A5101922066- Parasites and Host Interactions
- Heavy metals in environment
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Parasite Biology and Host Interactions
- Drug-Induced Hepatotoxicity and Protection
- Liver Disease and Transplantation
- Cancer Mechanisms and Therapy
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Melanoma and MAPK Pathways
- Lymphoma Diagnosis and Treatment
- Protein Kinase Regulation and GTPase Signaling
- Drug Transport and Resistance Mechanisms
- PI3K/AKT/mTOR signaling in cancer
- Viral-associated cancers and disorders
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Cancer-related molecular mechanisms research
- Liver physiology and pathology
- RNA Research and Splicing
- Gastric Cancer Management and Outcomes
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Circular RNAs in diseases
Guangzhou Medical University
2021-2025
Second Affiliated Hospital of Guangzhou Medical University
2025
Hebei University of Technology
2024-2025
Ruijin Hospital
2015-2024
Shanghai Jiao Tong University
2015-2024
Henan Provincial People's Hospital
2007-2024
China Design Group (China)
2023
Institute of Agricultural Resources and Regional Planning
2020-2022
Chinese Academy of Agricultural Sciences
2020-2022
Ministry of Agriculture and Rural Affairs
2021-2022
Pancreatic ductal adenocarcinoma (PDA) is among the most lethal human cancers in part because it insensitive to many chemotherapeutic drugs. Studying a mouse model of PDA that refractory clinically used drug gemcitabine, we found tumors this were poorly perfused and vascularized, properties are shared with PDA. We tested whether delivery efficacy gemcitabine mice could be improved by coadministration IPI-926, depletes tumor-associated stromal tissue inhibition Hedgehog cellular signaling...
Targeted cancer therapies, which act on specific cancer-associated molecular targets, are predominantly inhibitors of oncogenic kinases. While these drugs have achieved some clinical success, the inactivation kinase signaling via stimulation endogenous phosphatases has received minimal attention as an alternative targeted approach. Here, we demonstrated that activation tumor suppressor protein phosphatase 2A (PP2A), a negative regulator multiple proteins, is promising therapeutic approach...
Oncogenic BRAF alleles are both necessary and sufficient for cellular transformation, suggesting that chemical inhibition of the activated mutant protein kinase may reverse tumor phenotype. Here, we report characterization SB-590885, a novel triarylimidazole selectively inhibits Raf kinases with more potency towards B-Raf than c-Raf. Crystallographic analysis revealed SB-590885 stabilizes oncogenic domain in an active configuration, which is distinct from previously reported mechanism action...
The rapamycin-sensitive mammalian target of rapamycin (mTOR) complex 1 (mTORC1) contains mTOR, raptor, mLST8, and PRAS40 (proline-rich Akt substrate 40 kDa). functions as a negative regulator when bound to mTORC1, it dissociates from mTORC1 in response insulin. has been demonstrated be one phosphorylation site, Ser-183, identified. In this study, we used two-dimensional phosphopeptide mapping conjunction with mutational analysis show that addition also phosphorylates Ser-212 Ser-221 assayed...
Macrophages are commonly classified as M1 macrophages or M2 macrophages. The further sub-categorized into M2a, M2b, M2c, and M2d subtypes. M2c subtypes play roles in anti-inflammatory activity, tissue remodeling, type 2 T helper cell (Th2) activation, immunoregulation. Previous studies have shown that macrophage exosomes can affect some disease processes. Exosomes 30-150-nm lipid bilayer membrane vesicles derived from most living cells, with important biological functions. role of preventing...
Abstract Background and Aim Chinese herbal medicine (CHM), as well Western (WM), is an important cause of drug‐induced liver injury (DILI). However, the differences between CHM WM agents implicated in have rarely been reported. Methods Overall, 1985 (2.05%) DILI cases were retrospectively collected from 96 857 patients hospitalized because dysfunction 302 Military Hospital January 2009 2014. Results In all enrolled with DILI, was 563 (28.4%), while 870 (43.8%) caused by remaining (27.8%)...
Most inflammatory bowel disease (IBD) patients are unable to maintain a lifelong remission. Developing novel therapeutic strategy is urgently needed. In this study, we adopt new attenuate colitis using the Escherichia coli Nissle 1917 probiotic strain express schistosome immunoregulatory protein (Sj16) in gastrointestinal tract. The genetically engineered (EcN-Sj16) highly expressed Sj16 tracts of dextran sulfate sodium-induced mice and significantly attenuated clinical activity mice....
mTORC1 contains multiple proteins and plays a central role in cell growth metabolism. Raptor (regulatory-associated protein of mammalian target rapamycin (mTOR)), constitutively binding mTORC1, is essential for activity critical the regulation response to insulin signaling nutrient energy sufficiency. Herein we demonstrate that mTOR phosphorylates raptor vitro vivo. The phosphorylated residues were identified by using phosphopeptide mapping mutagenesis. phosphorylation stimulated inhibited...
Insulin stimulates protein synthesis by promoting phosphorylation of the eIF4E-binding protein, 4EBP1. This effect is rapamycin-sensitive and mediated mammalian target rapamycin (mTOR) complex 1 (mTORC1), a signaling containing mTOR, raptor, mLST8. Here we demonstrate that insulin produces stable increase in kinase activity mTORC1 3T3-L1 adipocytes. The response was associated with marked 4EBP1 binding to raptor mTORC1, it abolished disrupting TOR motif stimulatory effects on both occurred...
Lipin 1 is a bifunctional protein that regulates gene transcription and, as Mg(2+)-dependent phosphatidic acid phosphatase (PAP), key enzyme in the biosynthesis of phospholipids and triacylglycerol. We describe here functional interaction between lipin nuclear factor activated T cells c4 (NFATc4). represses NFATc4 transcriptional activity through protein-protein interaction, present at promoters targets vivo. Catalytically active inactive can suppress activity, this suppression may involve...
We aimed to investigate the expression of microRNA-34a (miR-34a) in human gastric cancer cells and evaluate effects miR-34a, acting via its gene survivin, on cell HGC-27 provide potential new strategies for treating cancer. In vitro cultures lines MGC80-3, HGC-27, NCI-N87, SGC-7901 normal epithelial line GES-1 were established. The miR-34a each was detected using quantitative real-time polymerase chain reaction (qRT-PCR). After transfected with a mimic 48 h, changes levels qRT-PCR. effect...
Exosomes are 30-150 nm small membrane vesicles that released into the extracellular medium via cells function as a mode of intercellular communication. Dendritic cell (DC)-derived exosomes modulate immune responses and prevent development autoimmune diseases. Moreover, Schistosoma japonicum eggs show modulatory effects in mouse model colitis. Therefore, we hypothesized derived from DCs treated with S. soluble antigen (SEA; SEA-treated DC exosomes) would be useful for treating inflammatory...
Research Article27 March 2017Open Access Transparent process Niacin ameliorates ulcerative colitis via prostaglandin D2-mediated D prostanoid receptor 1 activation Juanjuan Li Department of Gastroenterology, Ruijin Hospital affiliated to Shanghai Jiao Tong University School Medicine, Shanghai, China Key Laboratory Food Safety Research, Institute for Nutritional Sciences, Institutes Biological Chinese Academy Search more papers by this author Deping Kong Qi Wang Wei Wu Yanping Tang Tingting...
Background: Epidemiologic studies and animal model experiments have shown that parasites significant modulatory effects on autoimmune disorders, including inflammatory bowel disease (IBD). Recombinant Sj16 (rSj16), a 16-kDa secreted protein of Schistosoma japonicum (S.japonicum) produced by Escherichia coli (E. coli), has been to immunoregulatory in vivo vitro. In this study, we aimed determine the rSj16 dextran sulfate sodium (DSS)-induced colitis. Methods: DSS-induced colitis mice were...
A Chinese medical team managed Ebola virus disease (EVD) patients in Sierra Leone from October 2014 to March 2015 and attended 693 suspected patients, of whom 288 had confirmed disease.A retrospective study was conducted the with disease. Clinical symptoms, manifestations, serum viral load were analyzed compared among different groups for mortality survival time.Among EVD (149 male 139 female, median age 28 years, log 6.68), 98 died, 36 recovered, 154 lost follow-up. Common symptoms fever...