A5044071212- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Crystallography and molecular interactions
- Organometallic Complex Synthesis and Catalysis
- Drug-Induced Hepatotoxicity and Protection
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- interferon and immune responses
- Hepatocellular Carcinoma Treatment and Prognosis
- Pharmacological Effects of Natural Compounds
- Coordination Chemistry and Organometallics
- Circular RNAs in diseases
- Plant-based Medicinal Research
- Cancer Mechanisms and Therapy
- Synthesis and characterization of novel inorganic/organometallic compounds
- Autophagy in Disease and Therapy
- Magnetism in coordination complexes
- Viral Infections and Vectors
- Advanced biosensing and bioanalysis techniques
- Peptidase Inhibition and Analysis
- Chemotherapy-induced organ toxicity mitigation
- Metalloenzymes and iron-sulfur proteins
Nanjing Drum Tower Hospital
2014-2024
Chinese PLA General Hospital
2021-2024
Nanjing University
2011-2024
Gannan Normal University
2024
National Institute for Occupational Health and Poison Control
2024
Yancheng Institute of Technology
2024
Nanjing University of Chinese Medicine
2023
Nanjing Medical University
2022
Gansu Provincial Hospital of TCM
2009-2019
First Affiliated Hospital of Xi'an Jiaotong University
2019
Abstract Background and Aim Chinese herbal medicine (CHM), as well Western (WM), is an important cause of drug‐induced liver injury (DILI). However, the differences between CHM WM agents implicated in have rarely been reported. Methods Overall, 1985 (2.05%) DILI cases were retrospectively collected from 96 857 patients hospitalized because dysfunction 302 Military Hospital January 2009 2014. Results In all enrolled with DILI, was 563 (28.4%), while 870 (43.8%) caused by remaining (27.8%)...
The liver has great regenerative capacity after functional mass loss caused by injury or disease. Many studies have shown that primary hepatocyte-derived exosomes, which can deliver biological information between cells, promote the process of liver. However, yield exosomes is very limited. Recent demonstrated exosome-mimetic nanovesicles (NVs) be prepared from cells with almost 100 times production compared exosomes. Thus, this study investigated therapeutic NVs hepatocytes in regeneration....
Background . Hepatocellular carcinoma (HCC) remains a disastrous disease and the treatment for HCC is rather limited. Separation identification of active compounds from traditionally used herbs in may shed light on novel therapeutic drugs HCC. Methods Cell viability colony forming assay were conducted to determine anti-HCC activity. Morphology cells activity caspases analyzed. Antiapoptotic Bcl-2 family proteins JNK also examined. Levels unfolded protein response (UPR) markers determined...
Abstract The early detection of cancers can significantly change outcomes even with existing treatments. However, ~50% still cannot be detected until they reach an advanced stage, highlighting the great challenges in detection. Here, ultrasensitive deep near‐infrared (dNIR) nanoprobe that is successively responsive to tumor acidity and hypoxia reported. It demonstrated new specifically detects microenvironment based on NIR imaging ten different types models using cancer cell lines...
Purpose . Tumor microenvironment confers drug resistance to kinase inhibitors by increasing RKT ligand levels that result in the activation of cell-survival signaling including PI3K and MAPK signals. We assessed whether HSC-LX2 coculture conferred sorafenib Huh7 revealed mechanism underlying resistance. Experimental Design The effect LX2 on was determined system with cells. rescue function supernatants MTT assay fluorescence microscopy. tested administration pathway manifested Western...
Abstract Designing dynamic assemblies in living cells is crucial for creating organelle‐like structures, yet precisely controlling their morphological transitions response to specific signals a significant challenge. In this study, DNA framework combined with hybridization chain reaction (HCR) achieve assembly of hyperbranched aggregates cancer cells. HCR, distinguished its signal amplification and linear extension capabilities, enables the transition precursors be specifically triggered by...
With the advancing comprehension of immunology, an increasing number immunotherapies are being explored and implemented in field cancer treatment. The cGAS-STING pathway, a crucial element innate immune response, has been identified as pivotal immunotherapy. We evaluated antitumor effects
Background. Despite improvement in treatment, the prognosis of hepatocellular carcinoma (HCC) remains disastrous. Cancer stem cells (CSCs) may be responsible for cancer malignant behaviors. ATP-binding cassette, subfamily G, member 2 (ABCG2) is widely expressed both normal and play an important role Methods. The expression ABCG2 HCC tissues SMMC-7721 was examined, relevance with clinical characteristics analyzed. ABCG2+ ABCG2- were sorted, potential tumorigenicity determined. Expression...
Lithiation of R2P(CH2C9H6N-8)NBut (R = Ph, 3; R Pri, 4) with an equivalent BunLi afforded lithium iminophosphorano(8-quinolyl)methanide [Li{CH(8-C9H6N)P(Ph2)NBut}(THF)] (5) and [Li{CH(8-C9H6N)P(Pri2)NBut}]2 (6), respectively. Reaction 4 Et2Mg yielded magnesium complex (7). Treatment 6 ZnCl2 gave [Zn(Cl){CH(8-C9H6N)P(Pri2)NBut}] (8), which was transformed into alkylated zinc complexes [Zn(R1){CH(8-C9H6N)P(Pri2)NBut}] (R1 9; R1 Me, 10) by treating R1Li or R1MgX. Ethylzinc...
Abstract Background The cGAS-STING signaling pathway is an essential section of the natural immune system. In recent years, increasing number studies have shown a strong link between abnormal activation pathway, mediated by nucleic acid receptor cGAS, and development progression autoimmune diseases. Therefore, it important to identify effective compound specifically downregulate this for disease. Methods effect Glabridin (Glab) was investigated in BMDMs Peripheral blood mononuclear cell...
It is being increasingly reported that the Cranio Facial Development Protein 1 (CFDP1) plays a significant role in onset and progression of tumors. Nonetheless, underlying mechanisms associated with CFDP1 contribute to hepatocellular carcinoma (HCC) specific biological remain vague.The Gene Expression Omnibus (GEO) database was analyzed obtain gene expression profiles as well matching clinical data HCC patients. The co-expression network developed by means weighted analysis (WGCNA) screen...