A5100441006- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Antimicrobial Peptides and Activities
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Zebrafish Biomedical Research Applications
- Cancer, Hypoxia, and Metabolism
- Parasites and Host Interactions
- Cancer Research and Treatments
- Wireless Body Area Networks
- IL-33, ST2, and ILC Pathways
- MicroRNA in disease regulation
- Molecular Communication and Nanonetworks
- Immune Response and Inflammation
- Biochemical and Structural Characterization
- Photodynamic Therapy Research Studies
- Pluripotent Stem Cells Research
- Extracellular vesicles in disease
- Photonic Crystals and Applications
- Peptidase Inhibition and Analysis
- Analytical Chemistry and Chromatography
- Immune cells in cancer
- Bluetooth and Wireless Communication Technologies
- Peroxisome Proliferator-Activated Receptors
- Electrochemical sensors and biosensors
Henan Provincial People's Hospital
2016-2025
Zhejiang Ocean University
2024
Henan University of Technology
2012-2024
Northwest A&F University
2024
Zhengzhou University
2019-2024
Ningxia University
2024
Anhui University of Traditional Chinese Medicine
2024
Ludong University
2024
Vision Technology (United States)
2023
Yunnan University
2021-2023
In this work, a simple and label-free electrochemical biosensor is developed for microRNA (miRNA) detection on the basis of an arched probe mediated isothermal exponential amplification reaction (EXPAR). The assembled electrode surface consists two strands that are partially complementary to each other at both ends. target can hybridize with sequence structure, leading cleavage probe. strand fixed self-assembles, in presence hemin, G-quadruplex unit, yielding signals. liberated into solution...
Elucidating the effects of atmospheric nitrogen (N) deposition on fine root dynamics and potential underlying mechanisms is required to understand changes in belowground aboveground carbon storage. However, research these forests has mostly involved direct understory addition N ignored canopy interception processing N. Here, we conducted a field experiment comparing (CAN) with those (UAN) at three N-addition rates (0, 25 50 kg ha-1 yr-1 ) temperate deciduous forest. Fine production biomass...
Exosomes are 30-150 nm small membrane vesicles that released into the extracellular medium via cells function as a mode of intercellular communication. Dendritic cell (DC)-derived exosomes modulate immune responses and prevent development autoimmune diseases. Moreover, Schistosoma japonicum eggs show modulatory effects in mouse model colitis. Therefore, we hypothesized derived from DCs treated with S. soluble antigen (SEA; SEA-treated DC exosomes) would be useful for treating inflammatory...
Background: Epidemiologic studies and animal model experiments have shown that parasites significant modulatory effects on autoimmune disorders, including inflammatory bowel disease (IBD). Recombinant Sj16 (rSj16), a 16-kDa secreted protein of Schistosoma japonicum (S.japonicum) produced by Escherichia coli (E. coli), has been to immunoregulatory in vivo vitro. In this study, we aimed determine the rSj16 dextran sulfate sodium (DSS)-induced colitis. Methods: DSS-induced colitis mice were...
Acacetin, a natural dietary flavonoid abundantly found in acacia honey and citrus fruits, reportedly exerts several biological effects, such as anti-tumor, anti-inflammatory, anti-oxidative effects. However, the effects of acacetin on intestinal inflammation remain unclear. We sought to investigate whether ameliorates inflammatory bowel disease (IBD) mice with dextran sulfate sodium (DSS)-induced ulcerative colitis (UC). Our results suggest that alleviates clinical symptoms DSS-induced...
Immunotherapies comprising programmed cell death protein 1/PD ligand 1 (PD-1/PD-L1) immune checkpoint inhibitors are effective cancer treatments. However, the low response rate and immunoresistance resulting from alternative upregulation inefficient stimulation by T cells problematic. The present report describes a biomimetic nanoplatform that simultaneously blocks T-cell immunoglobulin immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) activates stimulator of interferon genes...
Zebrafish-based chemical screening has recently emerged as a rapid and efficient method to identify important compounds that modulate specific biological processes test the therapeutic efficacy in disease models, including cancer. In leukemia, ablation of leukemia stem cells (LSCs) is necessary permanently eradicate cell population. However, because very small number LSCs populations, their use xenotransplantation studies (in vivo) difficulties functionally pathophysiologically replicating...
Competitive consumption of nutrients between rapidly proliferating cancer cells and T results in an immunosuppressive tumor microenvironment (TME) nutrient deprivation cells, which can cause low response rate resistance to immunotherapies. In this study, we proposed a dual-mechanism based partitioning nanoregulator (designated as DMNPN), simultaneously regulate the TME enhance cell availability. DMNPN consists charge-reversal biodegradable mesoporous silica, encapsulating glycolysis...
The precise building extraction from high-resolution remote sensing images holds significant application for urban planning, resource management, and environmental conservation. In recent years, deep neural networks (DNNs) have garnered substantial attention their adeptness in learning extracting features, becoming integral to methodologies yielding noteworthy performance outcomes. Nonetheless, prevailing DNN-based models often overlook spatial information during the feature phase....
Pharmaceutical safety testing requires a cheap, fast and highly efficient platform for real-time evaluation of drug toxicity secondary effects. In this study, we have developed microfluidic system phenotype-based toxic teratogenic effects drugs using zebrafish (Danio rerio) embryos larvae as the model organism. The chip is composed two independent functional units, enabling assessment larvae. Each unit consists fluidic concentration gradient generator row seven culture chambers to...
Glioblastoma (GBM) is the most lethal primary intracranial tumor because of its high invasiveness and recurrence. Therefore, nanocarriers with blood-brain barrier (BBB) penetration transcranial-controlled drug release activation are rather attractive options for glioblastoma treatment. Herein, we designed a multifunctional nanocarrier (T-TKNPVP) that combined targeted X-ray-induced photodynamic therapy (X-PDT) cascaded reactive oxygen species (ROS)-boosted chemotherapy. The T-TKNPVP loaded...
Background This study seeks to investigate the potential synergistic effects of combining ultrasound-guided percutaneous radiofrequency ablation with anti-PD-1 therapy on prostate cancer, utilizing animal models. Methods A mouse model cancer was established by subcutaneous injection 1 × 10 6 Myc-Cap cells right side FVB mice. When volume tumors reached about 400mm 3 , mice were randomly divided into four groups and received corresponding intervention treatments. Among them, Group blank...