A5033623201- Liver Disease Diagnosis and Treatment
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Diabetes Management and Research
- Pancreatic function and diabetes
- Adipokines, Inflammation, and Metabolic Diseases
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipid metabolism and disorders
- Diabetes and associated disorders
- Pluripotent Stem Cells Research
- Peroxisome Proliferator-Activated Receptors
- Growth Hormone and Insulin-like Growth Factors
- Cardiovascular Disease and Adiposity
- Pregnancy and preeclampsia studies
- Ovarian function and disorders
- Plant-Microbe Interactions and Immunity
- Extracellular vesicles in disease
- Gestational Diabetes Research and Management
- Bariatric Surgery and Outcomes
- Pain Mechanisms and Treatments
- Neurological Disease Mechanisms and Treatments
- Heart Rate Variability and Autonomic Control
Nanjing Drum Tower Hospital
2016-2025
National Clinical Research Center for Digestive Diseases
2023-2025
International Peace Maternity & Child Health Hospital
2024-2025
Changchun University of Chinese Medicine
2025
Nanjing Medical University
2012-2024
Huazhong University of Science and Technology
2013-2024
Shanghai Jiao Tong University
2013-2024
Zhejiang University
2011-2024
Lanzhou University Second Hospital
2024
Nanjing University of Chinese Medicine
2024
NAC (NAM, ATAF and CUC) transcriptional factors constitute a large family with more than 150 members in rice several of this have been demonstrated to play crucial roles abiotic stress response. In the present study, we report function novel stress-responsive gene, ONAC066, drought oxidative tolerance. ONAC066 was localized nuclei cells when transiently expressed Nicotiana benthamiana is transcription activator binding ability recognition sequence (NACRS) AtJUB1 site (JBS). Expression...
The aim of the present study was to compare effects gliclazide, liraglutide, and metformin in type 2 diabetes mellitus (T2DM) patients with non-alcoholic fatty liver disease (NAFLD).Eighty-seven subjects were randomized receive metformin, or gliclazide for 24 weeks. Primary outcomes included HbA1c levels, intrahepatic fat (IHF) content, function.Both levels IHF content reduced after treatment all three groups. However, lower liraglutide- metformin-treated groups than gliclazide-treated...
To compare the effects of gliclazide, liraglutide and metformin on body composition in patients with type 2 diabetes mellitus non-alcoholic fatty liver disease.A total 85 were randomly allocated to receive gliclazide (n = 27), 29) or monotherapy for 24 weeks. Body was measured using dual-energy X-ray absorptiometry.Liraglutide reduced total, trunk, limb, android gynoid fat mass; this also led weight reduction. However, treatment produced no significant changes mass, likely because reductions...
Pathogenic factors driving obesity to type 2 diabetes (T2D) are not fully understood. Group 1 innate lymphoid cells (ILC1s) effectors of immunity and enriched in inflamed tissues. Here we show that the number adipose ILC1s increases obese T2D patients correlates with glycemic parameters blood; circulating ILC1 numbers decrease as a result metabolic improvements after bariatric surgery. In vitro co-culture experiments human promote fibrogenesis CD11c+ macrophage activation. Reconstruction...
OBJECTIVE Large numbers of people with type 2 diabetes are obese. However, changes in cognition and related brain function obese have not been characterized. Here, we investigated cognition, olfactory function, odor-induced alterations these patients therapeutic effects glucagon-like peptide 1 receptor agonists (GLP-1Ras) on their psychological behavior networks. RESEARCH DESIGN AND METHODS Cognitive, olfactory, activation assessments were administered to 35 nonobese control subjects matched...
Abstract Objective The objective of this study was to investigate underlying mechanisms long‐term effective weight loss after laparoscopic sleeve gastrectomy (LSG) and effects on the medial orbitofrontal cortex (mOFC) cognition. Methods A total 18 individuals with obesity (BMI ≥ 30 kg/m 2 ) underwent LSG. Clinical data, cognitive scores, brain magnetic resonance imaging scans were evaluated before LSG 12 months We employed voxel‐based morphometry analysis seed‐based resting‐state functional...
To examine the effect of intensive glycemic control therapy (IT) on insulin sensitivity and β-cell function in newly diagnosed type 2 diabetic patients compared with subjects normal glucose tolerance (NGT) those impaired (IGT).Forty-eight were randomly assigned to IT for weeks followed up 1 year. Intravenous tests conducted NGT, IGT, subjects. Blood measured before after at 1-year follow-up.IT lowered homeostasis model assessment (HOMA) resistance (IR) significantly, from 3.12 ± 1.4 (mean...
Abstract Podocyte injury and the appearance of proteinuria are features minimal-change disease (MCD). Cyclosporin A (CsA) tacrolimus (FK506) has been reported to reduce in patients with nephrotic syndrome, but mechanisms remain unknown. We, therefore, investigated protective CsA FK506 on a rat model MCD induced by puromycin aminonucleoside (PAN) vitro cultured mouse podocytes. Our results showed that treatment decreased via mechanism associated reduction foot-process fusion desmin, recovery...
Background: Previous studies show that the use of do-it-yourself artificial pancreas system (DIYAPS) may be associated with better glycemic control characterized by improved estimated hemoglobin A1c (eHbA1c) and time in range among adults type 1 diabetes (T1D). However, few have demonstrated changes laboratory-measured HbA1c, which is a more accepted index for control, after using DIYAPS. Methods: This retrospective before-after study approaching patients who reported self-use AndroidAPS....
Abstract Background The preservation or restoration of β cell function in type 1 diabetes (T1D) remains as an attractive and challengeable therapeutic target. Mesenchymal stromal cells (MSCs) are multipotent with high capacity immunoregulation, which emerged a promising cell-based therapy for many immune disorders. objective this study was to examine the efficacy safety one repeated transplantation allogeneic MSCs individuals T1D. Methods This nonrandomized, open-label, parallel-armed...
OBJECTIVE The comparative neuroprotective effects of different antidiabetes drugs have not been characterized in randomized controlled trials. Here, we investigated the therapeutic liraglutide, dapagliflozin, or acarbose treatment on brain functional alterations and cognitive changes patients with type 2 diabetes. RESEARCH DESIGN AND METHODS Thirty-six diabetes inadequately metformin monotherapy were to receive for 16 weeks. Brain MRI (fMRI) scan a battery assessments evaluated pre-...
NAC transcription factors (TFs) play critical roles in plant immunity by modulating the expression of downstream genes via binding to specific cis-elements promoters. Here, we report function and regulatory network a pathogen- defense phytohormone-inducible TF gene, ONAC083, rice (Oryza sativa) immunity. ONAC083 localizes nucleus exhibits transcriptional activation activity that depends on its C-terminal region. Knockout enhances against Magnaporthe oryzae, strengthening pathogen-induced...
Although cognitive impairment in nonalcoholic fatty liver disease (NAFLD) has received attention recent years, little is known about detailed functions histologically diagnosed individuals.This study aimed to investigate the association of pathological changes with features and further explore underlying brain manifestations.We performed a cross-sectional 320 subjects who underwent biopsy. Among enrolled participants, 225 assessments global cognition subdomains. Furthermore, 70 individuals...
Pancreatic β-cell dysfunction caused by obesity can be associated with alterations in the levels of miRNAs. However, role miRNAs such processes remains elusive. Here, we show that pancreatic islet miR-27a-5p, which is markedly increased obese mice and impairs insulin secretion, mainly delivered visceral adipocyte–derived extracellular vesicles (EVs). Depleting miR-27a-5p significantly improved secretion glucose intolerance db/db mice. Supporting function EV as a key pathogenic factor,...
Recent studies have shown placenta-derived exosome (pdE) acts as an important mediator of organ-to-organ interplay regulating maternal metabolic alterations, however, the function and mechanisms placental exosomes on pancreatic β-cell maladaptation in gestational diabetes mellitus (GDM) remain unclear. The purpose this investigation was to ascertain how affected dysfunction associated with onset GDM. Exosomes were isolated from chorionic villi explants pregnant mice humans normal glucose...