs) among pregnant women is escalating, yet safety data remain insufficient. This study aims to comprehensively assess adverse drug reactions (ADRs) associated with GLP-1 RAs in using the US Food and Drug Administration Adverse Event Reporting System (FAERS) database.

Background: A growing body of evidence indicates a strong association between exogenous thyroid hormone (ETH) and brain health. Establishing the potential relationship ETH therapy dementia symptoms is crucial for patients with disorders. Objective: In this study, we investigate by exploring Food Drug Administration Adverse Event Reporting System (FAERS) database. Methods: Disproportionality analysis (DPA) was conducted using postmarketing data from FAERS repository (Q1 2004 to Q4 2023)....

To recommend precision dosing and improve therapeutic efficacy against invasive fungal disease, a physiologically based pharmacokinetic model (PBPK) of oral isavuconazole (ISA) was established used to explore its disposition across populations in different physiological pathological states.

Alzheimer's disease (AD) is a neurodegenerative condition leading to memory loss, cognitive impairment, and neuropsychiatric symptoms. Second-generation antipsychotics (SGAs) are commonly used manage these symptoms, but their safety profile in patients with AD requires further investigation.

In order to explore the influence of laser power on evolution molten pool and convective heat transfer cladding Incoloy 926 stainless steel surface, a three-dimensional thermal fluid multi-field coupled numerical model was established in this paper. The variation latent during solid-liquid phase transformation treated by apparent capacity method. change gas–liquid interface tracked using mesh growth method real time. instantaneous temperature field velocity flow surface under different...

The effect of dynamic performance shall be considered when calculating the wind speed relative to turbine structure, since it is essential prolong its service life. This article presents a method get responses under different conditions. time-varying load acting on blade calculated by using element momentum theory, and are applying modal superposition with loads as excitations. A platform constructed experimentally test system. response process adopted carry out analysis, theoretical results...

Abstract Therapeutic drug monitoring (TDM) of busulfan (BU) is currently performed by plasma sampling in patients undergoing hematopoietic stem cell transplantation (HSCT). Saliva samples are considered a noninvasive TDM matrix. Currently, no salivary population pharmacokinetics (PopPKs) model for BU available. This study aimed to develop PopPK that can describe the relationship between and saliva kinetics receiving intravenous BU. The performance predicting area under concentration‐time...

Objectives: To achieve the AUC-guided dosing, we proposed three methods to estimate polymyxin B AUC across 24 h at steady state (AUCSS,24h) using limited concentrations after its first dose.

Abstract This paper proposed a numerical strategy which could achieve the coupled modeling and solving of transpiration cooling with external high-temperature gas flow especially take radiation effect into account. Based on strategy, heat mass transfer characteristics in channel were studied, corresponding influence factors analyzed. The results indicated that radiative flux takes an important role between may reach 40% under operating condition considered this work, absorption from coolant...